The role of uPAR on the LPS-induced bone resorption.
Project/Area Number |
21790097
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Biological pharmacy
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Research Institution | Doshisha Women's College of Liberal Arts |
Principal Investigator |
KANNO Yosuke Doshisha Women's College of Liberal Arts, 薬学部, 助教 (40416178)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | LPS / uPAR / 炎症性骨破壊 / 破骨細胞 |
Research Abstract |
We found that the absent of uPAR attenuated LPS-induced osteoclast differentiation and bone destruction. In addition, we found that uPAR regulated LPS-induced osteoclast differentiation through NF-kB pathway. Moreover, The inhibitor of integrin pathway attenuated uPAR-increased osteoclasts differentiation. These data suggest that uPAR plays a pivotal role on the LPS-induced osteoclasts differentiation.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Plasminogen/Plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function.2011
Author(s)
Yosuke Kanno, Akira Ishisaki, Eri Kawashita, Naoyuki Chosa, Keiichi Nakajima, Tatsuji Nishihara, Kuniaki Toyoshima, Kiyotaka Okada, Shigeru Ueshima, Kenji Matsushita, Osamu Matsuo, Hiroyuki Matsuno
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Journal Title
J Biol Chem. 286
Pages: 8952-8960
Related Report
Peer Reviewed
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