Essential role of HIF-1alpha in Mycobacterium tuberculosis-infected macrophage
Project/Area Number |
21790130
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Environmental pharmacy
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Research Institution | Osaka City University |
Principal Investigator |
OKA Mayuko Osaka City University, 大学院・医学研究科, 研究員 (40347498)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 低酸素 / 結核 / HIF-1alpha / マクロファージ / 肉芽腫 / HIF-lalpha |
Research Abstract |
Hypoxia-inducible factor-1α (HIF-1α) protein expressed in mouse pulmonary granulomas 6 weeks after infected with Mycobacterium tuberculosis, and the expression colocalized with that of M. tuberculosis antigen. Thus we focused to a role of HIF-1α into macrophages accumulated in granulomas. Our resulted investigated that the survival of M. tuberculosis in bone marrow derived macrophages (BMDM) from HIF-1α deficient mouse (HIF-1α^<-/->) is enhanced, compared with that in wild type BMDM (WT), which are post-stimulated with interferon-γ (IFN-γ) after infected with M. tuberculosis H37Rv. When infected with bacillus, the mRNA levels of 6 kinds of glycolytic enzymes were elevated in WT compared with HIF-1α^<-/->. In this study, we suggested that an increase of bacillus is controlled by HIF-1α.
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Report
(3 results)
Research Products
(32 results)
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[Journal Article] Transient role of CD4+CD25+ regulatory T cells in mycobacterial infection in mice.2010
Author(s)
Ozeki Y, Sugawara I, Udagawa T, Aoki T, Osada-Oka M, Tateishi Y, Hisaeda H, Nishiuchi Y, Harada N, Kobayashi K, Matsumoto S.
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Journal Title
Int.Immunol. 22(3)
Pages: 179-189
Related Report
Peer Reviewed
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[Journal Article] Transient role of CD4+CD25+ regulatory T cells in mycobacterial infection in mice2010
Author(s)
Ozeki Y, Sugawara I, Udagawa T, Aoki T, Osada-Oka M, Tateishi Y, Hisaeda H, Nishiuchi Y, Harada N, Kobayashi K, Matsumoto S.
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Journal Title
Int.Immunol.
Volume: 22
Pages: 179-189
Related Report
Peer Reviewed
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[Journal Article] Transient role of CD4+CD25+ regulatory T cells in mycobacterial infection in mice.2010
Author(s)
Ozeki, Y., Sugawara, I., Udagawa, T., Aoki, T., Osada-Oka M., Tateishi, Y., Hisaeda, H., Nishiuchi, Y., Harada, N., Kobayashi, K., Matsumoto, S.
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Journal Title
Int Immunol 22
Pages: 179-189
Related Report
Peer Reviewed
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[Journal Article] S-allylcysteine is effective as a chemopreventive agent against porcine serum-induced hepatic fibrosis in rats.2009
Author(s)
Shinkawa, H., Takemura, S., Minamiyama, Y., Kodai, S., Tsukioka, T., Osada-Oka, M., Kubo, S., Okada, S., Suehiro, S.
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Journal Title
Osaka City Med J 55
Pages: 61-69
Related Report
Peer Reviewed
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[Presentation] Transient role of CD4^+CD25^+ regulatory T cells in mycobacterial infection in mice2010
Author(s)
Ozaki Y, Sugawara I, Udagawa T, Aoki T, Osada-Oka M, Tateishi Y, Hisaeda H, Nishiuchi Y, Harada N, Kobayashi K, Matsumoto S
Organizer
U.S.-Japan Cooperative Medical Sciences Program : 45th Tuberculosis and Leprosy Research Conference
Place of Presentation
Boston, USA
Year and Date
2010-07-13
Related Report
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