Orthostatic tolerance and blood flow during a heat stress

• Project/Area Number: 21790225
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Nara Women's University
• Principal Investigator: SHIBASAKI Manabu Nara Women's University, 人間文化研究科, 准教授 (00314526)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 暑熱負荷 / 皮膚血管収縮反応性 / 皮膚血管拡張 / 起立耐性 / 血液貯留 / マイクロダイアリシス / 起立性耐性

Research Abstract

This study was focused on control of lower leg blood flow during an orthostatic challenge of heat-stressed individuals. Cutaneous vasoconstrictor responsiveness was assessed by multiple doses of exogenous norepinephrine and veno-arteriolar reflex on dorsal forearm and lower leg. Venous compliance and microvascular filtration coefficient were measured by strain-gauge plethysmography during 10mmHg pressure step test and during 20mmHg lower body negative pressure. These variables were reduced in the hyperthermic condition. In luteal phase, venous compliance and microvascular filtration were increased and orthostatic tolerance was reduced.

Research Products

• [Journal Article] Modelflow underestimates cardiac output in heat stressed individuals. (2011)
  • Author(s): Shibasaki M(ほか5名、1番目)
  • Journal Title: Am J Physiol Regul Integr Comp Physiol. 300(2)
  • Peer Reviewed
• [Journal Article] Modelflow underestimates cardiac output in heat stressed individuals (2011)
  • Author(s): Shibasaki M, et al.
  • Journal Title: Am J Physiol Regul Integr Comp Physiol Volume: 300(2)
  • Peer Reviewed
• [Journal Article] Heatstress attenuates the increase in arterial blood pressure during the cold pressor test. (2010)
  • Author(s): Cui J, Shibasaki M(ほか4名、2番目)
  • Journal Title: J Appl Physiol. 109(5) Pages: 1354-1359
  • Peer Reviewed
• [Journal Article] Skin blood flowand local temperature independently modify sweat rate during passive heat stress in humans. (2010)
  • Author(s): Wingo JE(ほか5名、5番目).
  • Journal Title: J Appl Physiol. 109(5) Pages: 1301-1306
  • Peer Reviewed
• [Journal Article] Insufficient cutaneous vasoconstriction leading up to and during syncopal symptoms in the heat stressed human. (2010)
  • Author(s): Crandall CG, Shibasaki M, Wilson TE.
  • Journal Title: Am J Physiol Heart Circ Physiol. 299(4)
  • Peer Reviewed
• [Journal Article] Mechanisms and controllers of eccrine sweating in humans. (2010)
  • Author(s): Shibasaki M, Crandall CG.
  • Journal Title: Frontier Bioscience Scholar Edition 2 Pages: 685-696
  • Peer Reviewed
• [Journal Article] Insufficient cutaneous vasoconstriction leading up to and during syncopal symptoms in the heat stressed human (2010)
  • Author(s): Crandall CG, Shibasaki M, Wilson TE
  • Journal Title: Am J Physiol Heart Cire Physiol. Volume: 299(4)
  • Peer Reviewed
• [Journal Article] 運動時の発汗反応-皮内マイクロダイアリシスと発汗に関する研究への応用- (2009)
  • Author(s): 芝崎学
  • Journal Title: 発汗学 16(2) Pages: 58-62
• [Journal Article] Plasmahyperosmolality elevates the internal temperature threshold for active thermoregulatory vasodilation during heat stress in humans. (2009)
  • Author(s): Shibasaki M(ほか4名、1番目)
  • Journal Title: Am J Physiol Regul Integr Comp Physiol. 297(6)
  • Peer Reviewed
• [Journal Article] Botulinum toxin abolishes sweating via impaired sweat gland responsiveness to exogenous acetylcholine. (2009)
  • Author(s): Shibasaki M(ほか5名、1番目)
  • Journal Title: Br J Dermatol. 161(4) Pages: 757-761
  • Peer Reviewed
• [Journal Article] Sustained impairments in cutaneous vasodilation and sweating in grafted skin following long term recovery. (2009)
  • Author(s): Davis SL, Shibasaki M(ほか8名、2番目)
  • Journal Title: J Burn Care Res. 30(4) Pages: 675-85
  • Peer Reviewed
• [Journal Article] Neural and non-neural control of skin blood flow during isometric handgrip exercise in the heat stressed human. (2009)
  • Author(s): Shibasaki M(ほか3名、1番目)
  • Journal Title: J Physiol (Lond). 587(9) Pages: 2101-2107
  • Peer Reviewed
• [Journal Article] Wholebody heat stress attenuates baroreflex control of muscle sympathetic nerve activity during post exercise muscle ischemia. (2009)
  • Author(s): Cui J, Shibasaki M(ほか3名、2番目)
  • Journal Title: J Appl Physiol. 106(4) Pages: 1125-1131
  • Peer Reviewed
• [Presentation] 暑熱負荷時のModelflow による心拍出量推定の妥当性 (2010)
  • Author(s): 芝崎学
  • Organizer: 生気象学会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-06
• [Presentation] 暑熱負荷時のModelflowによる心拍出量推定の妥当性 (2010)
  • Author(s): 柴崎学
  • Organizer: 生気象学会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-06
• [Presentation] 発汗と皮膚血流の温熱生理学からみた被服衛生学 (2010)
  • Author(s): 芝崎学
  • Organizer: 第29回被服衛生学部会夏期セミナー
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-27
• [Presentation] 高齢者の暑熱負荷時の皮膚血管収縮反応性 (2010)
  • Author(s): 芝崎学, 井上芳光, 久保博子, 磯田憲生
  • Organizer: 日本家政学会
  • Place of Presentation: 広島
  • Year and Date: 2010-05-30
• [Presentation] Attenuated increases insweat rate but not skin blood flow to increasing doses of methacholine in aged skin. (2010)
  • Author(s): Shibasaki M, Inoue Y, Crandall CG.
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim
  • Year and Date: 2010-04-28
• [Presentation] Attenuated increases in sweat rate but not skin blood flow to increasing doses of methacholine in aged skin (2010)
  • Author(s): Shibasaki M, Inoue Y, Crandall CG
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim
  • Year and Date: 2010-04-28
• [Presentation] 運動時の発汗反応-皮内マイクロダイアリシスと発汗に関する研究への応用- (2009)
  • Author(s): 芝崎学
  • Organizer: 日本発汗学会教育講演
  • Place of Presentation: 博多
  • Year and Date: 2009-09-01
• [Book] 体温II (2010)
  • Author(s): 井上芳光・近藤徳彦編
  • Publisher: (有)ナップ
• [Book] 運動生理学のニューエビデンス (2010)
  • Author(s): 宮村実晴編
  • Publisher: 真興交易(株)医書出版部
• [Book] カラダの百科事典 (2009)
  • Author(s): 佐藤方彦編
  • Publisher: 丸善(株)
• [Remarks] ホームページ等
  • URL: http://www.nara-wu.ac.jp/life/health/shibasaki/index.html