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Activation mechanism and functional analysis of insect cytokine PP on innate immune response

Research Project

Project/Area Number 21790063
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionThe University of Tokyo

Principal Investigator

HAMAMOTO Hiroshi  The University of Tokyo, 大学院・薬学系研究科, 助教 (90361609)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords自然免疫 / カイコ / 麻痺ペプチド / 昆虫サイトカイン / シグナル伝達 / 自然免疫応答 / サイトカイン / 細菌感染
Research Abstract

Insect cytokine PP (paralytic peptide) induce expression of genes for antimicrobial peptide via p38 MAPK pathway in fat body, and activate the phagocytic activity of hemocytes. Regarding the activation of PP, midgut has important role for recognition of cell wall components of bacteria and secret PP-activating factors. In this research, outline of function and activation mechanism of PP in innate immunity response was revealed.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (29 results)

All 2011 2010 2009 2008 Other

All Journal Article (10 results) (of which Peer Reviewed: 6 results) Presentation (14 results) Remarks (2 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] Purification of innate immunostimulant from green tea using a silkworm muscle contraction assay2011

    • Author(s)
      Dhital S, Hamamoto H, Urai M, Ishii K, Sekimizu K
    • Journal Title

      Drug Discoveries and Therapeutics 5

      Pages: 18-25

    • NAID

      130005054690

    • Related Report
      2010 Final Research Report
  • [Journal Article] Purification of innate immunostimulant from green tea using a silkworm muscle contraction assay2011

    • Author(s)
      Dhital S, Hamamoto H, Urai M, Ishii K, Sekimizu K
    • Journal Title

      Drug Discoveries and Therapeutics

      Volume: 5 Pages: 18-25

    • NAID

      130005054690

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Porphyromonas gingivalis peptidoglycans induce excessive activation of the innate immune system in silkworm larvae,2010

    • Author(s)
      Ishii K, Hamamoto H, Imamura K, Adachi T, Shoji M, Nakayama K, Sekimizu K
    • Journal Title

      J Biol Chem 285

      Pages: 33338-33347

    • Related Report
      2010 Final Research Report
  • [Journal Article] The insect cytokine paralytic peptide (PP) induces cellular and humoral immune responses in the silkworm Bombyx mori,2010

    • Author(s)
      Ishii K, Hamamoto H, Kamimura M, Nakamura Y, Noda H, Imamura K, Mita K, Sekimizu K
    • Journal Title

      J Biol Chem 285

      Pages: 28635-28642

    • Related Report
      2010 Final Research Report
  • [Journal Article] Porphyromonas gingivalis peptidoglycans induce excessive activation of the innate immune system in silkworm larvae.2010

    • Author(s)
      Ishii K, Hamamoto H, Imamura K, Adachi T, Shoji M, Nakayama K, Sekimizu K.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 285 Pages: 33338-33347

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insect cytokine paralytic peptide (PP) induces cellular and humoral immune responses in the silkworm Bombyx mori.2010

    • Author(s)
      Ishii K, Hamamoto H, Kamimura M, Nakamura Y, Noda H, Imamura K, Mita K, Sekimizu K.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 285 Pages: 28635-28642

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources.2010

    • Author(s)
      Asami Y, Horie R, Hamamoto H, Sekimizu K.
    • Journal Title

      BMC Pharmacology

      Volume: 10 Pages: 7-7

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources.2010

    • Author(s)
      Fujiyuki T, Imamura K, Hamamoto H, Sekimizu K
    • Journal Title

      Drug Discoveries and Therapeutics

      Volume: 4 Pages: 349-354

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Silkworm as a model animal to evaluate drug candidate toxicity and metabolism2009

    • Author(s)
      Hamamoto H, Tonoike A, Narushima K, Horie R, Sekimizu K.
    • Journal Title

      Comp Biochem Physiol C Toxicol Pharmacol 149

      Pages: 334-339

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hemocytes and humoral factors in silkworm blood are cooperatively involved in sheep erythrocyte aggregation

    • Author(s)
      Imamura K, Ishii K, Hamamoto H, Sekimizu K
    • Journal Title

      Drug Discoveries and Therapeutics inpress

    • NAID

      130005054704

    • Related Report
      2010 Final Research Report
  • [Presentation] カイコ細菌感染モデルを用いた治療効果を指標とした探索による、新規リポペプチド系抗生物質カイコシンの発見2011

    • Author(s)
      浜本洋、浦井誠、アトミカパウデル、堀江亮、村上和久、関水和久
    • Organizer
      日本薬学会第131年会(シンポジウム)
    • Place of Presentation
      静岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] カイコ幼虫体液に存在する細胞増殖抑制因子の精製と機能解析2010

    • Author(s)
      安達達朗
    • Organizer
      第9回次世代を担う若手ファーマバイオフォーラム
    • Place of Presentation
      名古屋
    • Year and Date
      2010-10-02
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] カイコ幼虫を用いた安全性試験・有効性試験2010

    • Author(s)
      浜本洋
    • Organizer
      日本実験代替法学会2010年講習会
    • Place of Presentation
      札幌
    • Year and Date
      2010-09-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] カイコと哺乳動物におけるシトクロームP450代謝反応の共通性2010

    • Author(s)
      堀江亮、浜本洋、関水和久
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター(岡山県)
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Insect cytokine paralytic peptide activates innate immunity via nitric oxide production in Bombyx mori2010

    • Author(s)
      Kenichi Ishii, Hiroshi Hamamoto, Manabu Kamimura, Kazuhisa Sekimizu
    • Organizer
      The 10th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      淡路
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] セラチア菌のO抗原によるカイコ血球細胞の細胞死誘導2010

    • Author(s)
      石井健一、臼井公人、今村亮俊、浜本洋、鈴木一史、渡邉剛志、関水和久
    • Organizer
      第32回日本分子生物学会・第83回日本生化学会大会合同年会(BMB2010)
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] Novel Therapeutically Effective Cyclic Lipopeptide Antibiotics Screened by Silkworm Infection Model2010

    • Author(s)
      H.HAMAMOTO, A.PAUDEL, M.URAI, R.HORIE, K.MURAKAMI, T.MOGI, K.SEKIMIZU
    • Organizer
      2010 Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Place of Presentation
      米国、ボストン
    • Related Report
      2010 Annual Research Report
  • [Presentation] カイコにおけるシトクロームP450に関する研究2010

    • Author(s)
      浜本洋、堀江亮、関水和久
    • Organizer
      第33回日本分子生物学会・第83回日本生化学会大会合同年会(BMB2010)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] セラチア菌のO抗原によるカイコ血球細胞の細胞死誘導2010

    • Author(s)
      石井健一、臼井公人、今村亮俊、浜本洋、鈴木一史、渡邉剛志、関水和久
    • Organizer
      第33回日本分子生物学会・第83回日本生化学会大会合同年会(BMB2010)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] カイコにおいて昆虫サイトカイン paralytic peptide により誘導される自然免疫応答2009

    • Author(s)
      石井健一、浜本洋、神村学、中村有希、野田博明、三田和英、関水和久
    • Organizer
      第32回分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-12-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Establishment of novel bioassay system for screening the anti-infectious compounds using silkworm infection model2009

    • Author(s)
      Hiroshi Hamamoto, Ryo Horie, Atmika Paudel, Kazuhisa Murakami, Kazuhisa Sekimizu
    • Organizer
      第31回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      大阪大学(大阪府)
    • Year and Date
      2009-11-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] カイコにおけるシトクロームP450代謝反応に関する研究2009

    • Author(s)
      堀江亮、浜本洋、関水和久
    • Organizer
      第82回日本生化学会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Metabolic reaction in silkworm by cytochrome P4502009

    • Author(s)
      堀江亮、浜本洋、関水和久
    • Organizer
      16th International Conference on Cytochrome P450
    • Place of Presentation
      万国津梁館(沖縄県)
    • Year and Date
      2009-06-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] カイコにおいて昆虫サイトカインparalytic peptideにより誘導される自然免疫応答2009

    • Author(s)
      石井健一、浜本洋、神村学、中村有希、野田博明、三田和英、関水和久
    • Organizer
      第32回分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.f.u-tokyo.ac.jp/~bisei/research_hamamoto.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.f.u-tokyo.ac.jp/~bisei/research_hamamoto.html

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 植物体由来の自然免疫活性化作用が増強された自然免疫活性化組成物2009

    • Inventor(s)
      関水和久、浜本洋、小方康至
    • Industrial Property Rights Holder
      関水和久、浜本洋、小方康至
    • Filing Date
      2009-06-22
    • Related Report
      2010 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 自然免疫機構を活性化/抑制する作用を有する物質の評価方法及びスクリーニング方法、並びに、自然免疫機構を活性化/抑制するための薬剤、食品及びそれらの製造方法2008

    • Inventor(s)
      関水和久、浜本洋
    • Industrial Property Rights Holder
      関水和久、浜本洋
    • Industrial Property Number
      2009-509376
    • Filing Date
      2008-04-10
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 自然免疫機能活性化組成物の製造方法及び自然免疫機能活性化組成物2008

    • Inventor(s)
      関水和久、浜本洋
    • Industrial Property Rights Holder
      関水和久、浜本洋
    • Industrial Property Number
      2009-148108
    • Filing Date
      2008-07-02
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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