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Development of tumor microenvironment responsive nanoparticles and investigation of the antitumor effect

Research Project

Project/Area Number 21790049
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Physical pharmacy
Research InstitutionKyoto Pharmaceutical University

Principal Investigator

HAMA Susumu  京都薬科大学, 薬学部, 助教 (60438041)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsがん微小環境 / ドラッグデリバリー
Research Abstract

Novel charge-invertible nanoparticles were developed that can respond to the acidic pH of a tumor. We designed a unique peptide(referred to as a slightly acidic pH sensitive peptide : SAPSP), as a pH responsive device for intelligent nanoparticles consisting of cationic liposomes. The cellular uptake of SAPSP-modified liposomes(SAPSP-lipo) increased at tumoral pH(pH 6. 5) due to conversion of the liposomal surface charge from negative to positive. In addition, siRNA-encapsulated SAPSP-lipo induced a significant knock down effect, but only at pH 6. 5. These results indicate that SAPSP-lipo represents a novel intelligent drug delivery system that can respond to tumoral pH for use in cancer therapy.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (31 results)

All 2012 2011 2010 2009 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (23 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Noninvasive and efficient transdermal delivery of CpG-oligodeoxynucleotide for cancer immunotherapy2011

    • Author(s)
      Kigasawa K, Kajimoto K, Nakamura T, Hama S, Kanamura K, Harashima H, Kogure K
    • Journal Title

      J. Control. Release

      Volume: 150 Pages: 256-265

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Noninvasive and efficient transdermal delivery of CpG-oligodeoxynucleotide for cancer immunotherapy2011

    • Author(s)
      Kigasawa K, Kajimoto K, Nakamura T, Hama S, Kanamura K, Harashima H, Kogure K
    • Journal Title

      J.Control.Release.

      Volume: 150 Pages: 256-265

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a Novel Drug Delivery System consisting of an Antitumor Agent Tocopheryl Succinate

    • Author(s)
      Hama S, Utsumi S, Fukuda Y, Nakayama K, Okamura Y, Tsuchiya H, Fukuzawa K, Harashima H, Kogure K
    • Journal Title

      J. Control. Release

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of Tumor Growth by Needle-free Jet Injection of anti-C7orf24 siRNA

    • Author(s)
      Hama S, Arata M, Nakamura I, Kasetani T, Itakura S, Tsuchiya S, Yoshiki T, Kogure K
    • Journal Title

      Cancer Gene Ther

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 細胞内動態に着目したトコフェロールコハク酸ナノ粒子の作用増強機構の解析2012

    • Author(s)
      濱進
    • Organizer
      第22回ビタミンE研究会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] ナノ粒子の膜物性制御による腫瘍低pH下の癌細胞への効率的な薬物送達2011

    • Author(s)
      濱進
    • Organizer
      第9回がんとハイポキシア研究会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 腫瘍の低いpHを利用した新規薬物キャリアーの開発2011

    • Author(s)
      中井麻友美
    • Organizer
      第27回日本DDS学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 核酸医薬を封入したトコフェロールコハク酸ナノ粒子の機能性評価2011

    • Author(s)
      濱進
    • Organizer
      日本ビタミン学会第63回大会
    • Place of Presentation
      広島
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 腫瘍環境応答性の表面物性を有するナノキャリアーの開発2011

    • Author(s)
      小暮健太朗
    • Organizer
      日本膜学会第33年会境界領域シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 抗癌活性を有するビタミンE誘導体を利用したナノ粒子の開発2011

    • Author(s)
      濱進
    • Organizer
      第17回国際癌治療増感研究会
    • Place of Presentation
      宮城
    • Related Report
      2011 Annual Research Report
  • [Presentation] Suppression of Tumor Grouth by Nanoparticles consisting of α-Tocopheryl Succinate2011

    • Author(s)
      濱進
    • Organizer
      The Third International Conference on Cofactors(ICC-03)
    • Place of Presentation
      Turku, Finland
    • Related Report
      2011 Annual Research Report
  • [Presentation] 抗癌活性を有するトコフェロールコハク酸を利用した遺伝子キャリアーの確立2011

    • Author(s)
      福田友紀
    • Organizer
      アンチセンス・遺伝子・デリバリーシンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腫瘍の低pH環境に応答して細胞親和性が向上する薬物キャリアーの開発2010

    • Author(s)
      濱進
    • Organizer
      遺伝子・デリバリー研究会第10回シンポジウム
    • Place of Presentation
      札幌
    • Related Report
      2011 Final Research Report
  • [Presentation] 腫瘍内低pHに応答する新しい薬物キャリアーの開発2010

    • Author(s)
      板倉祥子
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Related Report
      2011 Final Research Report
  • [Presentation] 膜物性制御したビタミンE誘導体ナノ粒子の抗腫瘍効果2010

    • Author(s)
      内海達
    • Organizer
      日本薬剤学会第25年会
    • Place of Presentation
      徳島
    • Related Report
      2010 Annual Research Report
  • [Presentation] 低酸素環境下の癌細胞に対する抗体の機能性評価2010

    • Author(s)
      濱進
    • Organizer
      日本薬剤学会第25年会
    • Place of Presentation
      徳島
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腫瘍の低pH環境に応答して細胞親和性が向上する薬物キャリアーの開発2010

    • Author(s)
      濱進
    • Organizer
      遺伝子・デリバリー研究会 第10回シンポジウム
    • Place of Presentation
      札幌
    • Related Report
      2010 Annual Research Report
  • [Presentation] 改良型トコフェロールコハク酸ナノ粒子の抗腫瘍効果2010

    • Author(s)
      内海達
    • Organizer
      日本ビタミン学会第62回大会
    • Place of Presentation
      盛岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] がん微小環境を利用した癌治療・診断法の開発2010

    • Author(s)
      濱進
    • Organizer
      ナノライフサイエンス・オープンセミナー2010
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] 低酸素環境下の癌細胞を認識する抗体の樹立と機能性評価2010

    • Author(s)
      濱進
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス黒色細胞腫に対するα-トコフェロールコハク酸ナノ粒子の抗腫瘍効果2010

    • Author(s)
      内海達
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腫瘍内低pHに応答する新しい薬物キャリアーの開発2010

    • Author(s)
      板倉祥子
    • Organizer
      日本薬学会 第130年会
    • Place of Presentation
      岡山
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低酸素環境下の癌認識抗体の機能性評価2010

    • Author(s)
      濱進
    • Organizer
      日本薬学会 第130年会
    • Place of Presentation
      岡山
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腫瘍環境に応答可能な新規薬物送達キャリアーの開発2009

    • Author(s)
      板倉祥子
    • Organizer
      遺伝子・デリバリー研究会第9回シンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] 腫瘍環境に応答して膜物性が変化するDDSナノ粒子2009

    • Author(s)
      板倉祥子
    • Organizer
      第59回 日本薬学会近畿支部総会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低酸素環境における癌特異的モノクローナル抗体の樹立2009

    • Author(s)
      首藤弘樹
    • Organizer
      第59回 日本薬学会近畿支部総会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腫瘍環境に応答可能な新規薬物送達キャリアーの開発2009

    • Author(s)
      板倉祥子
    • Organizer
      遺伝子・デリバリー研究会 9回シンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.kyoto-phu.ac.jp/labo/bukka/main.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.kyoto-phu.ac.jp/labo/bukka/main.html

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] pH応答性ペプチドを含むナノ粒子2012

    • Inventor(s)
      小暮健太朗、濱進
    • Industrial Property Rights Holder
      大鵬薬品工業株式会社
    • Filing Date
      2012-04-24
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] pH応答性ペプチドを含むナノ粒子2011

    • Inventor(s)
      小暮健太朗, 濱進
    • Industrial Property Rights Holder
      大鵬薬品工業株式会社
    • Industrial Property Number
      2011-097694
    • Filing Date
      2011-04-25
    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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