• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role of arginine-methyltransferase for quality control of protein maturation

Research Project

Project/Area Number 21790181
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General anatomy (including Histology/Embryology)
Research InstitutionOsaka University

Principal Investigator

MATSUZAKI Shinsuke  Osaka University, 連合小児発達学研究科, 准教授 (60403193)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords小胞体ストレス / アルギニンメチル化酵素 / タンパク質品質管理 / ジメチルアルギニン / PRMT1 / 蛋白質品質管理
Research Abstract

We discovered upregulation of Protein Arginine Methyltransferases (PRMT) under endoplasmic reticulum (ER) stress condition. Protein level of PRMT1 is increased by ER stressor tunicamycin, time-dependently. PRMT1 is upregulated by XBP1 overexpression. In contrast, cells knocked-down (KD) of PRMT1 showed increase of ER-chaperone GRP78 under untreated condition (non-stress condition). Moreover, these cells cause abnormal localization Golgi complex, resulting increase of the Golgi-related proteins such as GM130, TGN38, Fut8. Finally, to transfect PRMT1-YFP into PRMT1-KD cells, the abnormal accumulation of Golgi complex was recovered.These results suggest that PRMT1 regulates the structure and the function of Golgi complex, associated to ER function.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (41 results)

All 2011 2010 2009

All Journal Article (23 results) (of which Peer Reviewed: 23 results) Presentation (18 results)

  • [Journal Article] Reduced rate of neural differentiation in the dentate gyrus of adult dysbindin null (Sandy) mouse.2011

    • Author(s)
      Nihonmatsu-Kikuchi N, Hashimoto R, Hattori S, Matsuzaki S, Shinozaki T, Miura H, Ohota S, Tohyama M, Takeda M, Takebayashi Y
    • Journal Title

      PLoS ONE. 6(1)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Familiar amyotrophic lateral sclerosis (FALS)-linked SOD1 mutation accelerates neuronal cell death by activating cleavage of caspase-4 under ER stress in an in vitro model of FALS.2010

    • Author(s)
      Koyama Y, Hiratsuka T, Matsuzaki S, Yamagishi S, Kato S, Katayama T, Tohyama M.
    • Journal Title

      Neurochem Int.(equally contributed author) 57(7)

      Pages: 838-43

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Yokukansan inhibits neuronal death during ER stress by regulating the unfolded protein response.2010

    • Author(s)
      Hiratsuka T, Matsuzaki S, その他6名(8人中2番目)
    • Journal Title

      PLoS ONE.(corresponding author and equally contributed author) 5(10)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] bFGF regulates PI3-kinase-Rac1-JNK pathway and promotes fibroblast migration in wound healing.2010

    • Author(s)
      Kanazawa S, Fujiwara T, Matsuzaki S, Shingaki K, Taniguchi M, その他6名(11人中3番目).
    • Journal Title

      PLoS ONE. 5(8)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanism of kallikrein-related peptidase 8/neuropsin-induced hyperkeratosis in inflamed skin.2010

    • Author(s)
      Shingaki K, Matsuzaki S, Taniguchi M, Kubo T, その他9名(13人中2番目)
    • Journal Title

      Br J Dermatol.(equally contributed author) 163(3)

      Pages: 466-75

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] DISC1 regulates cell-cell adhesion, cell-matrix adhesion and neurite outgrowth.2010

    • Author(s)
      Hattori T, Shimizu S, Koyama Y, Yamada K, Kuwahara R, Kumamoto N, Matsuzaki S, Ito A, Katayama T, Tohyama M.
    • Journal Title

      Molecular Psychiatry 15(8)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dysbindin regulates the transcriptional level of myristoylated alanine-rich protein kinase C substrate via the interaction with NF-YB in mice brain.2010

    • Author(s)
      Okuda H, Kuwahara R, Matsuzaki S, Miyata S, Kumamoto N, Hattori T, Shimizu S, Yamada K, Kawamoto K, Hashimoto R, Takeda M, Katayama T, Tohyama M.
    • Journal Title

      PLoS ONE.(corresponding author and equally contributed author) 5(1)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased stathminl expression in the dentate gyrus of mice causes abnormal axonal arborizations.2010

