Expression of adenosine receptor in thyroid carcinomas
Project/Area Number |
21790348
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Human pathology
|
Research Institution | University of Yamanashi |
Principal Investigator |
NAKAZAWA Tadao 山梨大学, 医学工学総合研究部, 助教 (10345704)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
Keywords | 甲状腺癌 / アデノシンレセプター / 分子病理学的解析 / アデノシン / アデノシン受容体 |
Research Abstract |
Overexpression of adenosine receptors have recently been identified in several human cancers. The purpose of this study is to examine expression of adenosine receptor and its molecular analysis in thyroid tumors. Compared with normal thyroid tissues and benign tumors(follicular adenomas), expression of adenosine receptor 1(ADRA1) was up-regulated in thyroid carcinomas. Furthermore, this observation increased tumor cell growth and invasion in vitro. These result may suggest the adenosinergic system as a potential pharmacological target in thyroid cancer therapeutics
|
Report
(4 results)
Research Products
(13 results)