| Project/Area Number |
21790312
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
NAKAMURA Takahiro Kanazawa University, がん研究所, 助教 (70414018)
|
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | HGF / Met / 組織再生 / シグナル伝達 / 細胞増殖因子 |
|---|
| Research Abstract |
To address the function of the natural isoform of the Met/HGF receptor during tissue regeneration, disease and oncogenesis, I prepared the MDCK cells that stably express the ΔJM-Met or WT-Met gene and ΔJM-Met knockin mice. As a result, I could not find the any difference between ΔJM-Met and WT-Met expressed MDCK cells in the ability of motility and morphogenesis. Δ JM-Met knockin mice were resulted in embryonic lethal.
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