    • Author(s)
      Yamada K, Matsuzaki S, Hattori T, Kuwahara R, Taniguchi M, Hashimoto H, Shintani N, Baba A, Kumamoto N, Yamada K, Yoshikawa T, Katayama T, Tohyama M.
    • Journal Title

      PLoS ONE. 5(1)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Caspase-4 is partially cleaved by calpain via the impairment of Ca2+ homeostasis under the ER stress.2010

    • Author(s)
      Matsuzaki S, Hiratsuka T, Kuwahara R, Katayama T, Tohyama M.
    • Journal Title

      Neurochem Int.(First author and corresponding author) 56(2)

      Pages: 352-6

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced rate of neural differentiation in the dentate gyrus of adult dysbindin null (sandy) mouse2010

    • Author(s)
      Nihonmatsu-Kikuchi N, Hashimoto R, Hattori S, Matsuzaki S, et.al.
    • Journal Title

      PLoS ONE

      Volume: 6(1)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Yokukansan inhibits neuronal death during ER stress by regulating the unfolded protein response2010

    • Author(s)
      Hiratsuka T, Matsuzaki S, et.Al.
    • Journal Title

      PLos ONE

      Volume: 5(10)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Familiar Amyotrophic Lateral Sclerosis (FALS)-linked SOD1 Mutation Accelerates Neuronal Cell Death by Activating Cleavage2010

    • Author(s)
      Koyama Y, Hiratsuka T, Matsuzaki S, et.al.
    • Journal Title

      Neurochemistry International

      Volume: 57(7) Pages: 838-43

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] bFGF regulates PI3-kinase-Rac1-JNK pathway and promotes fibroblast migration in wound healing2010

    • Author(s)
      Kanazawa S, Fujiwara T, Matsuzaki S, et.al.
    • Journal Title

      PLoS ONE

      Volume: 5(8)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanism of kallikrein-related peptidase 8/neuropsin-induced hyperkeratosis in inflamed skin2010

    • Author(s)
      Shingaki K, Matsuzaki S, et.al.
    • Journal Title

      British Journal of Dermatology

      Volume: 163(3) Pages: 466-75

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DISC1 regulates cell-cell adhesion, cell-matrix adhesion and neurite outgrowth.2010

    • Author(s)
      Hattori T, Shimizu S, Koyama Y, Yamada K, Kuwahara R, Kumamoto N, Matsuzaki S, et.al.
    • Journal Title

      Molecular Psychiatry

      Volume: 15(8)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Caspase-4 is partially cleaved by calpain via the impairment of Ca(2+) homeostasis under the ER stress.2010

    • Author(s)
      Matsuzaki S, Hiratsuka T, Kuwahara R, Katayama T, Tohyama M.
    • Journal Title

      Neurochem Int. 56(2)

      Pages: 352-356

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased stathminl expression in the dentate gyrus of mice causes a bnormal axonal arborizations.2010

    • Author(s)
      Yamada K, Matsuzaki S, Hattori T, Kuwahara R, Taniguchi M, Hashimoto H, Shintani N, Baba A, Kumamoto N, Yamada K, Yoshikawa T, Katayama T, Tohyama M
    • Journal Title

      PLoS One. 5(1)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dysbindin regulates the transcriptional level of myristoylated alanine-rich protein kinase C substrate via the interaction with NF-YB in mice brain.2010

    • Author(s)
      Okuda H, Kuwahara R, Matsuzaki S Miyata S, Kumamoto N, Hattori T, Shimizu S, Yamada K, Kawamoto K, Hashimoto R, Takeda M, Katayama T, Tohyama M.
    • Journal Title

      PLoS One. 5(1)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of the PACAP-PAC1-DISC1 and PACAP-PAC1-stathminl systems in schizophrenia and bipolar disorder : novel treatment mechanisms?2009

    • Author(s)
      Katayama T, Hattori T, Yamada K, Matsuzaki S, Tohyama M.
    • Journal Title

      Pharmacogenomics. 1967-78

      Pages: 1967-78

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pericentrin, a centrosomal protein related to microcephalic primordial dwarfism, is required for olfactory cilia assembly in mice.2009

