Development of a multiphase screening method for genes responsible for age-dependent neurodegenerative disorders
Project/Area Number |
21790302
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Pathological medical chemistry
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Research Institution | Juntendo University (2010-2011) Tohoku University (2009) |
Principal Investigator |
IMAI Yuzuru 順天堂大学, 大学院・医学研究科, 先任准教授 (30321730)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | パーキンソン病 / LRRK2 / PINK1 / Parkin / 神経変性疾患 / ドーパミン神経 / ショウジョウバエ / ミトコンドリア / ドパミン神経 |
Research Abstract |
PINK1 and LRRK2 are the genes responsible for early-onset and late-onset familial forms of Parkinson’s disease, respectively. I developed a new approach that combines a proteomics analysis and a Drosophila genetic screening to understand the pathogenesis of Parkinson’s disease caused by PINK1 and LRRK2 mutations. Using this approach, I successfully determined molecules that are involved in the PINK1 and LRRK2 pathology, which will contribute to understanding of pathogenesis in these diseases.
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Report
(3 results)
Research Products
(49 results)
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[Journal Article] The Loss of PGAM5 Suppresses the Mitochondrial Degeneration Caused by Inactivation of PINK1 in Drosophila2010
Author(s)
Imai, Y., Kanao, T., Sawada, T., Kobayashi, Y., Moriwaki, Y., Ishida, Y., Takeda, K., Ichijo, H., Lu, B., Takahashi, R.
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Journal Title
PLoS Genet
Volume: e1001229
Related Report
Peer Reviewed
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[Journal Article] Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila2010
Author(s)
Kanao, T., Venderova, K., Park, DS., Unterman, T., Lu, B., Imai, Y.
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Journal Title
Hum Mol Genet
Volume: 19
Pages: 3747-3758
Related Report
Peer Reviewed
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[Presentation] Nitric oxide signal modulates FoxO's activity and alters dopaminergic nueron survival and motor activity in Drosophila2010
Author(s)
Kanao, T., Sawada, T., Davies, SA., Moriwaki, Y., Takahashi, R. Imai, Y.
Organizer
第33回日本分子生物学会年会・第83回日本生化学会大会合同大会口演およびポスター
Place of Presentation
神戸
Year and Date
2010-12-08
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[Presentation] The Loss of PGAM5 Suppresses the Mitochondrial Degeneration Caused by Inactivation of PINK1 in Drosophila2010
Author(s)
Imai, Y., Kanao, T., Sawada, T., Kobayashi, Y., Moriwaki, Y., Ishida, Y., Takeda, K., Ichijo, H., Lu, B., Takahashi, R.
Organizer
第33回日本分子生物学会年会・第83回日本生化学会大会合同大会口演およびポスター
Place of Presentation
神戸
Related Report
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