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Neural mechanisms underlying the sleep dependent working memory capacity improvement

Research Project

Project/Area Number 21790235
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

KURIYAMA Kenichi  独立行政法人国立精神・神経医療研究センター, 精神保健研究所・成人精神保健研究部, 室長 (00415580)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords睡眠・覚醒 / 記憶 / 学習 / 神経機能画像 / 神経生理
Research Abstract

It has been well confirmed that sleep plays a crucial role in the development of skill learning. We clarified that working memory capacity, a higher cognitive function, also benefits from post-training sleep. The enhancement of working memory capacity may associate increments of cortical activity of the frontal region during sleep. While the ability to overcome sleepiness, which essentially reflects activity in the dorsolateral prefrontal cortex, may contribute to the individual difference in working memory capacity. A NMDA agonist also facilitates the enhancement of working memory capacity after training.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (61 results)

All 2012 2011 2010 2009

All Journal Article (19 results) (of which Peer Reviewed: 14 results) Presentation (36 results) Book (6 results)

  • [Journal Article] 精神活動における内因性制御の関与2012

    • Author(s)
      栗山健一
    • Journal Title

      時間生物学

      Volume: 18 Pages: 6-9

    • URL

      http://chronobiology.jp/journal/JSC2012-1-006.pdf

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 精神ストレスの遷延防止-PTSDの発症・悪化防止の為の睡眠医療-特集睡眠医療と精神医療のリンケージによる効果的な治療プログラムの提案2012

    • Author(s)
      栗山健一
    • Journal Title

      精神神経学雑誌

      Volume: 114 Pages: 136-143

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 精神ストレスの遷延防止-PTSDの発症・悪化防止の為の睡眠医療-2012

    • Author(s)
      栗山健一
    • Journal Title

      精神神経学雑誌

      Volume: 114 Pages: 136-143

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An N-methyl-D-aspartate receptor agonist facilitates sleep-independent synaptic plasticity associated with working memory capacity enhancement2011

    • Author(s)
      Kuriyama K, Honma M, Shimazaki M, Horie M, Yoshiike T, Koyama S, Kim Y.
    • Journal Title

      Scientific Reports

      Volume: 1 Issue: 1 Pages: 127-127

    • DOI

      10.1038/srep00127

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Perceptual and not physical eye contact elicits pupillary dilation2011

    • Author(s)
      Honma M, Tanaka Y, Osada Y, Kuriyama K
    • Journal Title

      Biological Psychology

      Volume: 89 Issue: 1 Pages: 112-116

    • DOI

      10.1016/j.biopsycho.2011.09.015

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] D-cycloserine facilitates procedural learning but not declarative learning in healthy humans : a randomized controlled Trial of the effect of D-cycloserine and valproic acid on overnight properties in the performance of non-emotional memory tasks2011

    • Author(s)
      Kuriyama K, Honma M, Koyama S, Kim Y
    • Journal Title

      Neurobiology of Learning & Memory

      Volume: 95 Issue: 4 Pages: 505-509

    • DOI

      10.1016/j.nlm.2011.02.017

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of sex differences and regulation of the sleep-wake cycle on aversive memory encoding2011

    • Author(s)
      Kuriyama K, Mishima K, Soshi T, Honma M, Kim Y.
    • Journal Title

      Neurosci Res

      Volume: 70(1) Issue: 1 Pages: 104-10

    • DOI

      10.1016/j.neures.2011.01.012

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 睡眠と記憶,認知機能.特集1 :睡眠研究の動向2011

    • Author(s)
      栗山健一
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 22 Pages: 151-157

    • URL

      http://www.jsbp.org/bookinfo/book22-3/

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 睡眠と記憶,認知機能2011

    • Author(s)
      栗山健一
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 22 Pages: 151-157

    • NAID

      10029785753

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] D-cycloserine Facilitates Procedural Learning but not Declarative Learning in Healthy Humans : A Randomized Controlled Trial of the Effect of D-cycloserine and Valproic Acid on Overnight Properties in the Performance of Non-emotional Memory Tasks.2011

    • Author(s)
      栗山健一、本間元康、小山さより、金吉晴
    • Journal Title

      Neurobiology Learning and Memory

      Volume: (近刊)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of sex differences and regulation of the sleep-wake cycle on aversive memory encoding.2011

