Mechanism of remodeling and functional compensation after stroke in intact hemisphere
Project/Area Number |
21790233
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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Research Institution | Gunma University |
Principal Investigator |
TAKATSURU Yusuke Gunma University, 大学院・医学系研究科, 助教 (30446265)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 2光子顕微鏡 / 脳梗塞 / In vivo imaging / In vivo microdialysis / In vivo電気生理記録 / 体性感覚 / 局所脳梗塞モデル / 2光子励起レーザー顕微鏡 / Thy1-EYFP(H-line)マウス |
Research Abstract |
Remodeling and/or synapse plasticity is increased at 1^<st> week after stroke in intact hemisphere. In contrast, recovery of general behavior is delay compared with those in simple somatosensory function. During the remodeling, glutamine, glysine and dopamine seems to be play an important role. Application of haloperidol at 2-4 days after stroke prolongs the recovery.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Neuronal circuit remodeling in the contralateral cortical hemisphere during functional recovery from cerebral infarction.2009
Author(s)
Takatsuru, Y., Fukumoto, D., Yoshitomo, M., Nemoto, T., Tsukada, H., Nabekura, J.
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Journal Title
J.Neurosci. 29(32)
Pages: 10081-10086
Related Report
Peer Reviewed
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[Presentation] Contribution ofcontralateral hemisphere on functional recovery from focal infarction in somatosensory cortex.2010
Author(s)
Takatsuru, Y., Fukumoto, D., Yoshitomo, M., Nemoto, T., Tsukada, H., Koibuchi, N., Nabekura, J.
Organizer
7th FENS
Place of Presentation
Nederland, Amsterdam
Year and Date
2010-07-06
Related Report
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[Presentation] Contribution of contralateral hemisphere on functional recovery from focal infarction in somatosensory cortex.2010
Author(s)
Takatsuru, Y., Fukumoto, D., Yoshitomo, M., Nemoto, T., Tsukada, H., Koibuchi, N.Nabekura, J.
Organizer
7^<th> FENS
Place of Presentation
アムステルダム(オランダ)
Year and Date
2010-07-06
Related Report
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[Presentation] The functional remodeling of contralateral hemisphere during the recovery from the focal infarction in somatosensory cortex.2009
Author(s)
Takatsuru, Y., Fukumoto, D., Yoshitomo, M., Nemoto, T., Tsukada, H., Nabekura, J.
Organizer
IUPS2009
Place of Presentation
京都
Year and Date
2009-07-30
Related Report
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