• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Biomarker Analysis from Human Age-Related Macular Degeneration using Imaging Mass Spectrometry

Research Project

Project/Area Number 21790315
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

HAYASAKA Takahiro  Hamamatsu University School of Medicine, 分子イメージング先端研究センター, 特任助教 (90415927)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords網膜 / 加齢黄斑変性症 / 質量分析 / イメージング / バイオマーカー / 綱膜
Research Abstract

In this study we tried to detect biomarkers of human age-related macular degeneration (ARMD) using imaging mass spectrometry (IMS). The optimization of conventional matrices onto the surface of biological section and the application of metal core nanoparticles as a matrix enabled us to detect several lipids and fatty acids by IMS analysis. We revealed the specific biomarker from ARMD compared with normal tissue section.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (25 results)

All 2010 2009 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (12 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Imaging Mass Spectrometry with Silver Nanoparticles Reveals the Distribution of Fatty Acids in Mouse Retinal Sections2010

    • Author(s)
      Hayasaka T, Goto-Inoue N, Zaima N, Shrivas K, Kashiwagi Y, Yamamoto M, Nakamoto M, Setou M.
    • Journal Title

      21(8)

      Pages: 1446-1454

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Phospholipid Molecular Species between Terminal and Stem Villi of Human Term2010

    • Author(s)
      Kobayashi Y, Hayasaka T, Setou M, Itoh H, Kanayama N.
    • Journal Title

      Placenta 31(3)

      Pages: 245-248

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imaging Mass Spectrometry with Silver Nanoparticles Reveals the Distribution of Fatty Acids in Mouse Retinal Sections.2010

    • Author(s)
      Hayasaka T, Goto-Inoue N, Zaima N, Shrivas K, Kashiwagi Y, Yamamoto M, Nakamoto M, Seton M.
    • Journal Title

      Journal of American Society for Mass Spectrometry

      Volume: 21(8) Pages: 1446-1454

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Phospholipid Molecular Species between Terminal and Stem Villi of Human Term.2010

    • Author(s)
      Kobayashi Y^*, Hayasaka T^*, Setou M, Itoh H, Kanayama N.^*First two authors equally contributed to the study.
    • Journal Title

      Placenta 31(3)

      Pages: 245-248

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Organ-Specific Distributions of Lysophosphatidylcholine and Triacylglycerol in Mouse Embryo2009

    • Author(s)
      Hayasaka T, Goto-Inoue N, Zaima N, Kimura Y, Setou M.
    • Journal Title

      Lipids 44(9)

      Pages: 837-848

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Organ-Specific Distributions of Lysophosphatidylcholine and Triacylglycerol in Mouse Embryo.2009

    • Author(s)
      Hayasaka T, Goto-Inoue N, Zaima N, Kimura Y, Setou M.
    • Journal Title

      Lipids 44(9)

      Pages: 837-848

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of imaging mass spectrometry (IMS) dataset extractor software, IMS Convolution

    • Author(s)
      Hayasaka T, Goto-Inoue N, Ushijima M, Yao I, Yuba-Kubo A, Wakui M, Kajihara S, Matsuura M, Setou M.
    • Journal Title

      Analytical and Bioanalytical Chemistry in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of imaging mass spectrometry (IMS) dataset extractor software, IMS Convolution.

    • Author(s)
      Hayasaka T, Goto-Inoue N, Ushijima M, Yao I, Yuba-Kubo A, Wakui M, Kajihara S, Matsuura M, Setou M.
    • Journal Title

      Analytical and Bioanalytical Chemistry

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 質量顕微鏡法を用いた分子イメージング2010

    • Author(s)
      早坂孝宏
    • Organizer
      第125回質量分析学会関西談話会
    • Place of Presentation
      神戸薬科大学
    • Year and Date
      2010-09-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 質量顕微鏡を用いた分子イメージング2010

    • Author(s)
      早坂孝宏
    • Organizer
      第125回質量分析学会関西談話会
    • Place of Presentation
      神戸薬科大学
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 質量顕微鏡法へのナノ粒子の応用2010

