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Studies on the roles of Periplakin in liver

Research Project

Project/Area Number 21790272
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General medical chemistry
Research InstitutionKyoto University

Principal Investigator

ITO Shinji  京都大学, 医学研究科, 助教 (50362512)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords肝臓 / 遺伝子発現 / 恒常性維持 / Periplakin / 胆汁鬱滞 / FXR / 炎症 / 胆汁酸 / 遺伝子発現制御
Research Abstract

Periplakin is one of the plakin family of cytokinker proteins whose physiological roles in vivo is not fully elucidated. We have revealed that periplakin massively accumulates in hepatocytes following cholestatic injury. In addition, periplakin-null mice exhibited difference in the expression of genes related to hepatic homeostasis. Therefore, periplakin is likely involved in keeping hepatic homeostasis under cholestatic situations in liver.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (4 results)

All 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results)

  • [Journal Article] Relevant use of Klotho in FGF19subfamily signaling system in vivo2010

    • Author(s)
      Ken-ichi Tomiyama, Ryota Maeda, Itaru Urakawa, Yuji Yamazaki, Tomohiro Tanaka, Shinji ItoKen-ichi Tomiyama, Ryota Maeda, Itaru Urakawa, Yuji Yamazaki, Tomohiro Tanaka, Shinji Ito
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 107(4) Issue: 4 Pages: 1666-1671

    • DOI

      10.1073/pnas.0913986107

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relevant use of Klotho in FGF19 subfamily signaling system in vivo2010

    • Author(s)
      Ken-ichi Tomiyama, Ryota Maeda, Itaru Urakawa, Yuji Yamazaki, Tomohiro Tanaka, Shinji Ito, Yoko Nabeshima, Tsutomu Tomita, Shinji Odori, Kiminori Hosoda, Kazuwa Nakao, Akihiro Imura, Yo-ichi Nabeshima
    • Journal Title

      Proceedings of the National Academy of Science U.S.A. 107(4)

      Pages: 1666-1671

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency Yatrik2009

    • Author(s)
      M. Shah, Tsutomu Matsubara, Shinji Ito, SunHee Yim, Frank J. Gonzalez
    • Journal Title

      Cell Metabolism

      Volume: 9(2) Pages: 152-164

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency2009

    • Author(s)
      Yatrik M.Shah, Tsutomu Matsubara, Shinji Ito, SunHee Yim, Frank J.Gonzalez
    • Journal Title

      Cell Metabolism 9(20)

      Pages: 152-164

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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