Investigation of PET probes for the functional analysis of drug transporters
| Project/Area Number |
21790171
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
TAKASHIMA Tadayuki The Institute of Physical and Chemical Research, 分子プローブ動態応用研究チーム, 研究員 (80469907)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | Positron Emission Tomography(PET) / 薬物トランスポーター / 肝胆系輸送 / 腎排泄 / Abcg2 / Celecoxib / Positron Emission Tomography (PET) |
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| Research Abstract |
After a number of PET image analyses with several kinds of PET probes, we found carbon-11 labeled SC-62807 ([^<11>C]SC-62807), one of the metabolites of Celecoxib. PET image analysis revealed that [^<11>C]SC-62807 was excreted into bile and urine without metabolism in normal mice, which were drastically decreased in Bcrp knockout mice. The present study in mice demonstrated the feasibility of the PET studies with [^<11>C]SC-62807 for the functional analysis of Bcrp in human.
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Report
(3 results)
Research Products
(2 results)