    • Author(s)
      栗山健一、三島和夫、曽雌崇弘、本間元康、金吉晴
    • Journal Title

      Neuroscience Research

      Volume: (近刊)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Right prefrontal activity reflects the ability to overcome sleepiness during working memory tasks : a functional near-infrared spectroscopy study2010

    • Author(s)
      Honma M, Soshi T, Kim K, Kuriyama K
    • Journal Title

      PLoS ONE

      Volume: 5 Issue: 9 Pages: e12923-e12923

    • DOI

      10.1371/journal.pone.0012923

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 精神・神経系疾患-その病態と治療-2010

    • Author(s)
      栗山健一
    • Journal Title

      ストレス関連障害. Cefiro特集

      Volume: 12 Pages: 20-24

    • Related Report
      2011 Final Research Report
  • [Journal Article] 特集2 :睡眠と学習・記憶2010

    • Author(s)
      栗山健一
    • Journal Title

      脳21

      Volume: 13 Pages: 402-407

    • Related Report
      2011 Final Research Report
  • [Journal Article] 時間認知の心理学・生理学・時間生物学的特性と精神病理2010

    • Author(s)
      栗山健一,曽雌崇弘,藤井猛
    • Journal Title

      時間生物学

      Volume: 16 Pages: 23-30

    • URL

      http://chronobiology.jp/journal/vol16_1.pdf

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Right prefrontal activity reflects the ability to overcome sleepiness during working memory tasks : a functional near-infrared spectroscopy study.2010

    • Author(s)
      本間元康、曽雌崇弘、金吉晴、栗山健一
    • Journal Title

      PLoS ONE

      Volume: 5(9)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 睡眠と学習・記憶2010

    • Author(s)
      栗山健一
    • Journal Title

      脳21

      Volume: 13(4) Pages: 402-407

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 睡眠と学習機能2009

    • Author(s)
      栗山健一
    • Journal Title

      生体の科学

      Volume: 60 Pages: 303-309

    • Related Report
      2011 Final Research Report
  • [Journal Article] 睡眠と学習機能2009

    • Author(s)
      栗山健一
    • Journal Title

      生体の科学 60(4)

      Pages: 303-309

    • Related Report
      2009 Annual Research Report
  • [Presentation] 睡眠剥奪によるPTSD予防の可能性2012

    • Author(s)
      栗山健一
    • Organizer
      第4回日本不安障害学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2012-02-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 睡眠剥奪によるPTSD予防の可能性2012

    • Author(s)
      栗山健一
    • Organizer
      第4回日本不安障害学会学術大会
    • Place of Presentation
      早稲田大学(東京)(招待講演)
    • Year and Date
      2012-02-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 時間認知の生理的・病理的変動シンポジウム【臨床時間生物学の現状と展望】2011

    • Author(s)
      栗山健一
    • Organizer
      日本時間生物学会第18回学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-11-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 時間認知の生理的・病理的変動シンポジウム【臨床時間生物学の現状と展望】2011

    • Author(s)
      栗山健一
    • Organizer
      日本時間生物学会第18回学術大会
    • Place of Presentation
      名古屋大学(名古屋)
    • Year and Date
      2011-11-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] NMDA受容体作動薬は覚醒時間帯における作働記憶容量増大に関わる神経可塑性を促進する2011

    • Author(s)
      吉池卓也,栗山健一,本間元康,金吉晴,西川徹
    • Organizer
      日本時間生物学会第18回学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-11-24
    • Related Report
      2011 Final Research Report
  • [Presentation] NMDA受容体作動薬は覚醒時間帯における作働記憶容量増大に関わる神経可塑性を促進する2011

    • Author(s)
      吉池卓也、栗山健一、本間元康、金吉晴、西川徹
    • Organizer
      日本時間生物学会第18回学術大会
    • Place of Presentation
      名古屋大学(名古屋)
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] PTSDの形成と悪化を防止するための睡眠医療シンポジウム【睡眠医学と精神医療のリンケージによる効果的な治療プログラムの提案】2011

    • Author(s)
      栗山健一
    • Organizer
      第107回日本精神神経学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-26
    • Related Report
      2011 Final Research Report
  • [Presentation] PTSDの形成と悪化を防止するための睡眠医療シンポジウム【睡眠医学と精神医療のリンケージによる効果的な治療プログラムの提案】2011

