Molecular mechanism of apoptotic pathway through the tumor suppressor protein p53 approached from gene expression control
Project/Area Number |
21790066
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Biological pharmacy
|
Research Institution | University of Toyama |
Principal Investigator |
TANAKA Aki University of Toyama, 医学薬学研究部(薬学), 助教 (50432109)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 転写 / 基本転写因子 / TFIIE / TFIIH / 癌抑制遺伝子産物p53 / 免疫沈降実験 / 癌抑制遺伝子産物 p53 |
Research Abstract |
The general transcription factors TFIIE and TFIIH play essential roles in transcription initiation by RNA polymerase II. The possibility is shown that the phosphorylation modification of tumor suppressor protein p53 at serin 46 and threonine 55 influence the interaction of two factors. It is shown that p53 received DNA damage by ultraviolet and anti-cancer drug stabilized in the cell, the interaction with TFIIH is given to priority more than interactive with TFIIE by the post-translational modification of p53.
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Report
(3 results)
Research Products
(16 results)