Analysis of physiological role of acidic sphingomyelinase induced by electrophiles
| Project/Area Number |
21790132
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
KUMAGAI Takeshi Kitasato University, 薬学部, 助教 (30365184)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ストレス / スフィンゴ脂質 / 炎症 / 脂質ラフト |
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| Research Abstract |
In this study, we investigated the role of acidic sphingomyelinase (ASMase) induced by electrophile, which is contained in environmental pollutant and has a potential to induce cell injury, focusing on cell injury and inflammatory response. As a result, we demonstrated that electrophie-induced ASMase involves in 1) the induction of cell death, in particular apoptosis 2) the enhancement of cell susceptibility to proinflammatory cytokines.
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Report
(3 results)
Research Products
(12 results)
