Immune modulatory functions of mature mast cells

• Project/Area Number: 21790100
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Okayama University
• Principal Investigator: TANAKA Satoshi Okayama University, 大学院・医歯薬学総合研究科, 准教授 (40303846)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: マスト細胞 / 線維芽細胞 / 細胞分化 / 脱顆粒 / アレルギー / 抗原抗体反応 / サイトカイン / 皮膚 / Gi / compound 48 / 80

Research Abstract

Mast cells are a kind of immune cells, which are widely distributed throughout the body, and are different in character depending on where they are resident. The functional roles of mature mast cells were investigated in this study using a novel culture model for mature mast cells. Mature mast cells were found to acquire the ability to respond to non-IgE stimuli, whereas they exhibited lower responses to IgE-dependent antigen stimulation. These findings suggest that appropriate culture models for tissue mature mast cells should be required for clarification of their immune modulatory functions.

Research Products

• [Journal Article] マスト細胞研究の新たな展開 (2011)
  • Author(s): 田中智之、西田圭吾
  • Journal Title: 薬学雑誌 131 Pages: 59-61
  • NAID: 130000451527
• [Journal Article] 皮膚型マスト細胞モデルの確立とその解析 (2011)
  • Author(s): 田中智之
  • Journal Title: 薬学雑誌 131 Pages: 63-71
  • NAID: 130000451528
• [Journal Article] Crucial role for autophagy in degranulation of mast cells. J. Allergy Clin. (2011)
  • Author(s): Ushio, H., Ueno, T., Kojima, Y., Komatsu, M., Tanaka, S., Yamamoto, A., Ichimura, Y., Ezaki, J., Nishida, K., Komazawa-Sakon, S., Niyonsaba, F., Ishi, T., Yanagawa, T., Kominami, E., Ogawa, H., Okumura, K., Nakano, H.
  • Journal Title: Immunol. in press
• [Journal Article] Crucial role for autophagy in degranulation of mast cells. (2011)
  • Author(s): Ushio, H., Ueno, T., Kojima, Y., Komaou, M., Tanaka, S., Yamamoto, A., Ichimura, Y., Eraki, J., Nishida, K., Komarawa-Sakon, S., Niyouaba, F., Ishi, T., Yanagawa, T., Komoami, E., Ogawa, H., Okamara, K., Nakano, H.
  • Journal Title: J.Allergy Clin.Immunol. Volume: (in press)
  • Peer Reviewed
• [Journal Article] マスト細胞研究の新たな展開 (2011)
  • Author(s): 田中智之、西田圭吾
  • Journal Title: 薬学雑誌 Volume: 131 Pages: 59-61
  • NAID: 130000451527
  • Peer Reviewed
• [Journal Article] 皮膚型マスト細胞モデルの確立とその解析 (2011)
  • Author(s): 田中智之
  • Journal Title: 薬学雑誌 Volume: 131 Pages: 63-71
  • NAID: 130000451528
  • Peer Reviewed
• [Journal Article] Impaired activation of mast cells upon IgE-mediated antigen stimulation in a stroke-prone spontaneously hypertensive rat strain, SHRSP.Z. (2010)
  • Author(s): Sakanaka, M., Furuta, K., Ichikawa, A., Tanaka, S.
  • Journal Title: Immunol. Lett. 128 Pages: 74-79
• [Journal Article] Suppression of CXCR4 expression in mast cells upon IgE-mediated antigen stimulation. (2010)
  • Author(s): Matsuura, J., Sakanaka, M., Sato, N., Ichikawa, A., Tanaka, S.
  • Journal Title: Inflamm. Res. 59 Pages: 123-127
• [Journal Article] Enhancement of IgM production in B cells by the extract of red bell pepper. (2010)
  • Author(s): Goto, T., Sarker, M.M.R., Zhong, M., Tanaka, S., Gohda, E.
  • Journal Title: J.Health Sci. 56 Pages: 304-309
• [Journal Article] Targeting CD44 in mast cell regulation. (2010)
  • Author(s): Tanaka, S.
  • Journal Title: Expert Opin Ther Targets 14 Pages: 31-43
• [Journal Article] Molecular biology of histidine decarboxylase and prostaglandin receptor. (2010)
  • Author(s): Ichikawa, A., Sugimoto, Y., Tanaka, S.
  • Journal Title: Proc. Jpn. Acad. Ser. B. 86 Pages: 848-866
  • NAID: 130000442356
• [Journal Article] マスト細胞の分化に伴う機能制御 (2010)
  • Author(s): 田中智之
  • Journal Title: 生化学 82 Pages: 1021-1031
  • NAID: 10027708617
• [Journal Article] Enhancement of IgM production in B cells by the extract of red bell pepper. (2010)
  • Author(s): Goto, T., Sarker, M.M.R., Zhong, M., Tanaka, S., Gohda, E.
  • Journal Title: J.Health Sci. Volume: 56 Pages: 304-309
  • Peer Reviewed
• [Journal Article] Molecular Biology of Histidine Decarboxylase and Prostaglandin Receptors. (2010)
  • Author(s): Ichikawa, A, Sugimoto, Y., Tanaka S.
  • Journal Title: Proc.Jpn.Acad.Ser.B Volume: 86 Pages: 848-866
  • NAID: 130000442356
  • Peer Reviewed
• [Journal Article] Targeting CD44 in mast cell regulation. (2010)
  • Author(s): Tanaka, S.
  • Journal Title: Expert Opin.Ther.Targets Volume: 14 Pages: 31-43
  • Peer Reviewed
• [Journal Article] マスト細胞の分化に伴う機能制御 (2010)
  • Author(s): 田中智之
  • Journal Title: 生化学 Volume: 82 Pages: 1021-1031
  • NAID: 10027708617
  • Peer Reviewed
• [Journal Article] Impaired activation of mast cells upon IgE-mediated antigen stimulation in a stroke-prone spontaneously hypertensive rat strain, SHRSPZ. (2010)
  • Author(s): Sakanaka, M., Funuta, K., Ichikaxa, A., Tanaka S.
  • Journal Title: Immunol.Lett. 128 Pages: 74-79
  • Peer Reviewed
• [Journal Article] Suppression of CXCR4 expression in mast cells upon IgE-mediated antigen stimulation. (2010)
  • Author(s): Matsuura, J., Sakanaka. M., Sato. N., Ichikawa. A., Tanaka, S.
  • Journal Title: Inflamm.Res. 59 Pages: 123-127
  • Peer Reviewed
• [Journal Article] Interleukin-4-mediated suppression of histamine synthesis in a murine mast cell line, BNu-2c13. (2009)
  • Author(s): Sato, N., Tanaka, S., Matsuura, J., Takasu, Y., Ichikawa, A.
  • Journal Title: Biol. Pharm. Bull. 32 Pages: 1800-1802
• [Journal Article] Prostaglandin EP3 receptor superactivates adenylyl cyclase via the Gq/PLC/Ca^<2+> pathway in a lipid raft-dependent manner. (2009)
  • Author(s): Yamaoka, K., Yano, A., Kuroiwa, K., Morimoto, K., Inazumi, T., Hatae, N., Tabata, H., Segi-Nishida, E., Tanaka, S., Ichikawa, A., Sugimoto, Y.
  • Journal Title: Biochem. Biophys. Res. Commun. 389 Pages: 678-682
• [Journal Article] Interleukin-4-mediated suppression of histamine synthesis in a murine mast cell line, BNu-2c13. (2009)
  • Author(s): Sato.N., Tanaka.S., Matsuum, J., Takasu, Y., Ichikoua.A.
  • Journal Title: Biol.Pharm.Bull. 32 Pages: 1800-1802
  • Peer Reviewed
• [Journal Article] Prostaglandin EP3 receptor superactivates adenylyl cyclase via the Gq/PLC/Ca2+ pathway in a lipid raft-dependent manner. (2009)
  • Author(s): Yamaoka, K., Yano, A., Kuroiwa, K., Morimoto, K., Inazumi, T., Hatae, N.,Tabata, Segi-Nishida, E., Tanaka, S Ichikawa A, Sugimoto Y
  • Journal Title: Biochem.Biophys.Res.Commun. 389 Pages: 678-682
  • Peer Reviewed
• [Presentation] 抗原刺激による脱顆粒レベルのIgEによる制御 (2010)