    • Author(s)
      Miyoshi K, Kasahara K, Miyazaki I, Shimizu S, Taniguchi M, Matsuzaki S, Tohyama M, Asanuma M.
    • Journal Title

      FASEB J. 23(10)

      Pages: 3289-97

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association studies and gene expression analyses of the DISCl-interacting molecules, pericentrin 2 (PCNT2) and DISCl-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder.2009

    • Author(s)
      Anitha A, Nakamura K, Yamada K, Iwayama Y, Toyota T, Takei N, Iwata Y, Suzuki K, Sekine Y, Matsuzaki H, Kawai M, Thanseem I, Miyoshi K, Katayama T, Matsuzaki S, Baba K, Honda A, Hattori T, Shimizu S, Kumamoto N, Kikuchi M, Tohyama M, Yoshikawa T, Mori N.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 150B(7)

      Pages: 967-76

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association studies and gene expression analyses of the DISC1-interac ting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder.2009

    • Author(s)
      Anitha A, Nakamura K, Yamada K, Iwayama Y, Toyota T, Takei N, Iwata Y, Suzuki K, Sekine Y, Matsuzaki H, Kawai M, Thanseem I, Miyoshi K, Katayama T, Matsuzaki S, Baba K, Honda A, Hattori T, Shimizu S, Kumamoto N, Kikuchi M, Tohyama M, Yoshikawa T, Mori N.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 150B(7)

      Pages: 967-976

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of the PACAP-PAC1-DISC1 and PACAP-PAC1-stathminl systems in schizophrenia and bipolar disorder : novel treatment mechanisms?2009

    • Author(s)
      Katayama T, Hattori T, Yamada K, Matsuzaki S, Tohyama M.
    • Journal Title

      Pharmacogenomics. 10(12)

      Pages: 1967-1978

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Neuronal sumoylation and its contributions to form, function and neurodegenerative diseases2011

    • Author(s)
      Matsuzaki S, et al.
    • Organizer
      The 10th International Conference on Alzheimer's and Parkinson's Diseases (AD/PD 2011 )
    • Place of Presentation
      CCIB Convention Center, Barcelona (Spain)
    • Year and Date
      2011-03-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] SUMO1 Conjugates Indentified in an Over-expressing Transgenic Mouse Model and their Links to Disease and Synaptic Function2011

    • Author(s)
      Shinsuke Matsuzaki, Taiichi Katayama, Masaya Tohyama, Brian Raught, Paul Fraser
    • Organizer
      The 10th International Conference on Alzheimer's and Parkinson's Diseases.
    • Place of Presentation
      バルセロナ
    • Related Report
      2010 Final Research Report
  • [Presentation] DISC1 regulates cell-cell adhesion, cell-matrix adhesion and neurite outgrowth.2010

    • Author(s)
      Hattori T, Shimizu S, Yamada K, Kuwahara R, Matsuzaki S, et al.
    • Organizer
      International Symposium "DISC1 2010" (Edinburgh)
    • Place of Presentation
      Edinburgh First John McIntyre Conference Centre, Edinburgh, Scotland(UK)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Analysis of Protein Arginine Methyltrasferase under ER stress.2010

    • Author(s)
      桑原隆亮、松崎伸介、他.
    • Organizer
      第53回日本神経化学会大会(Neuro2010)
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] DISC1 regulates cell-cell adhesion, cell-matrix adhesion and neurite outgrowth2010

    • Author(s)
      Hattori T, Shimizu S, Yamada K, Kuwahara R, Matsuzaki S
    • Organizer
      International Symposium "DISC1 2010"(Edinburgh)
    • Place of Presentation
      Edinburgh First John Mc Intyre Conference Centre, Edinburgh, Scotland (UK)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 海馬歯状回でのstathmin1の増加は異常な軸索伸展を惹起する2010

    • Author(s)
      山田浩平、松崎伸介, 他
    • Organizer
      第53回日本神経化学会大会(Neuro2010)
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Inhibitory effect of Ferulic acid against ER stress could suggest the clinical validity of Yokukansan, a Japanese herbal medicine.2010