    • Author(s)
      早坂孝宏、井上菜穂子、財満信宏、Kamlesh Shrivas、柏木行康、山本真理、中許昌美、瀬藤光利
    • Organizer
      第48回日本生物物理学会年会
    • Place of Presentation
      東北大学
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 銀ナノ粒子を用いた質量分析イメージングによる脂肪酸の可視化2010

    • Author(s)
      早坂孝宏、井上菜穂子、財満信宏、Kamlesh Shrivas、柏木行康、山本真理、中許昌美、瀬藤光利
    • Organizer
      日本油化学会第49回年会
    • Place of Presentation
      北海道大学
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] MALDI-TOF MSを用いた質量顕微鏡法2010

    • Author(s)
      早坂孝宏、瀬藤光利
    • Organizer
      マイクロビームアナリシス第141委員会第141回研究会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2010-08-30
    • Related Report
      2010 Final Research Report
  • [Presentation] MALDI-TOF MSを用いた質量顕微鏡法2010

    • Author(s)
      早坂孝宏、瀬藤光利
    • Organizer
      マイクロビームアナリシス第141委員会 第141回研究会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2010-08-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 金属ナノ粒子を用いた生体試料の質量分析イメージング2010

    • Author(s)
      早坂孝宏、瀬藤光利
    • Organizer
      第2回ナノインク懇話会
    • Place of Presentation
      大阪市立工業研究所
    • Year and Date
      2010-08-27
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 銀ナノ微粒子を用いたマウス網膜の質量分析イメージング2010

    • Author(s)
      早坂孝宏、井上菜穂子、財満信宏、Kamlesh Shrivas、柏木行康、山本真理、中許昌美、瀬藤光利
    • Organizer
      第58回質量分析総合討論会,第1回アジア・オセアニア質量分析会議
    • Place of Presentation
      つくば
    • Year and Date
      2010-06-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 銀ナノ微粒子を用いたマウス網膜の質量分析イメージング2010

    • Author(s)
      早坂孝宏、井上菜穂子、財満信宏、Kamlesh Shrivas、柏木行康、山本真理、中許昌美、瀬藤光利
    • Organizer
      第58回質量分析総合討論会,第1回アジア¥オセアニア質量分析会議
    • Place of Presentation
      つくば
    • Year and Date
      2010-06-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 分子イメージングによる形態学2010

    • Author(s)
      早坂孝宏、財満信宏、池上浩司、小西慶幸、瀬藤光利
    • Organizer
      第115回日本解剖学会総会・全国学術集会
    • Place of Presentation
      岩手医科大学
    • Year and Date
      2010-03-28
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Imaging mass spectrometry revealed the tissue-specific distributions of lysophosphatidylcholine and triacylglycerol in mouse embryonic sections2009

    • Author(s)
      Takahiro Hayasaka, Naoko Goto-Inoue, Nobuhiro Zaima, Mitsutoshi Setou
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-06-04
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] MSイメージングを用いたマウス胎児におけるLPC及びTAGの解析2009

    • Author(s)
      早坂孝宏、井上菜穂子、財満信宏、瀬藤光利
    • Organizer
      第57回質量分析総合討論会
    • Place of Presentation
      つくば
    • Year and Date
      2009-05-13
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Book] Method of Operating AXIMA-QIT as Imaging Instrument Imaging Mass Spectrometry : Protocols for Mass Microscopy Chapter 82010

    • Author(s)
      Takahiro Hayasaka
    • Total Pages
      15
    • Related Report
      2010 Final Research Report
  • [Book] Imaging Mass Spectrometry : Protocols for Mass Microscopy(Chapter 8 : Method of Operating AXIMA-QIT as Imaging Instrument)2010

    • Author(s)
      Takahiro Hayasaka
    • Total Pages
      15
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.hama-med.ac.jp/mt/setou/ja/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.hama-med.ac.jp/mt/setou/ja/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.hama-med.ac.jp/university/chair/setou/ja/list.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi