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Roles of phospholipase C deltal in hair shaft formation

Research Project

Project/Area Number 21790292
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General medical chemistry
Research InstitutionTokyo University of Pharmacy and Life Science

Principal Investigator

NAKAMURA Yoshikazu  Tokyo University of Pharmacy and Life Science, 生命科学部, 講師 (60366416)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords毛形成 / ホスホリパーゼC / FOXN1 / Notch
Research Abstract

A transcription factor, FOXN1 is essential for hair formation. Phospholipase C (PLC)δ1, a key molecule in the phosphoinositide signaling pathway, is essential for normal hair formation. In this study, we found that Foxn1-mediated expression of PLCδ1 is important in normal hair formation and Notchl expression.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (43 results)

All 2011 2010 2009 Other

All Journal Article (15 results) (of which Peer Reviewed: 13 results) Presentation (27 results) Book (1 results)

  • [Journal Article] Phospholipase C{delta}3 Regulates RhoA/Rho Kinase Signaling and Neurite Outgrowth.2011

    • Author(s)
      Kouchi Z., Igarashi T., Shibayama N., Inanobe S., Sakurai K., Yamaguchi H., Fukuda T., Yanagi S., Nakamura Y., Fukami K.
    • Journal Title

      J.Biol.Chem. 286

      Pages: 8459-8471

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phospholipase C is a key enzyme regulating intracellular calcium and modulating phosphoinositide balance.2010

    • Author(s)
      Fukami K., Inanobe S., Kanemaru K., Nakamura Y.
    • Journal Title

      Prog Lipid Res.(Review) 49

      Pages: 429-37

    • Related Report
      2010 Final Research Report
  • [Journal Article] Phosphatidylinositol 4,5-bisphosphate and PIP5-kinase Iα are required for invadopodia formation in human breast cancer cells.2010

    • Author(s)
      Yamaguchi H., Yoshida S., Muroi E., Kawamura M., Kouchi Z., Nakamura Y., Sakai R., Fukami K.
    • Journal Title

      Cancer Sci. 101

      Pages: 1632-8

    • NAID

      10026594611

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phospholipase C-eta2 is highly expressed in the habenula and retina.2010

    • Author(s)
      Kanemaru K., Nakahara M., Nakamura Y., Hashiguchi Y., Kouchi Z., Yamaguchi H., Oshima N., Kiyonari H., Fukami K.
    • Journal Title

      Gene Expr.Patterns. 10

      Pages: 119-126

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphatidylinositol 4,5-bisphosphate and PIP5-kinase Iα are required for invadopodia formation in human breast cancer cells.2010

    • Author(s)
      Yamaguchi, H., et al
    • Journal Title

      Cancer Sci.

      Volume: 101 Pages: 1632-38

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phospholipase Cδ3 regulates RhoA/Rho kinase signaling and neurite outgrowth.2010

    • Author(s)
      Kouchi, Z., et al
    • Journal Title

      J.Biol.Chem.

      Volume: 286 Pages: 8459-71

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phospholipase Cδ3 is a novel binding partner of Myosin VI and functions as anchoring of Myosin VI on plasma membrane.2010

    • Author(s)
      Sakurai, K., et al
    • Journal Title

      Advan.Enzyme Regul.

      Volume: (IN PRESS)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of snail in epidermal keratinocytes promotes cutaneous inflammation and hyperplasia conducive to tumor formation.2010

    • Author(s)
      Fei, D., Nakamura, Y., et al.equally contributed.
    • Journal Title

      Cancer Res.

      Volume: 70 Pages: 10080-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phospholipase C-eta2 is highly expressed in the habenula and retina.2010

    • Author(s)
      Kanemaru K, Nakahara M, Nakamura Y, Hashiguchi Y, Kouchi Z, Yamaguchi H, Oshima N, Kiyonari H, Fukami K.
    • Journal Title

      Gene Expr. Patterns. 10(2-3)

      Pages: 119-126

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of phospholipase C isozymes in organogenesis and embryonic development.2009

    • Author(s)
      Nakamura Y., Fukami K.
    • Journal Title

      Physiology(Review) 24

      Pages: 332-41

    • Related Report
      2010 Final Research Report
  • [Journal Article] Lipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cells.2009

    • Author(s)
      Yamaguchi H., Takeo Y., Yoshida S., Kouchi Z., Nakamura Y., Fukami K.
    • Journal Title

      Cancer Res. 69

      Pages: 8594-602

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of phospholipase C isozymes in organogenesis and embryonic development.2009

    • Author(s)
      Nakamura Y, Fukami K.
    • Journal Title

      Physiology 24

      Pages: 332-341

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cells.2009

    • Author(s)
      Yamaguchi H, Takeo Y, Yoshida S, Kouchi Z, Nakamura Y, Fukami K.
    • Journal Title

      Cancer Res. 69

      Pages: 8594-8602

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Snail in epidermal keratinocytes promotes cutaneous inflammation and hyperplasia conducive to tumor formation.

