Effect of running wheel on methamphetamine abuse in mice : a possible pharmacotherapy for drug abuse by environmental enrichment

• Project/Area Number: 21790254
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General pharmacology
• Research Institution: Hyogo College of Medicine
• Principal Investigator: KITANAKA Nobue Hyogo College of Medicine, 医学部, 講師 (30340954)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 薬物治療 / トキシコロジー / メタンフェタミン / 豊かな環境 / 依存治療 / 回転皿 / 孤独 / 不安行動 / ADHD / 覚せい剤 / 摂食行動 / 自発運動量 / 飲水行動 / ストレス

Research Abstract

We investigated whether environmental enrichment (i.e. exposure to a running wheel) affected methamphetamine (METH) effects, such as hyperlocomotion and abuse, in mice. Gradually increasing running wheel activity was observed over three consecutive days after exposure to a running wheel with no effects on their food or water intakes. Exposure to the running wheel did not affect METH-induced hyperlocomotion or development of abuse, but the exposure accelerated the extinction of METH abuse.

Research Products

• [Journal Article] Withdrawal from fixed-dose injection of methamphetamine decreases cerebral levels of 3-methoxy-4-hydroxyphenylglycol and induces the expression of anxiety-related behavior in mice. (2010)
  • Author(s): Kitanaka, N., Kitanaka, J., Tatsuta, T., Tanaka, K., Watabe, K., Nishiyama, N., Morita, Y., Takemura, M.
  • Journal Title: Neurochem. Res. 35(5) Pages: 749-760
  • Peer Reviewed
• [Journal Article] Low-dose pretreatment with clorgyline decreases the levels of 3-methoxy-4-hydroxyphenylglycol in the striatum and nucleus accumbens and attenuates methamphetamine-induced conditioned place preference in rats. (2010)
  • Author(s): Kitanaka, N., Kitanaka, J., Watabe, K., Takemura M.
  • Journal Title: Neuroscience 165(4) Pages: 1370-1376
  • Peer Reviewed
• [Journal Article] Pretreatment with L-histidine produces a shift from methamphetamine-induced stereotypical biting to persistent locomotion in mice (2010)
  • Author(s): Kitanaka J., Kitanaka N., Tatsuta T., Miyoshi A., Koumoto A., Tanaka K., Nishiyama N., Morita Y., Takemura M.
  • Journal Title: Pharmacol. Biochem. Behav. 94(3) Pages: 464-470
  • Peer Reviewed
• [Journal Article] Withdrawal from fixed-dose injection of methamphetamine decreases cerebral levels of 3-methoxy-4-hydroxyphenylglycol and induces the expression of anxiety-related behavior in mice (2010)
  • Author(s): Nobue Kitanaka, et al.
  • Journal Title: Neurochemical Research Volume: 35 Pages: 749-760
  • Peer Reviewed
• [Journal Article] Low-dose pretreatment with clorgyline decreases the levels of 3-methoxy-4-hydroxyphenylglycol in the striatum and nucleus accumbens and attenuates methamphetamine-induced conditioned place preference in rats (2010)
  • Author(s): Nobue Kitanaka et al.
  • Journal Title: Neuroscience 165 Pages: 1370-1376
  • Peer Reviewed
• [Journal Article] Pretreatment with L-histidine produces a shift front methamphetamine-induced stereotypical biting to persistent locomotion in mice (2010)
  • Author(s): Junichi Kitanaka, Nobue Kitanaka, et al.
