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The effect of stress on ovarian function via activation of hypothalamic-pituitary hormones and sympathetic nerves.

Research Project

Project/Area Number 21790228
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionUniversity of Human Arts and Sciences

Principal Investigator

KAGITANI Fusako  University of Human Arts and Sciences, 人間科学部, 講師 (50291133)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords卵巣 / 自律神経 / エストロゲン / ストレス / 視床下部-下垂体系
Research Abstract

The present experiments examined the effects of stress stimulation on the estradiol concentration in peripheral blood plasma. Using anesthetized rats, application of noxious stimulation to the hind paw for five minutes, and of electrical stimulation, with an supramaximal intensity, directly to the ovarian sympathetic nerve for five minutes, both resulted in no change in the estradiol concentration in peripheral blood plasma. On the other hand, by the same stimulations, the secretion rate of ovarian estradiol was reduced by approximately 30% and by approximately 50%, respectively. These results showed that reduction of the secretion rate of ovarian estradiol by short-term stress stimulation is not reflected in the peripheral blood.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (22 results)

All 2011 2010 2009

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (12 results)

  • [Journal Article] The role of alpha adrenoceptors in the vascular and estradiol secretory responses to stimulation of the superior ovarian nerve.2011

    • Author(s)
      Kagitani, F., Uchida, S., Hotta, H
    • Journal Title

      Journal of Physiological Science 62

      Pages: 247-251

    • NAID

      10029050239

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Control of cerebral cortical blood flow by stimulation of basal forebrain cholinergic areas in mice.2011

    • Author(s)
      Hotta, H., Uchida, S., Kagitani, F., Maruyama, N.
    • Journal Title

      Journal of Physiological Science 61

      Pages: 201-209

    • NAID

      10029050056

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of alpha adrenoceptors in the vascular and estradiol secretory responses to stimulation of the superior ovarian nerve.2011

    • Author(s)
      Kagitani F., Uchida, S., Hotta, H
    • Journal Title

      Journal of Physiological Sciences

      Volume: 61 Pages: 247-251

    • NAID

      10029050239

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sympatho-inhibitory response of the heart as a result of short-term acupuncture-like stimulation of the rat hindlimb is not augmented when sympathetic tone is high as a result of hypercapnia.2010

    • Author(s)
      Uchida, S., Kagitani, F., Watanabe, N., Hotta, H.
    • Journal Title

      Journal of Physiological Science 60

      Pages: 221-225

    • NAID

      10027711902

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Afferent nerve fibers and acupuncture.2010

    • Author(s)
      Kagitani, F., Uchida, S., Hotta, H.
    • Journal Title

      Auton Neurosci 157

      Pages: 2-8

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neural mechanisms of reflex inhibition of heart rate elicited by acupuncture-like stimulation in anesthetized rats.2010

    • Author(s)
      Uchida, S., Kagitani, F., Hotta, H.
    • Journal Title

      Auton.Neurosci 157

      Pages: 18-23

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Afferent nerve fibers and acupuneture.2010

    • Author(s)
      Kagitani F., Uchida S., Hotta H.
    • Journal Title

      Autonomic Neuroscience : basic & clinical

      Volume: 157 Pages: 2-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Afforent nerve fibers and acupuncture.2010

    • Author(s)
      Kgagitani F., Uchida S., Hotta H.
    • Journal Title

      Autonomic Neuroscience : basic & clinical (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sympatho-inhibitory response of the heart as a result of short-term acupuncture-like stimulation of the rat hindlimb is not augmented when sympathetic tone is high as a result of hypercapnia.2010

    • Author(s)
      Uchida S., Kagitani F., Watanabe N., Hotta H.
    • Journal Title

      The journal of physiological sciences 60

      Pages: 221-225

    • NAID

      10027711902

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basal forebrain stimulation induces NGF secretion in ipsilateral parietal cortex via nicotinic receptor activation in adult, but not aged rats.2009

    • Author(s)
      Hotta, H., Kagitani, F., Kondo, M., Uchida, S.
    • Journal Title

      Neurosci Res 63

      Pages: 122-128

    • NAID

      10027499751

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] Effect of age on sympathetic regulation of ovarian estradiol secretion in rats.2011

    • Author(s)
      鍵谷方子, 内田さえ, 堀田晴美
    • Organizer
      第88回日本生理学会大会(開催中止のため紙面発表のみ)
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Ovarian estradiol secretion is regulated by autonomic nerves via activation of a2-adrenoceptors.2010

    • Author(s)
      鍵谷方子, 内田さえ, 堀田晴美
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡
    • Related Report
      2010 Final Research Report
  • [Presentation] 上卵巣神経刺激による卵巣血流および卵巣エストラジオール分泌反応におけるαアドレナリン受容体の役割2010

    • Author(s)
      鍵谷方子, 内田さえ, 堀田晴美
    • Organizer
      第63回日本自律神経学会総会発表
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Ovarian estradiol secretion is regulated by autonomic nerves via activation of α2-adrenoceptors.2010

    • Author(s)
      Kagitani F., Uchida, S., Hotta, H
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] 上卵巣神経刺激による卵巣血管および卵巣エストラジオール分泌反応におけるαアドレナリン受容体の役割2010

    • Author(s)
      鍵谷方子, 内田さえ, 堀田晴美
    • Organizer
      第63回日本自律神経学会総会
    • Place of Presentation
      横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] Regulation of the ovarian estradiol secretion rate by superior ovarian nerve in rats.2009

    • Author(s)
      Kagitani F., Uchida, S., Hotta, H.
    • Organizer
      British Society for Neuroendocrinology.
    • Place of Presentation
      Edinburgh.
    • Related Report
      2010 Final Research Report
  • [Presentation] The ovarian estradiol secretion rate is regulated by superior ovarian nerve in rats.2009

    • Author(s)
      Kagitani F., Uchida S., Hotta H.
    • Organizer
      36th International Congress of Physiological Sciences.
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] 卵巣支配自律神経の刺激がラット卵巣からのエストラジオール分泌に及ぼす影響2009

    • Author(s)
      鍵谷方子, 内田さえ, 堀田晴美
    • Organizer
      第32回日本基礎老化学会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] 卵巣支配自律神経の刺激がラット卵巣からのエストラジオール分泌に及ぼす影響2009

    • Author(s)
      鍵谷方子, 内田さえ, 堀田晴美
    • Organizer
      日本基礎老化学会第32回大会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] Regulation of the ovarian estradiol secretion rate by superior ovarian nerve in rats.2009

    • Author(s)
      Kagitani F., Uchida, S., Hotta, H
    • Organizer
      British Society for Neuroendocrinology
    • Place of Presentation
      Edinburgh
    • Related Report
      2009 Annual Research Report
  • [Presentation] The ovarian estradiol secretion rate is regulated by superior ovarian nerve ln rats.2009

    • Author(s)
      Kagitani F., Uchida S., Hotta H.
    • Organizer
      36^<th> International Congress of Physiological Sciences
    • Place of Presentation
      京都(国立京都国際会館)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 卵巣自律神経の加齢変化2009

    • Author(s)
      内田さえ, 鍵谷方子, 花田智子, 堀田晴美
    • Organizer
      第62回日本自律神経学会総会
    • Place of Presentation
      和歌山
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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