Analysis on molecular mechanisms of cell differentiation from neural stem cells to specific neurons and glia
| Project/Area Number |
21790183
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Kumamoto University |
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Principal Investigator |
TAKEBAYASHI Hirohide Kumamoto University, 大学院・生命科学研究部, 准教授 (60353439)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 細胞分化 / 組織形成 / オリゴデンドロサイト / 運動ニューロン / 転写因子 / 結合因子 / プロテオミクス / 酵母2ハイブリッドスクリーニング / エレクトロポレーション / ノックアウトマウス / Olig / 神経細胞 / グリア細胞 / 神経幹細胞 |
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| Research Abstract |
Olig2 is basic helix-loop-helix transcription factor essential for motoneuron and oligodendrocyte development. In order to investigate Olig transcription complex, which regulates differentiation from neural stem cell to specific subtype of neuron and glial cells, we screened Olig2-binding factors. We identified two factors, which are named Olig Binding Protein1 (OBP1), Olig Binding Protein2 (OBP2). Furthermore, we identified Olig2 as a phospho-protein and its phosphorylation sites. We revealed transcriptional regulation of Olig2 transcription factor.
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Report
(3 results)
Research Products
(16 results)
