Functional analysis of Jmjd5, a candidate tumor suppressor gene, for angiogenesis, hematopoiesis and tumorigenesis.
Project/Area Number |
21790178
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
General anatomy (including Histology/Embryology)
|
Research Institution | Kanazawa University |
Principal Investigator |
ISHIMURA Akihiko Kanazawa University, がん研究所, 助教 (80375261)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 癌 / 遺伝子 / 発生・分化 / 細胞増殖 |
Research Abstract |
In order to identify novel cancer-related genes, we have performed the retroviral insertional mutagenesis in mice, resulting in identification of Jmjd5, a histone demethylase. In this study, we have generated Jmjd5-deficient mice to investigate in vivo role of Jmjd5. Our results showed that Jmjd5 was involved in embryonic cell proliferation and that Cdkn1a might be one of Jmjd5 targets.
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Report
(3 results)
Research Products
(12 results)