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Regulatory mechanisms of presynaptic assembly by an adaptor protein SYD-2

Research Project

Project/Area Number 21790057
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionHokkaido University

Principal Investigator

TARU Hidenori  Hokkaido University, 創成研究機構, 特任助教 (30533731)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords神経生物学 / シナプス / SYD-2 / Liprin / 線虫
Research Abstract

Neuronal synapses are critical cell adhesion structures, which are specialized for intercellular signal transduction between neurons. To understand the molecular mechanisms of synaptic formation is one of the important challenges in neuroscience field and provides better understanding of higher brain function such as learning and memory and neurodegenerative diseases. An adapter protein SYD-2 is a key molecule for presynaptic assembly in nematode C.elegans. In this study, we showed that oligomerization is a critical step for the activation of SYD-2, and identified multiple modifier mutants, which may work together with SYD-2 for presynaptic assembly.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (11 results)

All 2010 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain2010

    • Author(s)
      Maho Kondo, Maki Shiono, Genzo Itoh, Norio Takei, Takahide Matsushima, Masahiro Maeda, Hidenori Taru, Saori Hata, Tohru Yamamoto, Yuhki Saito, Toshiharu Suzuki
    • Journal Title

      Molecular Neurodegeneration 5

      Pages: 35-35

    • NAID

      120005158908

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain2010

    • Author(s)
      Maho Kondo
    • Journal Title

      Molecular Neurodegeneration

      Volume: 5 Pages: 35-35

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Regulatory Interaction of SYD-1 in the specification of presynaptic sites in C.elegans2010

    • Author(s)
      多留偉功
    • Organizer
      第33回日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Regulatory Interaction of SYD-1 in the specification of presynaptic sites in C.elegans2010

    • Author(s)
      多留偉功
    • Organizer
      第33回 日本分子生物学会
    • Place of Presentation
      神戸 ポートアイランド
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Regulatory mechanism of SYD-2/Liprin-alpha activity in synapse formation2009

    • Author(s)
      多留偉功
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Regulatory mechanism of SYD-2/Liprin-alpha activity in synapse formation2009

    • Author(s)
      多留偉功
    • Organizer
      第32回 日本分子生物学会
    • Place of Presentation
      横浜、パシフィコ横浜
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経プレシナプス構造の部位決定機構の解析-線虫SYD-1とアダプター分子群の相互作用2009

    • Author(s)
      多留偉功
    • Organizer
      The 1st Conference on Intracellular Logistics
    • Place of Presentation
      沖縄ANAインターコンチネンタル万座
    • Year and Date
      2009-11-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 神経プレシナプス構造の部位決定機構の解析―線虫SYD-1とアダプター分子群の相互作用2009

    • Author(s)
      多留偉功
    • Organizer
      The 1^<st> Conference on Intracellular Logistics
    • Place of Presentation
      沖縄、ANAインターコンチネンタル万座
    • Year and Date
      2009-11-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経細胞のプレシナプス構造の再構成をめざして2009

    • Author(s)
      多留偉功
    • Organizer
      細胞を創る研究会2.0
    • Place of Presentation
      東京大学
    • Year and Date
      2009-10-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 神経細胞のプレシナプス構造の再構成をめざして2009

    • Author(s)
      多留偉功
    • Organizer
      細胞を創る研究会2.0
    • Place of Presentation
      東京、東京大学
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.cris.hokudai.ac.jp/taru/

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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