The Identification of Genes Associated with Radiation-related Thyroid Cancer by Genome Wide Association Analysis

• Project/Area Number: 21790337
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human genetics
• Research Institution: Kyoto University
• Principal Investigator: TAKAHASHI Meiko Kyoto University, 医学研究科, 助教 (20372592)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: ゲノム医科学 / GWAS / 甲状腺がん / SNP / 甲状線がん

Research Abstract

The main aim of this research is to identify the SNPs associated with the risk of radiation-related thyroid cancer. We have started genome wide association analyses of thyroid cancer patients who were aged 0-18 years and resided in the radio-contaminated regions of Belarus at the time of the Chernobyl accident, and matched Belarusian control subjects.

Research Products

• [Journal Article] The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl. (2010)
  • Author(s): Meiko Takahashi, Vladimir Saenko, Tatiana Rogounovitch, Takahisa Kawaguchi, Valentina Drozd, Hisako Takigawa-Imamura,Natallia Akulevich, Chanavee Ratanajaraya, Norisato Mitsutake, Noboru Takamura, Larisa Danilova, Maxim Lushchik, Yuri Demidchik, Simon Heath, Ryo Yamada, Mark Lathrop, Fumihiko Matsuda, Shunichi Yamashita.
  • Journal Title: Human Molecular Genetics Vol.19 Pages: 2516-2523
  • NAID: 120006984984
  • Peer Reviewed
• [Journal Article] The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl. (2010)
  • Author(s): Takahashi M, Saenko VA, et al.
  • Journal Title: Human Molecular Genetics (Epub)
  • NAID: 120006984984
  • Peer Reviewed
• [Presentation] チェルノブイリコホートの全ゲノム関連解析による放射線誘発甲状腺がん感受性遺伝子の同定 (2010)
  • Author(s): 高橋めい子
  • Organizer: 第55回大会日本人類遺伝学会
  • Place of Presentation: 大宮ソニックシティ
  • Year and Date: 2010-10-28
• [Presentation] チェルノブイリコホートの全ゲノム関連解析による放射線誘発甲状腺がん感受性遺伝子の同定 (2010)
  • Author(s): 高橋めい子
  • Organizer: 日本人類遺伝学会 第55回大会
  • Place of Presentation: 大宮ソニックシティ(さいたま市大宮区)
  • Year and Date: 2010-10-28
• [Presentation] チェルノブイリコホートのゲノムワイド解析による放射線誘発甲状腺がん感受性遺伝子の同定 (2009)
  • Author(s): 高橋めい子
  • Organizer: 第54回大会日本人類遺伝学会
  • Place of Presentation: グランドプリンスホテル高輪
  • Year and Date: 2009-09-24
• [Presentation] チェルノブイリコホートのゲノムワイド解析による放射線誘発甲状腺がん感受性遺伝子の同定 (2009)
  • Author(s): 高橋めい子
  • Organizer: 日本人類遺伝学会第54回大会
  • Place of Presentation: グランドプリンスホテル高輪(東京都)
  • Year and Date: 2009-09-24