    • Author(s)
      Du F.(*), Nakamura Y.(*), Tan T.L., Lee P., Lee R., Yu B., Jamora C.
    • Journal Title

      Cancer Res. 70(in press)

      Pages: 10080-9

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phospholipase Cδ3 is a novel binding partner of Myosin VI and functions as anchoring of Myosin VI on plasma membrane.

    • Author(s)
      Sakurai K., Hirata M., Yamaguchi H., Nakamura Y., Fukami K.
    • Journal Title

      Advan.Enzyme Regul. in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] 表皮におけるホスホリパーゼC deltalの欠損は全身性の顆粒球増加を引き起こす2010

    • Author(s)
      中村由和、金丸佳織、深見希代子
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 表皮におけるホスホリパーゼCdelta1の欠損は全身性の顆粒球増加を引き起こす2010

    • Author(s)
      中村由和, 金丸佳織, 深見希代子
    • Organizer
      BMB2010(ワークショップ)
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] ホスホリパーゼCδ1は正常な白血球数維持に重要である2010

    • Author(s)
      金丸佳織, 中村由和, 児島亮太, 深見希代子
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] 肥満形成におけるホスホリパーゼCδ1の生理的役割2010

    • Author(s)
      鈴木睦実, 平田真之, 石井里佳, 中村由和, 深見希代子
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] ホスホリパーゼC-delta1はヌード遺伝子Foxn1下流において正常な毛の形成を制御している2010

    • Author(s)
      高橋佐織, 中村由和, 深見希代子
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] PLCδ1は正常な白血球数の維持に重要である2010

    • Author(s)
      金丸佳織、藤森亮、児島亮太、中村由和、深見希代子
    • Organizer
      第52回脂質生化学会
    • Place of Presentation
      群馬
    • Related Report
      2010 Final Research Report
  • [Presentation] ホスホリパーゼC-delta1による毛形成制御機構2010

    • Author(s)
      高橋佐織、中村由和、一戸学、深見希代子
    • Organizer
      第52回脂質生化学会
    • Place of Presentation
      群馬
    • Related Report
      2010 Final Research Report
  • [Presentation] 肥満におけるホスホリパーゼCδ1の生理機能解析2010

    • Author(s)
      鈴木睦実、平田真之、石井里佳、中村由和、深見希代子
    • Organizer
      第52回脂質生化学会
    • Place of Presentation
      群馬
    • Related Report
      2010 Final Research Report
  • [Presentation] Phospholipase C-deltal Regulates Hair Keratin Expression And Hair Shaft Formation Downstream of Foxnl.2009

    • Author(s)
      Y.Nakamura ; M.Ichinohe ; S.Takahashi ; S.Inanobe ; K.Kanemaru ; K.Fukami
    • Organizer
      The American Society for Cell Biology 49th Annual meeting
    • Place of Presentation
      Convention center, San Diego, USA
    • Year and Date
      2009-12-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] ホスホリパーゼC delta1はFoxn1下流に位置し毛の形成を制御している2009

    • Author(s)
      中村由和, 一戸学, 平田真之, 高橋佐織, 深見希代子
    • Organizer
      第82回日本生化学会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] PHYSIOLOGICAL FUNCTIONS OF BIO ACTIVE LIPID PRODUCER, PHOSPHOLIPASE C-DELTA1 IN SKIN2009

    • Author(s)
      Nakamura Y., Fukami K.
    • Organizer
      4^<th> INTERNATIONAL CONFERENCE ON PHOS PHOLIFASE A_2 AND LIPID MEDIATORS
    • Place of Presentation
      学術総合センター
    • Year and Date
      2009-05-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Phospholipase C-delta1 Regulates Hair Keratin Expression And Hair Shaft Formation Downstream of Foxn12009

    • Author(s)
      Nakamura, Y., Ichinohe, M., Takahashi, S., Inanobe, S., Kanemaru, K., Fukami, K.
    • Organizer
      The American Society for Cell Biology 49th Annual meeting
    • Place of Presentation
      San Diego
    • Related Report
      2010 Final Research Report
  • [Presentation] Physiological functions of phospholipase C δ1 in adipose tissue development and obesity (part1)2009

