• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Synthesis and structure activity relationship of atpenin A5 derivatives as complex II inhibitors

Research Project

Project/Area Number 21790117
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Drug development chemistry
Research InstitutionKitasato University

Principal Investigator

OHTAWA Masaki  Kitasato University, 薬学部, 助教 (70453503)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords天然有機化合物 / 生理活性物質 / 構造活性相関 / 創薬化学 / 天然物
Research Abstract

Comprehensive structure activity relationship of atpenin A5 as a potent complex II inhibitor and the synthesis of atpenin A5/flutolanil chimeric inhibitors has been achieved. On the guidance of this study, we also constructed a potential basis for the discovery of atpenin A5 derivatives as novel antihelminth agents.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (6 results)

All 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] Enantioselective total synthesis of atpenin A5.2009

    • Author(s)
      Ohtawa, M.; Ogihara, S.; Sugiyama, K.; Shiomi, K.; Harigaya, Y.; Nagamitsu, T.; Omura, S.
    • Journal Title

      J. Antibiot. 62

      Pages: 289-294

    • NAID

      10030635353

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enantioselective total synthesis of atpenin A52009

    • Author(s)
      Ohtawa, M., et. al.
    • Journal Title

      The Journal of Antibiotics 62

      Pages: 289-294

    • NAID

      10030635353

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] NFRD阻害剤atpenin類の全合成ならびに構造活性相関研究2010

    • Author(s)
      杉山晃平(大多和正樹)
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      桃太郎アリーナ(岡山)
    • Related Report
      2010 Final Research Report
  • [Presentation] Enantioselective total synthesls of atpenins2009

    • Author(s)
      Ohtawa, M., et. al.
    • Organizer
      The 11^<th> International Kyoto Conference on New Aspects of Organic Chemistry
    • Place of Presentation
      京都リーガロイヤルホテル(京都府)
    • Year and Date
      2009-11-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Fumarate reductase阻害剤atpenin類の全合成ならびに構造活性相関研究2009

    • Author(s)
      杉山晃平(大多和正樹)
    • Organizer
      第28回メディシナルケミストリーシンポジウム
    • Place of Presentation
      東京大学安田講堂(東京)
    • Related Report
      2010 Final Research Report
  • [Presentation] Enantioselective total synthesis of atpenin A5 and its analogues.2009

    • Author(s)
      杉山晃平(大多和正樹)
    • Organizer
      The 11^<th> International KYOTO conerence on New Aspects of Organic Chemistry.
    • Place of Presentation
      リーガロイヤルホテル京都(京都)
    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi