Studies on the biodistribution, biodegradation and half-lives of Fc domain-containing proteins.
| Project/Area Number |
21790172
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
SUZUKI Takuo 国立医薬品食品衛生研究所, 生物薬品部, 主任研究官 (10415466)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 薬物動態 / 代謝学 / FcRn / Fc受容体 / 半減期 / 分布 / 抗体医薬品 |
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| Research Abstract |
To elucidate the influences of the affinity to neonatal Fc receptor(FcRn) of Fc domain-containing proteins on their biodistribution and biodegradation, the accumulation of several fluorescent-labeled Fc domain-containing proteins were analyzed in mice. The accumulation ratio of the labeled proteins in liver and lung was altered by lowering their affinity to FcRn. Therefore, in the development of therapeutic antibodies, it seems to be necessary to consider that the structural modification of antibodies which leads to an alteration in the affinity to FcRn may change their biodistribution.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Genetic polymorphisms of FCGRT encoding FcRn in a Japanese population and their functional analysis2010
Author(s)
Ishii-Watabe A, Saito Y, Suzuki T, Tada M, Ukaji M, Maekawa K, Kurose K, Kaniwa N, Sawada JI, Kawasaki N, Yamaguchi T, Eguchi Nakajima T, Kato K, Yamada Y, Shimada Y, Yoshida T, Ura T, Saito M, Muro K, Doi T, Fuse N, Yoshino T, Ohtsu A, Saijo N, Hamaguchi
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Journal Title
Drug Metab Pharmacokinet
Volume: 25
Pages: 578-587
NAID
URL
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