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Effects of extracelluIar chloride on regulatory mechanisms of the epithelial sodium channels

Research Project

Project/Area Number 21790210
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General physiology
Research InstitutionFukuoka University

Principal Investigator

YAMADA Toshiki  Fukuoka University, 学長付, 助教 (10453101)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsナトリウム輸送 / ENaC / クロライドイオン / パッチクランプ / Na^+輸送 / 電気生理学
Research Abstract

To determine regulatory mechanisms of epithelial sodium channels by extracellular chloride, electrophysiological experiments were performed with distal nephrone epithelial cells from Xenopus larvls, A6 cells. Lowing extracellular Cl^- concentration decreased mean open time and open probability of ENaC. These results suggest that extracellular Cl^- plays a key role in control of the ENaC-mediated Na^+ reabsorption.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2011 2010 2009

All Journal Article (8 results) (of which Peer Reviewed: 7 results) Presentation (4 results) Book (1 results)

  • [Journal Article] NaCl flux between apical and basolateral side recruits claudin-1 to tight junction strands and regulate paracellular transport.2010

    • Author(s)
      Tokuda S, Miyazaki H, Nakajima K, Yamada T, Marunaka Y.
    • Journal Title

      Biochem Biophys Res Commun 393(3)

      Pages: 390-396

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of sodium, calcium, and magnesium transport in the renal distal tubule.2009

    • Author(s)
      Yamada T, Kita S, Iyoda T, Yamamoto S, Iwamoto T.
    • Journal Title

      Med.Bull.Fukuoka Univ 36(4)

      Pages: 257-262

    • NAID

      110007376606

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of C1 channels and transporters in cardiac cell volume homeostasis.2009

    • Author(s)
      Yamamoto S, Yamada T, Iyoda T, Kita S, Iwamoto T.
    • Journal Title

      Med.Bull.Fukuoka Univ 36(4)

      Pages: 243-255

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hydrostatic pressure regulates tight junctions, actin cytoskeleton and transcellularion transport.2009

    • Author(s)
      Tokuda S, Miyazaki H, Nakajima K, Yamada T, Marunaka Y.
    • Journal Title

      Biochem Biophys Res Commun. 390(4)

      Pages: 1315-1321

    • Related Report
      2010 Final Research Report
  • [Journal Article] Regulation of paracellular NH^+ and C1 conductances by hydrostatic pressure.2009

    • Author(s)
      Tokuda S, Niisato N, Nagai T, Taruno A, Nakajima K, Miyazaki H, Yamada T, Hosogi S, Ohta M, Nishio K, Iwasaki Y, Marunaka Y.
    • Journal Title

      Cell Biol Int. 33(9)

      Pages: 949-956

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of chloride ion on epithelial sodium channels (ENaC) in AVT-stimulated renal epithelial cells.2009

    • Author(s)
      Yamada T, Niisato N, Marunaka Y.
    • Journal Title

      J Physiol Sci 59 Suppl 1

      Pages: 295-295

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of extracellular chloride ion on epithelial sodium channel (ENaC) in arginine vasotocin (AVT)-stimulated renal epithelial cells.2009

    • Author(s)
      Yamada T, Niisato N, Marunaka Y.
    • Journal Title

      Biomed Res 30(3)

      Pages: 193-198

    • NAID

      130004470752

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of extracellular chloride ion on epithelial sodium channel(ENaC)in arginine vasotocin(AVT)-stimulated renal epithelial cells2009

    • Author(s)
      Toshiki Yamada
    • Journal Title

      Biomedical Research 30(3)

      Pages: 193-198

    • NAID

      130004470752

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 2種のカエル腹皮のイオン輸送におけるバソトシンの作用2009

    • Author(s)
      山田敏樹、内山実、岩本隆宏
    • Organizer
      トランスポーター研究会第3回几州部会
    • Place of Presentation
      鹿児島
    • Year and Date
      2009-11-21
    • Related Report
      2010 Final Research Report
  • [Presentation] 腎上皮細胞の抗利尿ホルモン促進性Na^+輸送における細胞外C1の影響2009

    • Author(s)
      山田敏樹、新里直美、丸中良典、岩本隆宏
    • Organizer
      TRANSPOTSOME平成21年度第1回班会議
    • Place of Presentation
      熊本
    • Year and Date
      2009-08-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Effect of chloride ion on epithelial sodium channels (ENaC) in AVT-stimulated renal epithelial cells.2009

    • Author(s)
      Yamada T, Niisato N, Marunaka Y.
    • Organizer
      The 36^<th> Congress of the International Union of Physiological Sciences
    • Place of Presentation
      京都
    • Year and Date
      2009-07-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of chloride ion on epithelial sodium channels(ENaC)in arginine vasotocin(AVT)-stimulated renal epithelial cells2009

    • Author(s)
      Toshiki Yamada
    • Organizer
      The XXXVI International Congress of Physiological Sciences
    • Place of Presentation
      京都
    • Year and Date
      2009-07-29
    • Related Report
      2009 Annual Research Report
  • [Book] In : Frogs : Biology, Ecology and Uses.(Hormonal regulation of ion transports in frog epithelia-Measurements of ion transport in frog epithelium using electrophysiological techniques)(Editor James L.Murray.)ISBN:978-1-61324-667-22011

    • Author(s)
      Yamada T, Uchiyama M.
    • Publisher
      Nova science Publishers
    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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