Binding molecules modify cold sensing activities of TRPM8 channel multimer complex
Project/Area Number |
21790222
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
General physiology
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Research Institution | 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設) (2010) National Institutes of Natural Sciences Okazaki Research Facilities (2009) |
Principal Investigator |
UMEMURA Toru 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 特別協力研究員 (40533782)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 分子 / 細胞生理学 / 生理学 |
Research Abstract |
This project aims to reveal how themoreceptors sense temperature. We found supporting evidence that cold receptors, TRPM8 form net structures in the raft. One of the TRPM8 short variants promoted TRPM8 to move to plasmamembrane. Additionally, it is strongly suggested that a TRPM8 short variant binds to original TRPM8, resulting in producing various sizes of TRPM8 aggregates. This may be the reason why cells co-expressing TRPM8 and TRPM8 short variant show wider range of temperature threshold.
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Report
(3 results)
Research Products
(4 results)