Morphological study on the cell membrane kinetics in gastric parietal cells associated with gastric acid secretion.
Project/Area Number |
21790185
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
General anatomy (including Histology/Embryology)
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Research Institution | University of Miyazaki |
Principal Investigator |
SAWAGUCHI Akira University of Miyazaki, 医学部, 教授 (30336292)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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Keywords | 高圧凍結技法 / 胃底腺 / 超微形態 / 壁細胞 / プロトンポンプ / 単離胃粘膜 / 回復期 |
Research Abstract |
To elucidate a functional transformation of gastric parietal cells, we have newly developed an isolated rat gastric mucosa model whose parietal cells exhibited a reverting process from the active to resting state of acid secretion. Immunohistochemistry of H^+/K^+-ATPase demonstrated a progressive translocation of H^+/K^+-ATPase from the apical to the cytoplasmic region. In the reverting process, the apical membranes were internalized into the cytoplasm forming unique penta-laminar membranes which were labeled for autophagosome-marker LC3. This finding suggested an association of autophagy with the reverting process in the gastric parietal cell.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Transcripts analysis of infective larvae of an intestinal nematode, Stongyloides venezuelensis.2011
Author(s)
Yoshida, A., Nagayasu, E., Nishimaki, A., Sawaguchi, A., Yanagawa, S., Maruyama, H.
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Journal Title
Parasitol Int
Volume: 60
Pages: 75-83
Related Report
Peer Reviewed
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