Investigation of change of serum glycoproteins with aging and its application to aging marker
| Project/Area Number |
21790050
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Kinki University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 分析化学 / 加齢マーカー / 糖タンパク質 / N-アセチルノイラミン酸 / メタボリックシンドローム |
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| Research Abstract |
Since structural alterations of glycans are known to be associated with changes of physiological environments, glycans have been received attention as target molecules for clinical biomarkers. In this study, we analyzed N- and O-glycans of glycoproteins from rat serum samples using capillary electrophoresis, and found that N-glycans showed disitinctive changes with age or high-fat diet. The present results indicate that glycans will be one of the useful biomarkers for aging.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Structural characterization of multibranched oligosaccharides from seal milk by a combination of off-line high-performance liquid chromatography-matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry and sequential exoglycosidase digestion.2009
Author(s)
Kinoshita M, Ohta H, Higaki K, Kojima Y, Urashima T, Nakajima K, Suzuki M, Kovacs KM, Lydersen C, Hayakawa T, Kakehi K.
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Journal Title
Anal Biochem. 388(2)
Pages: 242-253
Related Report
Peer Reviewed
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[Journal Article] Structural characterization of multibranched oligosaccharides from seal milk by a combination of off-line high-performance liquid chromatography-matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry and sequential exoglycosidase digestion2009
Author(s)
Kinoshita M, Ohta H, Higaki K, Kojima Y, Urashima T, Nakajima K, Suzuki M, Kovacs KM, Lydersen C, Hayakawa T, Kakehi K.
-
Journal Title
Anal Biochem. 388(2)
Pages: 242-253
Related Report
Peer Reviewed
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