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Roles of Dok-7 and MuSK in neuromuscular synaptogenesis

Research Project

Project/Area Number 21790266
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General medical chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

TEZUKA Tohru  The University of Tokyo, 医科学研究所, 助教 (50312319)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords神経筋接合部 / シグナル伝達 / チロシンリン酸化
Research Abstract

The neuromuscular junction (NMJ) is a synapse between a motor neuron and skeletal muscle. Defects in the formation and function of the NMJ are associated with neuromuscular disorders such as congenital myasthenic syndromes and myasthenia gravis. The muscle-specific receptor tyrosine kinase MuSK and its cytoplasmic activator Dok-7 are essential for the formation of the NMJ. To understand the molecular mechanism underlying Dok-7-mediated activation of MuSK and intracellular signaling evoked by activation of MuSK, we carried out proteomic studies. We identified proteins that bound to MuSK and Dok-7, and those that were phosphorylated upon activation of MuSK in cultured myotubes. Roles of these proteins in the formation and function of the NMJ are under investigation.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (16 results)

All 2011 2010 2009 Other

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (4 results) Book (2 results) Remarks (4 results)

  • [Journal Article] NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala.2010

    • Author(s)
      Delawary M, Tezuka T, Kiyama Y, Yokoyama K, Inoue T, Hattori S, Hashimoto R, Umemori H, Manabe T, Yamamoto T, Nakazawa T.
    • Journal Title

      Mol Brain. 3

      Pages: 37-37

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala.2010

    • Author(s)
      Delawary M.
    • Journal Title

      Molecular Brain

      Volume: 3:37

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour.2009

    • Author(s)
      Taniguchi S, Nakazawa T, Tanimura A, Kiyama Y, Tezuka T, Watabe AM, Katayama N, Yokoyama K, Inoue T, Izumi-Nakaseko H, Kakuta S, Sudo K, Iwakura Y, Umemori H, Inoue T, Murphy NP, Hashimoto K, Kano M, Manabe T, Yamamoto T.
    • Journal Title

      EMBO J. 28(23)

      Pages: 3717-3729

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The roles of Dok family adapters in immunoreceptor signaling.2009

    • Author(s)
      Mashima R, Hishida Y, Tezuka T, Yamanashi Y.
    • Journal Title

      Immunol Rev. 232(1)

      Pages: 273-285

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The roles of Dok family adapters in immunoreceptor signaling2009

    • Author(s)
      Mashima R
    • Journal Title

      Immunological Review 232

      Pages: 273-285

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour2009

    • Author(s)
      Taniguchi S
    • Journal Title

      EMBO Journal 28

      Pages: 3717-29

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Involvement of NMDAR2A tyrosine phosphorylation in depression-related behavior.2009

    • Author(s)
      中澤敬信、谷口幸子、谷村あさみ、城山優治、手塚徹、狩野方伸、真鍋俊也、山本雅
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Involvement of NMDAR2A tyrosine phosphorylation in depression-related behavior2009

    • Author(s)
      中澤敬信
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] The Novel NYAP phosphoprotein family couples activation of phosphoinositide 3-kinase (PI3K) p85 with the cytoskeletal WAVE signaling pathway in the brain.2009

    • Author(s)
      横山一剛、手塚徹、小谷政晴、中澤敬信、星名直祐、井上毅、霜田靖、角田茂、須藤カツ子、渡邉和忠、岩倉洋一郎、山本雅
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Related Report
      2010 Final Research Report
  • [Presentation] The Novel NYAP phosphoprotoin family couples activation of phosphoinositide 3-kinase(PI3K)p85 with the cytoskeletal WAVE signaling pathway in the brain2009

    • Author(s)
      横山一剛
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Book] 生体の科学(先天性筋無力症の分子基盤、Vol.62 No.2)2011

    • Author(s)
      手塚徹、山梨裕司
    • Publisher
      医学書院
    • Related Report
      2010 Final Research Report
  • [Book] 生体の科学Vol.62 No.22011

    • Author(s)
      手塚徹
    • Publisher
      医学書院
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Remarks] 研究代表者が所属する研究室のホームページ

    • URL

      http://www.ims.u-tokyo.ac.jp/genetics/html/home.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.ims.u-tokyo.ac.jp/genetics/html/home.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.ims.u-tokyo.ac.jp/genetics/html/home.html

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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