  • Author(s): 田中智之、栗宗由樹、阪中麻利子、夏原麻由子
  • Organizer: 第83回日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] 抗原刺激による脱顆粒レベルのIgEによる制御 (2010)
  • Author(s): 田中智之、栗宗由樹、阪中麻利子、夏原麻由子
  • Organizer: 第83回日本生化学会
  • Place of Presentation: 神戸市
  • Year and Date: 2010-12-10
• [Presentation] Establishment of a model culture system for cutaneous mast cells. (2010)
  • Author(s): Tanaka, S.
  • Organizer: 2010 XIII PHR(第13回ポーランドヒスタミン研究会)
  • Place of Presentation: ポーランド
  • Year and Date: 2010-10-23
• [Presentation] Establishment of a model culture system for cutaneous mast cells (2010)
  • Author(s): Tanaka, S.
  • Organizer: 2010 XIII PHRS(第13回ポーランドヒスタミン研究会)
  • Place of Presentation: ウッチ(ポーランド)
  • Year and Date: 2010-10-23
• [Presentation] CD44-mediated proliferation of mast cells. (2010)
  • Author(s): Tanaka, S.
  • Organizer: Hyaluronan 2010(第8回国際ヒアルロン酸学会)
  • Place of Presentation: 京都
  • Year and Date: 2010-06-06
• [Presentation] CD44-mediated proliferation of mast cells (2010)
  • Author(s): Tanaka, S.
  • Organizer: Hyaluronan 2010(第8回国際ヒアルロン酸学会)
  • Place of Presentation: 京都市
  • Year and Date: 2010-06-06
• [Presentation] マスト細胞の分化過程におけるCD44を介した増殖応答 (2010)
  • Author(s): 田中智之、合田榮一
  • Organizer: 日本組織培養学会第83回大会
  • Place of Presentation: 岡山
  • Year and Date: 2010-05-20
• [Presentation] マスト細胞の分化過程におけるCD44を介した増殖応答 (2010)
  • Author(s): 田中智之、合田榮一
  • Organizer: 日本組織培養学会第83回大会
  • Place of Presentation: 岡山市
  • Year and Date: 2010-05-20
• [Presentation] 皮膚型マスト細胞モデルの確立とその解析(シンポジウム「マスト細胞研究の新たな展開」) (2010)
  • Author(s): 田中智之
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-28
• [Presentation] CD44を介したマウス組織結合型マスト細胞の増殖制御 (2009)
  • Author(s): 田中智之、高野裕嗣、木全弘治、中山和久、杉本幸彦、市川厚
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] CD44を介したマウス組織結合型マスト細胞の増殖制御 (2009)
  • Author(s): ○田中智之、高野裕嗣、木全弘治、中山和久、杉本幸彦、市川厚
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸市
  • Year and Date: 2009-10-23
• [Presentation] マスト細胞の機能制御に関わる分子機構の解析(日本生化学会奨励賞受賞講演) (2009)
  • Author(s): 田中智之
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-21
• [Presentation] マスト細胞の機能制御に関わる分子機構の解析(奨励賞受賞講演) (2009)
  • Author(s): ○田中智之
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸市
  • Year and Date: 2009-10-21
• [Presentation] 高血圧モデルラットマスト細胞における抗原抗体反応の減弱機構 (2009)
  • Author(s): 田中智之、阪中麻利子、古田和幸、市川厚
  • Organizer: 第13回日本ヒスタミン学会
  • Place of Presentation: 仙台
  • Year and Date: 2009-10-08
• [Presentation] 高血圧モデルラットマスト細胞における抗原抗体反応の減弱機構 (2009)
  • Author(s): ○田中智之、阪中麻利子、古田和幸、市川厚
  • Organizer: 第13回日本ヒスタミン学会
  • Place of Presentation: 仙台市
  • Year and Date: 2009-10-08
• [Book] Biomedical Aspects of Histamine : Current Perspectives (ed. Khardori, N., Shahid, M., Khan, RA, Tripathi, T) Springer (2010)
  • Author(s): Tanaka, S., Ichikawa, A.
  • Total Pages: 350
  • Publisher: Chapter 2
• [Book] Biomedical Aspects of Histamine : Current Perspectives (ed.Khardori, N., Shahid, M., Khan, RA, and Tripathi, T) (2010)
  • Author(s): Tanaka, S., Ichikawa, A, et al.
  • Total Pages: 350
  • Publisher: Springer
• [Remarks] ホームページ等
  • URL: http://www.cc.okayama-u.ac.jp/~tanaka-s/
• [Remarks]
  • URL: http://www.cc.okayama-u.ac.jp/~tanaka-s/
• [Remarks]
  • URL: http://www.cc.okayama-u.ac.jp/~tanaka-s/