    • Author(s)
      Ishii, R., Hirata, M., Suzuki, M., Matsuoka, S., Nakamura, Y., Kouchi, Z., Yamaguchi, H., Sasaki, T., Kitamurea, T., Fukami, K.
    • Organizer
      The 6th Japan-Korea Conference on celluer signaling for young scientists
    • Place of Presentation
      Nagasaki
    • Related Report
      2010 Final Research Report
  • [Presentation] Phospholipase C δ3 is involved in neurite outgrowth of cerebral cortical neurons and Neuro2A cells2009

    • Author(s)
      Shibayama, N., Kouchi, Z., Fukuda, T., Igrashi, T., Nakamura, Y., Yamaguchi, H., Yanagi, S., Fukami, K.
    • Organizer
      The 6th Japan-Korea Conference on Cellular Signaling for Young Scientists
    • Place of Presentation
      Nagasaki
    • Related Report
      2010 Final Research Report
  • [Presentation] Lack of phospholipase C delta1 accelerates skin wound healing2009

    • Author(s)
      Inanobe, S., Nakamura, Y., Ichinohe, M., Hirata, M., Kouchi, Z., Yamaguchi, H., Fukami, K.
    • Organizer
      The 6th Japan-Korea Conference on Cellular Signaling for Young Scientists
    • Place of Presentation
      Nagasaki
    • Related Report
      2010 Final Research Report
  • [Presentation] ホスフォリパーゼCδ1は様々な生理機能に関与する2009

    • Author(s)
      深見希代子、平田真之、石井里佳、一戸学、中村由和
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸(シンポジウム)
    • Related Report
      2010 Final Research Report
  • [Presentation] ホスホリパーゼCdelta1はFoxn1下流に位置し毛の形成を制御している2009

    • Author(s)
      中村由和、一戸学、平田真之、高橋佐織、深見希代子
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] 大腸癌細胞におけるvitaminDレセプター依存的なE-cadherinの発現誘導にPIP kinase IIβが関与する2009

    • Author(s)
      河内全、小堀真平、宮崎聡一郎、中村由和、山口英樹、深見希代子
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] 白血球の機能、分化におけるホスホリパーゼδ1の機能解析2009

    • Author(s)
      金丸佳織、中村由和、河内全、山口英樹、深見希代子
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] PLCδ1による毛包形態および毛の構成ケラチン発現の制御2009

    • Author(s)
      高橋佐織、一戸学、中村由和、平田真之、河内全、山口英樹、深見希代子
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] 脂肪細胞形成におけるホスホリパーゼCδ1の生理機能解析2009

    • Author(s)
      石井里佳、平田真之、鈴木睦美、松岡翔一、中村由和、河内全、山口英樹、深見希代子
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] 創傷治癒におけるホスポリパーゼCδ1の役割2009

    • Author(s)
      稲野邊俊一、中村由和、一戸学、平田真之、河内全、山口英樹、深見希代子
    • Organizer
      第51回日本脂質生化学会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] Neuro2a細胞の神経突起伸長におけるPLCδ3の機能解析2009

    • Author(s)
      河内全、五十嵐隆公、柴山奈美、中原真道、中村由和、山口英樹、深見希代子
    • Organizer
      第51回日本脂質生化学会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] 浸潤突起形成における脂質ラフトとカベオリンの役割2009

    • Author(s)
      山口英樹、竹尾由希子、吉田周平、河内全、中村由和、深見希代子
    • Organizer
      第61回日本細胞生物学会(ワークショップ)
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] Phospholipase Cδ3はNeuro2a細胞における神経突起伸長に関与する2009

    • Author(s)
      柴山奈美、河内全、五十嵐隆公、中村由和、山口英樹、深見希代子
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] 肥満におけるホスホリパーゼCdeltalの生理機能解析2009

    • Author(s)
      平田真之、石井里佳、一戸学、中村由和、河内全、山口英樹、深見希代子
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] physiological functions of a bioactive lipid producer,phospholipase c-delta 1 in skin2009

    • Author(s)
      Nakamura, Y.
    • Organizer
      4th International Conference on Phospholipase A2 and Lipid Mediators
    • Place of Presentation
      Tokyo
    • Related Report
      2010 Final Research Report
  • [Book] 遺伝子改変マウスの表現型より示されるホスホリパーゼCの生理的役割(実験医学増刊分子から個体へと深化する脂質生物学)(28(20))

    • Author(s)
      中村由和、深見希代子
    • Publisher
      羊土社
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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