• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of Host Nanoparticle - Guest PET Tracer System for Supersensitive Molecular Imaging and Drug Discovery

Research Project

Project/Area Number 21790125
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Drug development chemistry
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

ZHANG Zhouen  The Institute of Physical and Chemical Research, 分子イメージング創薬化学研究チーム, 研究員 (00416207)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsホスト・ナノ粒子-ゲストPETプローブシステム / 超高感度イメージング / ドラックデリバリー(DDS) / がん / PET / PETイメージング / ドラッグデリバリー / 医薬品化学
Research Abstract

In order to enhance the sensitivity and reliability of PET imaging, we proposed a novel strategy of amplifying tumor molecular marker, and attempted to develop multifunctional "tumor-targeting host nanoparticle-guest PET tracer system". PAMAM dendrimer - cyclodextrin (PAMAM-CD) as host nanoparticle, and several C-11 labeled carborane derivatives as guest PET tracers was designed and prepared. Such kind of host nanoparticle-guest PET tracer system could be applied to the supersensitive imaging for cancer diagnosis and imaging-guided therapy.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (5 results)

All 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Highly efficient syntheses of [methyl-11C] thymidine and its analogue 4'-[methyl-^<11>C] thiothymidine as nucleoside PET probes for cancer cell proliferation by Pd0- mediated rapid C-[^<11>C] methylation.2011

    • Author(s)
      Koyama H., Zhang Z., Suzuki M., et al.
    • Journal Title

      Organic & Biomolecular Chemistry 9

      Pages: 4287-4294

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] Efficient syntheses of [methyl-^<11>C] thymidine and its stable analogue 4'-[methyl-^<11>C] thiothymidine based on the Pd^0-mediated rapid C-[^<11>C]methylations.2010

    • Author(s)
      Koyama H., Zhang Z., Suzuki M., et al
    • Organizer
      Pacifichem 2010 Congress
    • Place of Presentation
      Honolulu, Hawaii.
    • Year and Date
      2010-12-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Efficient syntheses of [methyl-^<11>C] thymidine and its stable analogue 4'-[methyl-^<11>C] thiothymidine based on the Pd^0-mediated rapid C-[11C] methylations2010

    • Author(s)
      H.Koyama, Z.Zhang, M.Suzuki, et al
    • Organizer
      Pacifichem 2010 Congress
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2010-12-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] High-yield practical synthesis of [methyl-^<11>^C] thymidine and its stable analogue 4'-[methyl-^<11>C] thiothymidine by Pd^0-mediated rapid C-[^<11>C] methylation.2010

    • Author(s)
      Koyama H., Zhang Z., Suzuki M., et al
    • Organizer
      2010 world Molecular Imaging Congress.
    • Place of Presentation
      Kyoto.
    • Year and Date
      2010-09-09
    • Related Report
      2010 Final Research Report
  • [Presentation] High-yield practical synthesis of [methyl-^<11>C] thymidine and its stable analogue 4'-[methyl-^<11>C] thiothymidine by Pd^0-mediated rapid C-[11C] methylation2010

    • Author(s)
      H.Koyama, Z.Zhang, M.Suzuki, et al
    • Organizer
      2010 World Molecular Imaging Congress
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-09-09
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi