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Elucidation of drug resistance mechanism indicated by DNA methylation in colon cancer

Research Project

Project/Area Number 21790140
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Medical pharmacy
Research InstitutionUniversity of Tsukuba

Principal Investigator

SUZUKI Hideo  筑波大学, 医学医療系, 准教授 (00400672)

Research Collaborator WATANABE Yoshiyuki  聖マリアンナ医科大学, 消化器肝臓内科, 講師 (90329243)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsオーダーメード医療 / DNAメチル化 / 消化器癌 / 化学療法 / 内視鏡的治療 / 内視鏡治療 / 癌
Research Abstract

(1)The SNP of EGFR D944D in Exon25 was statistically correlated with the expression of skin toxicity in unresectable colorectal cancer patients administrated anti-EGFR antibody, suggesting that application to personalized medication that enables the prediction of this side effect.
(2)By comprehensive analysis of DNA methylation in gastric washes before and after endoscopic treatment, methylation in MINT25 and SOX17 gene was reduced significantlyafter treatment with curative resection in early gastric cancer patients. This method may be useful for early detection of recurrence after endoscopic treatment.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (16 results)

All 2012 2011 2010 2007

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (9 results) Book (1 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Hypermethylation of Sox17 gene is useful as a molecular diagnostic application in early gastric cancer.2012

    • Author(s)
      Watanabe Y et al
    • Journal Title

      Tumour Biol

      Volume: 33(2) Issue: 2 Pages: 383-93

    • DOI

      10.1007/s13277-011-0278-y

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-scale DNA methylation analysis in GI cancers2012

    • Author(s)
      渡邊嘉行、鈴木英雄
    • Journal Title

      SEIBUTSU BUTSURI KAGAKU

      Volume: 56 Issue: 1 Pages: 5-8

    • DOI

      10.2198/sbk.56.5

    • NAID

      130004456514

    • ISSN
      0031-9082, 1349-9785
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA Methylation Profiles of Primary Colorectal Carcinoma and Matched Liver Metastasis2011

    • Author(s)
      Watanabe Y, et al.
    • Journal Title

      PLoS One

      Volume: 6 Issue: 11 Pages: e27889-e27889

    • DOI

      10.1371/journal.pone.0027889

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA methylation of interferon regulatory factors in gastric cancer and noncancerous gastric mucosae.2010

    • Author(s)
      Yamashita M, Watanabe Y, et al.
    • Journal Title

      Cancer Sci.

      Volume: 101 Issue: 7 Pages: 1708-1716

    • DOI

      10.1111/j.1349-7006.2010.01581.x

    • NAID

      10026594987

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA methylation of interferon regulatory factors in gastric cancer and noncancerous gastric mucosae.2010

    • Author(s)
      Yamashita M, Watanabe Y, et al.
    • Journal Title

      Cancer Science

      Volume: 101 Pages: 1708-1716

    • NAID

      10026594987

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 胃洗浄廃液を用いた胃がんメチル化マーカーの探索2012

    • Author(s)
      渡邊嘉行
    • Organizer
      第23回日本消化器癌発生学会総会
    • Place of Presentation
      徳島
    • Year and Date
      2012-11-16
    • Related Report
      2012 Final Research Report
  • [Presentation] The Sox17 Gene Hypermethylation is Useful as a Molecular Diagnostic Application in Early Stage of Gastric Cancer.2012

    • Author(s)
      Hama R, Watanabe Y et al.
    • Organizer
      American Association for Cancer Research 2012
    • Place of Presentation
      Chicago IL.(USA)
    • Year and Date
      2012-04-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 胃洗浄廃液を用いた胃がんメチル化マーカーの探索2012

    • Author(s)
      渡邊嘉行
    • Organizer
      第23回日本消化器癌発生学会総会
    • Place of Presentation
      徳島
    • Related Report
      2012 Annual Research Report
  • [Presentation] 早期胃がんESD後補助診断としての胃洗浄廃液診断の有用性2011

    • Author(s)
      渡邊嘉行, ら
    • Organizer
      第97回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Usefulness of DNA methylation analysis using gastric washes as a treatment marker for early gastric cancer2011

    • Author(s)
      Watanabe Y et al
    • Organizer
      American Association for Cancer Research 2011
    • Place of Presentation
      Orland FL.(USA)
    • Year and Date
      2011-04-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Usefulness of DNA methylation analysis using gastric washes as a treatment marker for early gastric cancer2011

    • Author(s)
      Watanabe Y, et al.
    • Organizer
      American Association for Cancer Research
    • Place of Presentation
      Orland (USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Usefulness of DNA methylation analysis using gastric washes as a treatment marker for early gastric cancer2011

    • Author(s)
      Watanabe Y, et al.
    • Organizer
      Digestive Disease Week
    • Place of Presentation
      Chicago (USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 消化器内視鏡検査と分子生物学的診断の新たな展開2010

    • Author(s)
      細谷浩介、渡邊嘉行
    • Organizer
      JDDW2010シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2010-10-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 消化器内視鏡検査と分子生物学的診断の新たな展開2010

    • Author(s)
      細谷浩介、渡邊嘉行, 他
    • Organizer
      JDDW2010 シンポジウム
    • Place of Presentation
      パシフィコ横浜展示ホール
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report
  • [Book] エピジェネティックと大腸癌2011

    • Author(s)
      渡邊嘉行
    • Total Pages
      6
    • Publisher
      BIO Clinica
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 胃粘膜洗浄液を利用した疾患関連マーカー検出方法2007

    • Inventor(s)
      学校法人聖マリアンナ医科大学、北海道公立大学法人札幌医科大学
    • Industrial Property Rights Holder
      渡邊 嘉行、豊 田 実、今 井 浩三、篠村 恭久、伊東 文生、時野 隆至
    • Filing Date
      2007-05-15
    • Related Report
      2012 Final Research Report
    • Overseas

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Published: 2009-04-01   Modified: 2019-07-29  

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