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Signal transductions of R-Ras family GTPases

Research Project

Project/Area Number 21790069
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionKyoto University

Principal Investigator

OINUMA Izumi  Kyoto University, 大学院・生命科学研究科, 助教 (40452297)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywordsシグナル伝達 / 神経科学 / R-Ras / H-Ras / TC21 / neuron / axon / dendrite / Myosin / integrin / 細胞接着
Research Abstract

We have identified roles of R-Ras family of small GTPases, which functions downstream of the repulsive axon guidance molecule, semaphorin and its receptor, Plexin.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report

Research Products

(13 results)

All 2010 2009 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (4 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Semaphorin 4D/plexin-B1 stimulates PTEN activity through R-Ras GTPase-activating protein activity, inducing growth cone collapse in hippocampal neurons.2010

    • Author(s)
      Izumi Oinuma, Yuri Ito, Hironori Katoh, Manabu Negishi
    • Journal Title

      J.Biol.Chem. 285

      Pages: 28200-28209

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Semaphorin 4D/plexin-B1 stimulates PTEN activity through R-Ras GTPase-activating protein activity, inducing growth cone collapse in hippocampal neurons2010

    • Author(s)
      Izumi Oinuma, Yuri Ito, Hironori Katoh, Manabu Negishi
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 28200-28209

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plexin-B1 is a GTPase activating protein for M-Ras, remodelling dendrite morphology.2009

    • Author(s)
      Yasuhiro Saito, Izumi Oinuma, Satoshi Fujimoto, Manabu Negishi.
    • Journal Title

      EMBO Rep 10

      Pages: 614-621

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plexin-B1 is a GTPase activating protein for M-Ras, remodeling dendrite morphology.2009

    • Author(s)
      Yasuhiro Saito, Izumi Oinuma, Hironori Katoh, Manabu Negishi
    • Journal Title

      EMBO reports 10

      Pages: 614-621

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] M-Rasの新奇エフェクターであるLamellipodinはアクチン骨格系の制御により樹状突起伸長を制御するLamellipodin, a novel effector of M-Ras, regulates the dendritic maturation through reconstructing actin network2010

    • Author(s)
      田坂元一、生沼泉、根岸学
    • Organizer
      BMB2010
    • Place of Presentation
      神戸国際会議場(招待講演)
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular mechanism of integrin activation by R-Ras2009

    • Author(s)
      生沼泉、根岸学
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-10-23
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 神経回路形成へのナビゲーション2009

    • Author(s)
      生沼泉
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2009-10-22
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] M-Rasの新奇エフェクターであるLamellipodinはアクチン骨格系の制御により樹状突起伸長を制御する

    • Author(s)
      田坂元一、生沼泉、根岸学
    • Organizer
      Lamellipodin, a novel effector of M-Ras, regulates the dendritic maturation through reconstructing actin network
    • Related Report
      2010 Final Research Report
  • [Book] ブレインサイエンスレビュー2010

    • Author(s)
      伊藤正男、川合述史、水島昇、生沼泉、大島登志男、太田訓正、船越洋、柳川右千男、森吉弘毅、佐藤純、浜千尋、長谷川功、鎌田恭輔、三澤日出巳
    • Total Pages
      263
    • Publisher
      クバプロ出版
    • Related Report
      2010 Final Research Report
  • [Book] ブレインサイエンスレビュー20102010

    • Author(s)
      伊藤正男、川合述史、水島昇、生沼泉、大島登志男、太田訓正、船越洋、柳川右千男、森吉弘毅、佐藤純、浜千尋、長谷川功、鎌田恭輔、三澤日出巳
    • Publisher
      クバプロ
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ等研究成果は以下のホームページに掲載している。

    • URL

      http://www.users.kudpc.kyoto-u.ac.jp/~p51907/negishi/index.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.users.kudpc.kyoto-u.ac.jp/~p51907/negishi/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.users.kudpc.kyoto-u.ac.jp/~p51907/negishi/index.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-03-31   Modified: 2016-04-21  

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