    • Author(s)
      平塚徹、松崎伸介, 他
    • Organizer
      第53回日本神経化学会大会(Neuro2010)
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 抑肝散に含まれるフェルラ酸はERストレスによる神経細胞死を抑制する2010

    • Author(s)
      平塚徹、松崎伸介, 他.
    • Organizer
      第27回和漢医薬学会学術大会
    • Place of Presentation
      京都薬科大学(京都市)
    • Year and Date
      2010-08-29
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Brian Raught and Paul Fraser., Neuronal Sumoylation and Its Contributions to Form, Function and Disease、EMBO Workshop, Proteolysis & Neurodegeneration2010

    • Author(s)
      Shinsuke Matsuzaki, Taiichi Katayama, Masaya Tohyama, Brian Raught, Paul Fraser.
    • Organizer
      5th Inproteolys Meeting
    • Place of Presentation
      マドリッド
    • Related Report
      2010 Final Research Report
  • [Presentation] 小胞体ストレスを起源とするアルツハイマー氏病発症機構への抑肝散の効果2009

    • Author(s)
      平塚徹, 松崎伸介, 宮田信吾, 片山泰一, 遠山正彌
    • Organizer
      第32回 神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] ERストレス下での翻訳後修飾2009

    • Author(s)
      桑原隆亮, 松崎伸介, 服部剛志, 森泰丈, 河本恵介, 清水尚子, 山田浩平, 片山泰一, 遠山正彌
    • Organizer
      第32回 神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] DISC1の細胞接着性への影響の検討2009

    • Author(s)
      服部剛志, 清水尚子, 山田浩平, 桑原隆亮, 大野浩司, 松崎伸介, 片山泰一, 伊藤彰, 遠山正彌
    • Organizer
      第32回 神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 統合失調症関連因子PACAPによる神経分化調節機構の解析2009

    • Author(s)
      山田浩平、松崎伸介、服部剛志、橋本均、新谷紀人、馬場明道、片山泰一、遠山正彌
    • Organizer
      第52回日本神経化学会-日本生物学的精神学会合同シンポジウム
    • Place of Presentation
      渋川(群馬県)
    • Year and Date
      2009-06-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] ERストレス下での翻訳後修飾2009

    • Author(s)
      桑原隆亮, 松崎伸介, 服部剛志, 森泰丈, 河本恵介, 清水尚子, 山田浩平, 片山泰一, 遠山正彌
    • Organizer
      第32回神経科学大会
    • Place of Presentation
      名古屋市
    • Related Report
      2010 Final Research Report
  • [Presentation] 小胞体ストレスを起源とするアルツハイマー氏病発症機構への抑肝散の効果2009

    • Author(s)
      平塚徹, 松崎伸介, 宮田信吾, 片山泰一, 遠山正彌
    • Organizer
      第32回神経科学大会
    • Place of Presentation
      名古屋市
    • Related Report
      2010 Final Research Report
  • [Presentation] DISC1の細胞接着性への影響の検討2009

    • Author(s)
      服部剛志, 清水尚子, 山田浩平, 桑原隆亮, 大野浩司, 松崎伸介, 片山泰一, 伊藤彰, 遠山正彌
    • Organizer
      第32回神経科学大会
    • Place of Presentation
      名古屋市
    • Related Report
      2010 Final Research Report
  • [Presentation] 統合失調症関連因子PACAPによる神経分化調節機構の解析2009

    • Author(s)
      山田浩平、松崎伸介、服部剛志、橋本均、新谷紀人、馬場明道、片山泰一、遠山正彌
    • Organizer
      第52回日本神経化学会シンポジウム
    • Place of Presentation
      渋川市
    • Related Report
      2010 Final Research Report
  • [Presentation] 統合失調症脆弱性遺伝子ディスバインジンと記憶との関連:ヒトと動物モデルの表現型の検討2009

    • Author(s)
      橋本亮太、高雄啓三、服部聡子、室谷知孝、遠山桂子、中西和男、松崎伸介、石塚智子、熊本奈都子、高村明孝、大井一高、福本素由己、山森英長、安田由華、遠山正彌、大和谷厚、功刀浩、宮川剛、武田雅俊
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      京都市
    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi