Role of TRB family in liver disease

Research Project

Project/Area Number	21790263
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	General medical chemistry
Research Institution	The University of Tokyo
Principal Investigator	SAIJOU Eiko 東京大学, 分子細胞生物学研究所, 技術職 (60376647)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000) Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	細胞医化学 / Tribbles / 肝臓 / 発生 / 肝疾患 / 繊維化 / ユビキチン化
Research Abstract	TRB family member TRB1 was expressed in hepatoblast fraction inE14 fetal liver of mouse. Overexpression of TRB1 induced suppression of hepatocytedifferentiation marker TAT. In contrast, hepatocyte differentiation marker expression wasincreased in fetal liver of TRB1 deficient mouse. Luciferase assay revealed that TRB1inhibits C/EBPα transcriptional activity in a dose dependent manner.

Report

(3 results)