Studies on the roles of Periplakin in liver

• Project/Area Number: 21790272
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: Kyoto University
• Principal Investigator: ITO Shinji 京都大学, 医学研究科, 助教 (50362512)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 肝臓 / 遺伝子発現 / 恒常性維持 / Periplakin / 胆汁鬱滞 / FXR / 炎症 / 胆汁酸 / 遺伝子発現制御

Research Abstract

Periplakin is one of the plakin family of cytokinker proteins whose physiological roles in vivo is not fully elucidated. We have revealed that periplakin massively accumulates in hepatocytes following cholestatic injury. In addition, periplakin-null mice exhibited difference in the expression of genes related to hepatic homeostasis. Therefore, periplakin is likely involved in keeping hepatic homeostasis under cholestatic situations in liver.

Research Products

• [Journal Article] Relevant use of Klotho in FGF19subfamily signaling system in vivo (2010)
  • Author(s): Ken-ichi Tomiyama, Ryota Maeda, Itaru Urakawa, Yuji Yamazaki, Tomohiro Tanaka, Shinji ItoKen-ichi Tomiyama, Ryota Maeda, Itaru Urakawa, Yuji Yamazaki, Tomohiro Tanaka, Shinji Ito
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 107(4) Pages: 1666-1671
  • DOI: 10.1073/pnas.0913986107
  • Peer Reviewed
• [Journal Article] Relevant use of Klotho in FGF19 subfamily signaling system in vivo (2010)
  • Author(s): Ken-ichi Tomiyama, Ryota Maeda, Itaru Urakawa, Yuji Yamazaki, Tomohiro Tanaka, Shinji Ito, Yoko Nabeshima, Tsutomu Tomita, Shinji Odori, Kiminori Hosoda, Kazuwa Nakao, Akihiro Imura, Yo-ichi Nabeshima
  • Journal Title: Proceedings of the National Academy of Science U.S.A. 107(4) Pages: 1666-1671
  • Peer Reviewed
• [Journal Article] Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency Yatrik (2009)
  • Author(s): M. Shah, Tsutomu Matsubara, Shinji Ito, SunHee Yim, Frank J. Gonzalez
  • Journal Title: Cell Metabolism Volume: 9(2) Pages: 152-164
  • Peer Reviewed
• [Journal Article] Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency (2009)
  • Author(s): Yatrik M.Shah, Tsutomu Matsubara, Shinji Ito, SunHee Yim, Frank J.Gonzalez
  • Journal Title: Cell Metabolism 9(20) Pages: 152-164
  • Peer Reviewed