    • Author(s)
      栗山健一
    • Organizer
      第107回日本精神神経学会学術総会
    • Place of Presentation
      ホテル日航東京(東京)(招待講演)
    • Year and Date
      2011-10-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] NMDA receptor agonist facilitates sleep-independent synaptic plasticity associated with enhancement of working memory capacity2011

    • Author(s)
      Yoshiike T, Kuriyama K, Honma M, Shimazaki M, Kim Y, Nishikawa T
    • Organizer
      Worldsleep2011
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-10-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Sleep extinguishes false perception acquired by learning of visual-tactile integration2011

    • Author(s)
      Honma M, Yoshiike T, Shimazaki M, Koyama S, Kimura M, Kim Y, Kuriyama K
    • Organizer
      Worldsleep2011
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-10-19
    • Related Report
      2011 Final Research Report
  • [Presentation] NMDA receptor agonist facilitates sleep-independent synaptic plasticity associated with enhancement of working memory capacity2011

    • Author(s)
      吉池卓也、栗山健一、本間元康、島崎みゆき、金吉晴、西川徹
    • Organizer
      Worldsleep2011
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2011-10-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Sleep extinguishes false perception acquired by learning of visual-tactile integration2011

    • Author(s)
      本間元康、吉池卓也、島崎みゆき、小山さより、木村美貴子、金吉晴、栗山健一
    • Organizer
      Worldsleep2011
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2011-10-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 大規模自然災害被災者への睡眠医療シンポジウム【災害医療における睡眠問題】2011

    • Author(s)
      栗山健一
    • Organizer
      日本睡眠学会第36回定期学術集会
    • Place of Presentation
      京都
    • Year and Date
      2011-10-15
    • Related Report
      2011 Final Research Report
  • [Presentation] 大規模自然災害被災者への睡眠医療シンポジウム【災害医療における睡眠問題】2011

    • Author(s)
      栗山健一
    • Organizer
      日本睡眠学会第36回定期学術集会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2011-10-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 睡眠中の脳活動が手続き学習に与える影響2011

    • Author(s)
      栗山健一
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 睡眠中の脳活動が手続き学習に与える影響2011

    • Author(s)
      栗山健一
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京電機大学神田キャンパス(東京)(招待講演)
    • Year and Date
      2011-04-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 習慣的睡眠時刻前後の恐怖記憶特性における性差2010

    • Author(s)
      栗山健一,本間元康,三島和夫,金吉晴
    • Organizer
      第17回日本時間生物学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 反応抑制学習促進の時間生物学的特性2010

    • Author(s)
      本間元康,島崎みゆき,小山さより,金吉晴,栗山健一
    • Organizer
      第17回日本時間生物学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 習慣的睡眠時刻前後の恐怖記憶特性における性差2010

    • Author(s)
      栗山健一
    • Organizer
      第17回日本時間生物学会学術大会
    • Place of Presentation
      早稲田大学井深記念講堂(東京)
    • Year and Date
      2010-11-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 反応抑制学習促進の時間生物学的特性2010

    • Author(s)
      本間元康、島崎みゆき、小山さより、金吉晴、栗山健一
    • Organizer
      第17回日本時間生物学会学術大会
    • Place of Presentation
      早稲田大学井深記念講堂(東京)
    • Year and Date
      2010-11-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 睡眠と記憶・認知機能2010

    • Author(s)
      栗山健一
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      小倉
    • Year and Date
      2010-10-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 睡眠と記憶・認知機能2010

    • Author(s)
      栗山健一
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      リーガロイヤルホテル(小倉)
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 右側背外側前頭前皮質活動は認知課題遂行中の自己覚醒能力を反映する:機能的近赤外分光法を用いて2010

    • Author(s)
      本間元康,曽雌崇弘,金吉晴,栗山健一
    • Organizer
      日本睡眠学会第35回定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-07-02
    • Related Report
      2011 Final Research Report
  • [Presentation] 睡眠中と覚醒中の学習効果の質的差異-睡眠中の神経可塑性が学習に与える影響-2010

    • Author(s)
      栗山健一
    • Organizer
      日本睡眠学会第35回定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-07-01
    • Related Report
      2011 Final Research Report
  • [Presentation] 睡眠中と覚醒中の学習効果の質的差異-睡眠中の神経可塑性が学習に与える影響-2010

    • Author(s)
      栗山健一
    • Organizer
      第35回日本睡眠学会学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 右側背外側前頭前皮質活動は認知課題遂行中の自己覚醒能力を反映する:機能的近赤外分光法を用いて2010

    • Author(s)
      本間元康、曽雌崇弘、金吉晴、栗山健一
    • Organizer
      第35回日本睡眠学会学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 睡眠剥奪による短時間知覚の変動と前頭前野の血流動態変動の関連2009

    • Author(s)
      曽雌崇弘,栗山健一,有竹清夏,榎本みのり,肥田晶子,田村美由紀,金吉晴,三島和夫
    • Organizer
      第12回光脳機能イメージング研究会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-05
    • Related Report
      2011 Final Research Report
  • [Presentation] The influence of arousal and affective factors on human time perception : an fMRI study2009

    • Author(s)
      Fujii T, Kuriyama K, Soshi T, Hirota Y, Kim Y
    • Organizer
      The 6th Congress of Asian Sleep Research Society
    • Place of Presentation
      Osaka
    • Year and Date
      2009-10-27
    • Related Report
      2011 Final Research Report
  • [Presentation] The influence of sleep on learning Go/No-go task2009

    • Author(s)
      Hirota Y, Kuriyama K, Soshi T, Fujii T, Nomura S, Kim Y
    • Organizer
      The 6th Congress of Asian Sleep Research Society
    • Place of Presentation
      Osaka
    • Year and Date
      2009-10-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Sleep contributes to improvement in frontal function via growth in working memory capacity2009

    • Author(s)
      Kuriyama K
    • Organizer
      Symposium "Effects of Sleep on Memory and Cognition" The 6th Congress of Asian Sleep Research Society
    • Place of Presentation
      Osaka
    • Year and Date
      2009-10-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Prefrontal vulnerability to sleep deprivation influences short time perception change2009

    • Author(s)
      Soshi T, Kuriyama K, Aritake S, Enomoto M, Hida A, Tamura M, Kim Y, Mishima K
    • Organizer
      The 6th Congress of Asian Sleep Research Society
    • Place of Presentation
      Osaka
    • Year and Date
      2009-10-26
    • Related Report
      2011 Final Research Report
  • [Presentation] The influence of sleep on learning Go/No-go task.2009

    • Author(s)
      廣田優
    • Organizer
      第34回日本睡眠学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Sleep Accelerates the Improvement in Working Memory Performance.2009

    • Author(s)
      栗山健一
    • Organizer
      第34回日本睡眠学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Sleep contributes to improvement in frontal function via growth in working memory capacity.2009

    • Author(s)
      栗山健一
    • Organizer
      Asian Society of Sleep Research
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Late-evening exposure of fear episode accentuates the recognition gap between fear and neutral with sleep-dependent memory consolidation2009

    • Author(s)
      Kuriyama K, Soshi T, Kim Y
    • Organizer
      International symposium on biological rhythm
    • Place of Presentation
      Hokkaido
    • Year and Date
      2009-09-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Diurnal variation in human short time perception after sleep deprivation is correlated with the alteration of the prefrontal activation2009

    • Author(s)
      Soshi T, Kuriyama K, Aritake S, Enomoto M, Hida A, Tamura M, Kim Y, Mishima K
    • Organizer
      International symposium on biological rhythm
    • Place of Presentation
      Hokkaido
    • Year and Date
      2009-09-11
    • Related Report
      2011 Final Research Report
  • [Book] Infrared Spectroscopy-Life and Biomedical Sciences2012

    • Author(s)
      Kuriyama K, Honma M
    • Publisher
      In-Tech
    • Related Report
      2011 Final Research Report
  • [Book] Infrared Spectroscopy-Life and Biomedical Sciences2012

    • Author(s)
      栗山健一、本間元康
    • Total Pages
      368
    • Publisher
      In-Tech. Croatia
    • Related Report
      2011 Annual Research Report
  • [Book] 眠気の科学-そのメカニズムと対応-2011

    • Author(s)
      栗山健一
    • Publisher
      朝倉書店
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Book] 特集「眠れない」を解決する2011

    • Author(s)
      栗山健一
    • Publisher
      南山堂
    • Related Report
      2011 Final Research Report
  • [Book] 専門医のための精神科臨床リュミエール8精神疾患における睡眠障害の対応と治療編2009

    • Author(s)
      栗山健一
    • Publisher
      中山書店
    • Related Report
      2011 Final Research Report
  • [Book] 睡眠学2009

    • Author(s)
      栗山健一,内山真
    • Publisher
      朝倉書店
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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