  • Journal Title: Pharmacology, Biochemistry and Behavior 94 Pages: 464-470
  • Peer Reviewed
• [Journal Article] Histamine H_3 receptor agonists decrease hypothalamic histamine levels and increase stereotypical biting in mice challenged with methamphetamine.
  • Author(s): Kitanaka, J., Kitanaka, N., Hall, F.S., Uhl, G.R., Tatsuta, T., Morita, Y., Tanaka, K., Nishiyama, N., Takemura, M.
  • Journal Title: Neurochem. Res. In press
  • Peer Reviewed
• [Journal Article] Histamine H_3 receptor agonists decrease hypothalamic histamine levels and increase stereotypical biting in mice challenged with methamphetamine
  • Author(s): Junichi Kitanaka, Nobue Kitanaka, et al.
  • Journal Title: Neurochemical Research Volume: (In press)
  • Peer Reviewed
• [Presentation] 回転皿の経験が覚せい剤誘導場所嗜好性に及ぼす影響 (2011)
  • Author(s): 北中順惠, 北中純一, 渡部要, 田中康一, 立田知大, 守田嘉男, 西山信好, 竹村基彦
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 横浜
• [Presentation] 視床下部ヒスタミン含量変化と覚せい剤誘発常同噛み行動の発現頻度との関連性 (2011)
  • Author(s): 北中純一, 北中順惠, F.Scott Hall, George R.Uhl, 田中康一, 立田知大, 守田嘉男, 西山信好, 竹村基彦
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 横浜
• [Presentation] マウスにおける覚せい剤報酬効果、自発運動量亢進、および常同行為に対するイソリキリチゲニン(甘草フラボノイド)の効果 (2011)
  • Author(s): 北中純一, 北中順惠, 岡本正幸, 南弘樹, 田中康一, 立田知大, 守田嘉男, 西山信好, 竹村基彦
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 横浜
• [Presentation] 回転皿の経験が覚せい剤誘導場所嗜好性に及ぼす影響 (2011)
  • Author(s): 北中順惠, 他
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 横浜(東日本大震災のためにJournal of Pharmacological Sciences誌上開催)
• [Presentation] マウスにおける覚せい剤報酬効果、自発運動量亢進、および常同行為に対するイソリキリチゲニン(甘草フラボノイド)の効果 (2011)
  • Author(s): 北中純一、北中順惠, 他
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 横浜(東日本大震災のためにJournal of Pharmacological Sciences誌上開催)
• [Presentation] 視床下部ヒスタミン含量変化と覚せい剤誘発常同噛み行動の発現頻度との関連性 (2011)
  • Author(s): 北中純一, 他
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 横浜(東日本大震災のためにJournal of Pharmacological Sciences誌上開催)
• [Presentation] マウスにおける豊かな環境と覚せい剤誘発行動との関連 (2010)
  • Author(s): 北中順惠
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-03-17
• [Presentation] マウスにおける覚せい剤誘発常同噛み行動の調節にヒスタミン神経系が関与する (2010)
  • Author(s): 北中純一, 北中順惠, 河本あてな、三好晶雄、田中康一, 西山信好, 立田知大, 守田嘉男, 竹村基彦
  • Organizer: 第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] マウスにおける覚せい剤処置後の行動および脳内モノアミン含量に対する回転皿の影響 (2010)
  • Author(s): 北中順惠, 北中純一, 渡部要、田中康一, 立田知大, 西山信好, 守田嘉男, 竹村基彦
  • Organizer: 第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] マウスにおける豊かな環境と覚せい剤誘発行動との関連 (2010)
  • Author(s): 北中順惠, 北中純一, 渡部要, 立田知大, 田中康一, 西山信好, 守田嘉男, 竹村基彦
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
• [Book] Sequential expression of impaired psychomotor activities in rodents during amphetamine withdrawal.(Editor, Davies, RS.ed.)(In : Chapter 4.Handbook of Neuropsychiatry Research)(New York) (2010)
  • Author(s): Kitanaka, J., Kitanaka, N., Takemura, M.
  • Publisher: Nova Science Publishers, Inc.
• [Book] Methamphetamines : Abuse, Health Effects and Treatment Options
  • Author(s): Nobue Kitanaka, et al.
  • Publisher: Nova Science Publishers, Inc.(New York)(In press)