The dynamic regulation of an Ig-like cell adhesion molecule, CADM1 in cell adhesion and invasion
Project/Area Number |
21790309
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Pathological medical chemistry
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Research Institution | The University of Tokyo |
Principal Investigator |
SAKURAI Mika 東京大学, 医科学研究所, 助教 (80508359)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 細胞接着 / CADM1 / 動的制御 / FRAP法 / 細胞間接着 / 細胞骨格 / FRAP / FLIP / 細胞浸潤 / ダイナミクス / シグナル伝達 |
Research Abstract |
A cell adhesion molecule, CADM1, is involved in the formation and maintenance of epithelial cell adhesion by interacting with actin-binding proteins. By analyzing the dynamic regulation of CADM1 complex using fluorescence-tagged molecules, CADM1 complex was found to be exchanged continuously in confluent cells. In contrast, in adult T-cell leukemia(ATL), CADM1 played a role in trans-endothelial migration through the formation of the protrusion at the attachment sites of ATL and endothelial cells.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Expression of a splicing variant of the CADM1 specific to small cell lung cancer2012
Author(s)
Kikuchi, S., Iwai, M., Sakurai-Yageta, M., Tsuboi, Y., Ito, T., Maruyama, T., Tsuda, H., Kanai, Y., Onizuka, M., Sato, Y., et al
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Journal Title
Cancer Sci
Volume: 103
Pages: 1051-7
Related Report
Peer Reviewed
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[Journal Article] Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma2012
Author(s)
Nagata, M., Sakurai-Yageta, M., Yamada, D., Goto, A., Ito, A., Fukuhara, H., Kume, H., Morikawa, T., Fukayama, M., Homma, Y., et al
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Journal Title
Int J Cancer
Volume: 130
Pages: 1329-37
Related Report
Peer Reviewed
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[Journal Article] Expression of a splicing variant of the CADM1 specific to small cell lung cancer2012
Author(s)
Kikuchi S, Iwai M, Sakurai-Yageta M, Tsuboi Y, Ito T, Maruyama T, Tsuda H, Kanai Y, 0nizuka M, Sato Y, Murakami Y
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Journal Title
Cancer Science
Volume: 103
Issue: 6
Pages: 1051-1057
DOI
Related Report
Peer Reviewed
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[Journal Article] Transcriptional regulation of the CADM1 gene by retinoic acid during the neural differentiation of murine embryonal carcinoma P19 cells2011
Author(s)
Ito, T., Williams-Nate, Y., Iwai, M., Tsuboi, Y., Hagiyama, M., Ito, A., Sakurai-Yageta, M. and Murakami, Y
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Journal Title
Genes Cells
Volume: 16
Pages: 791-802
Related Report
Peer Reviewed
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[Journal Article] Aberrant expression of tumor suppressors CADM1 and 4. 1B in invasive lesions of primary breast cancer2011
Author(s)
Takahashi, Y., Iwai, M., Kawai, T., Arakawa, A., Ito, T., Sakurai-Yageta, M., Ito, A., Goto, A., Saito, M., Kasumi, F., et al
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Journal Title
Breast Cancer
Volume: (In press)
Related Report
Peer Reviewed
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