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Investigation of a novel mechanism of cholinergic activation for cognitive impairment treatment

Research Project

Project/Area Number 21790091
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionKeio University

Principal Investigator

OKUDA Takashi  Keio University, 薬学部, 講師 (00322040)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords認知症 / コリン作動性神経 / アセチルコリン / コリントランスポーター / トラフィッキング / 高親和性コリントランスポーター / 細胞内移行 / アセチルコリン合成
Research Abstract

Cholinergic neurons are involved in cognitive function in the central nervous system. At the cholinergic presynaptic terminals, acetylcholine synthesis relies on the high-affinity choline transporter (CHT1) for efficient choline supply from extracellular fluid. The choline uptake is the rate-limiting step in acetylcholine synthesis. We find that extracellular substrate regulates the cell surface CHT1 by enhancing its internalization rate. We also find that tetrahydropyrimidines are competitive inhibitors of CHT1.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (12 results)

All 2011 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (6 results)

  • [Journal Article] Acetylcholine synthesis and release in NIH3T3 cells coexpressing the high-affinity choline transporter and choline acetyltransferase.2009

    • Author(s)
      Fujii, T., Masai, M., Misawa, H., Okuda, T., Takada-Takatori, Y., Moriwaki, Y., Haga, T., Kawashima, K.
    • Journal Title

      J.Neurosci.Res. 87

      Pages: 3024-3032

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Primary sensory neuronal expression of SLURP-1, an endogenous nicotinic acetylcholine receptor ligand.2009

    • Author(s)
      Moriwaki, Y., Watanabe, Y., Shinagawa, T., Kai, M., Miyazawa, M., Okuda, T., Kawashima, K., Yabashi, A., Waguri, S., Misawa, H.
    • Journal Title

      Neurosci.Res. 64

      Pages: 403-412

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of SLURP-1, an endogenous alpha7 nicotinic acetylcholine receptor allosteric ligand, in murine bronchial epithelial cells.2009

    • Author(s)
      Horiguchi, K., Horiguchi, S., Yamashita, N., Irie, K., Masuda, J., Takano-Ohmuro, H., Himi, T., Miyazawa, M., Moriwaki, Y., Okuda, T., Misawa, H., Ozak,i H., Kawashima, K.
    • Journal Title

      J.Neurosci.Res. 87

      Pages: 2740-2747

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of SLURP-1, an endogenous alpha7 nicotinic acetylcholine receptor allosteric ligand, in murine bronchial epithelial cells.2009

    • Author(s)
      Horiguchi, K., et al.
    • Journal Title

      J.Neurosci.Res. 87

      Pages: 2740-2747

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Primary sensory neuronal expression of SLURP-1, an endogenous nicotinic acetylcholine receptor ligand.2009

    • Author(s)
      Moriwaki, Y., et al.
    • Journal Title

      Neurosci.Res. 64

      Pages: 403-412

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acetylcholine synthesis and release in NIH3T3 cells expressing the high-affinity choline transporter and choline acetyltransferase.2009

    • Author(s)
      Fujii, T., et al.
    • Journal Title

      J.Neurosci.Res. 87

      Pages: 3024-3032

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] シナプス小胞トランスポーターの細胞内移行シグナル配列の探索2011

    • Author(s)
      神保美紗子、三澤日出巳、奥田隆志
    • Organizer
      第124回日本薬理学会関東部会
    • Place of Presentation
      東京大学
    • Year and Date
      2011-06-04
    • Related Report
      2010 Final Research Report
  • [Presentation] シナプス小胞トランスポーターの細胞内移行モチーフの探索2011

    • Author(s)
      神保美紗子、三澤日出巳、奥田隆志
    • Organizer
      第84回日本薬理学会年会(震災により中止)
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-03-23
    • Related Report
      2010 Final Research Report
  • [Presentation] シナプス小胞トランスポーターの細胞内移行モチーフの探索2011

    • Author(s)
      神保美紗子、三澤日出巳、奥田隆志
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(中止)
    • Year and Date
      2011-03-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] テトラヒドロピリミジン系薬の新たな中枢神経作用点の同定2010

    • Author(s)
      小西麻未、野村有希、奥田隆志、三澤日出巳
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-03-18
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] SLC5トランスポーターのオリゴマー形成におけるグリシンモチーフの役割2010

    • Author(s)
      矢嶋浩平、中田光、奥田隆志、三澤日出巳
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-03-18
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] テトラヒドロピリミジン系薬の新たな中枢神経作用点の同定2009

    • Author(s)
      野村有希、小西麻未、奥田隆志、三澤日出巳
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2009
    • Place of Presentation
      慶應義塾大学
    • Year and Date
      2009-08-24
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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