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Detection of genomic instability using a level of 53BP1 nuclear focus in Atomic bomb survivors tissue

Research Project

Project/Area Number 21790357
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionNagasaki University

Principal Investigator

MIURA Shiro  Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (80513316)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords原爆被爆者 / ゲノム不安定性 / 放射線 / 53BP1 / DNA損傷応答
Research Abstract

We have examined associations with cancer in atomic bomb (A-bomb) survivor and A-bomb radiation exposure. We have estimated that the signature of radiation effect (genomic instability : GIN) remains in A-bomb survivors' cells and GIN induce carcinogenesis. This study aims to detect the existence of GIN in normal skin tissue in A-bomb surviviors. We use a protein of 53BP1 localized at the sites of DNA double strand breaks and forms discrete nuclear foci to detect GIN. The results of this study suggest GIN in normal cells of the proximal group (shorting distance group from the hypocenter) is increasing, and GIN induced radiation is associated with A-bomb survivors' carcinogenesis.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (30 results)

All 2011 2010 2009 Other

All Journal Article (11 results) (of which Peer Reviewed: 5 results) Presentation (18 results) Remarks (1 results)

  • [Journal Article] Significance of p53-binding protein 1 nuclear foci in uterine cervical lesions : Endogenous DNA double strand breaks and genomic instability during carcinogenesis.2011

    • Author(s)
      Matsuda K
    • Journal Title

      Histopathology

      Volume: (in press)(掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA damage response in aberrant crypt foci of radiation colitis as a anti-cancer barrier in early tumorigenesis.2010

    • Author(s)
      Shichijo K, Ihara M, Miura S, Kurashige T, Matsuyama M, Nakashima M, Nakayama T, Sekine I
    • Journal Title

      Gastroenterol 138(Suppl.1):S-509

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 長崎被爆者腫瘍組織バンク構築とその必要性2010

    • Author(s)
      三浦史郎, 中島正洋, 蔵重智美, 塚崎邦弘, 岩永正子, 近藤久義, 横田賢一, 三根真理子, 山下俊一, 関根一郎
    • Journal Title

      広島医学 63

      Pages: 275-277

    • Related Report
      2010 Final Research Report
  • [Journal Article] 長崎被爆者腫瘍組織バンク構築に向けた生体試料収集の経過報告2010

    • Author(s)
      三浦史郎, 蔵重智美, 塚崎邦弘, 近藤久義, 横田賢一, 三根真理子, 宮崎泰司, 関根一郎, 中島正洋
    • Journal Title

      長崎医学会雑誌 85

      Pages: 294-297

    • Related Report
      2010 Final Research Report
  • [Journal Article] 直腸炎型の潰瘍性大腸炎にクラミジア直腸炎を併発した1例2010

    • Author(s)
      亀山大介, 陳俊全, 三嶋亮介, 井上健一郎, 三浦史郎, 牧山和也
    • Journal Title

      長崎医学会雑誌 85

      Pages: 30-36

    • Related Report
      2010 Final Research Report
  • [Journal Article] DNA damage response in aberrant crypt foci of radiation colitis as a anti-cancer barrier in early tumorigenesis.2010

    • Author(s)
      Shichijo K
    • Journal Title

      Gastroenterol

      Volume: 138(Suppl.1)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 長崎被爆者腫瘍組織バンク構築とその必要性2010

    • Author(s)
      三浦史郎
    • Journal Title

      広島医学

      Volume: 63 Pages: 275-277

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 長崎原爆被爆者腫瘍組織バンク構築に向けた生体試料収集の経過報告2010

    • Author(s)
      三浦史郎
    • Journal Title

      長崎医学会雑誌

      Volume: 85 Pages: 294-297

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 直腸炎型の潰瘍性大腸炎にクラミジア直腸炎を併発した1例2010

    • Author(s)
      亀山大介
    • Journal Title

      長崎医学会雑誌

      Volume: 85 Pages: 30-36

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Differential expression of vascular endothelial growth factor (VEGF) and VEGF receptors in the sequence of hyperplastic polyp, serrated adenoma and adenocarcinoma of colorectum2009

    • Author(s)
      Taba M
    • Journal Title

      Acta Med.Nagasaki 53

      Pages: 85-88

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of p53-binding protein 1 nuclear foci in uterine cervical lesions : Endogenous DNA double strand breaks and genomic instability during carcinogenesis.

    • Author(s)
      Matsuda K, Miura S, Kurashige T, Suzuki K, Kondo H, Ihara M, Nakajima H, Masuzaki H, Nakashima M
    • Journal Title

      Histopathology in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] Induction of autophagy in rat thyroid gland after external irradiation2011

    • Author(s)
      Matsuyama M
    • Organizer
      広島大学原爆放射線医科学研究所 第1回国際シンポジウム
    • Place of Presentation
      広島
    • Year and Date
      2011-03-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Induction of autophagy in rat thyroid gland after external irradiation.2011

    • Author(s)
      Matsuyama M, Shichijo K, Kurashige T, Okaichi K, Miura S, Nakashima M
    • Organizer
      広島大学原爆放射線医科学研究所第1回国際シンポジウム
    • Place of Presentation
      広島
    • Related Report
      2010 Final Research Report
  • [Presentation] Significance of 53BP1 expression in thyroid papillary microcarcinoma : correlation analysis between BRAF mutation and nodal metastasis2010

    • Author(s)
      ムサジャノワジャンナ
    • Organizer
      第56回日本病理学会秋期特別総会
    • Place of Presentation
      北九州
    • Year and Date
      2010-11-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 長崎被爆者腫瘍組織バンク構築に向けた生体試料収集の経過報告2010

    • Author(s)
      三浦史郎, 蔵重智美, 塚崎邦弘, 近藤久義, 横田賢一, 三根真理子, 宮崎泰司, 関根一郎, 中島正洋
    • Organizer
      第51回長崎原子爆弾後障害研究会
    • Place of Presentation
      長崎
    • Year and Date
      2010-06-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 長崎原爆被爆者腫瘍組織バンク構築に向けた生体試料収集の経過報告2010

    • Author(s)
      三浦史郎
    • Organizer
      第51回長崎原子爆弾後障害研究会
    • Place of Presentation
      長崎
    • Year and Date
      2010-06-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子宮頸部腫瘍での53BP1とKi67蛍光二重免疫染色によるDNA損傷応答異常解析:高度異形成と上皮内癌の鑑別2010

    • Author(s)
      松田勝也, 三浦史郎, 蔵重智美, 鈴木啓司, 近藤久義, 増崎英明, 中島正洋
    • Organizer
      第6回広島大学・長崎大学連携研究事業カンファランス
    • Place of Presentation
      長崎
    • Year and Date
      2010-06-05
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 長崎原爆被爆者腫瘍組織バンクの構築と臨床病理学的解析~第2報~2010

    • Author(s)
      三浦史郎
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 成熟甲状腺濾胞上皮の放射線誘発細胞死耐性の分子機構2010

    • Author(s)
      松山睦美, 蔵重智美, 七條和子, 岡市協生, 平川宏, 三浦史郎, 中島正洋
    • Organizer
      第53回日本甲状腺学会学術集会
    • Place of Presentation
      長崎
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 放射線照射ラット甲状腺組織でのDNA損傷応答分子発現解析2010

    • Author(s)
      松山睦美, 蔵重智美, 七條和子, 岡市協生, 平川宏, 三浦史郎, 中島正洋
    • Organizer
      第53回日本放射線影響学会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 長崎原爆被爆者腫瘍組織バンクの構築と臨床病理学的解析-第2報2010

    • Author(s)
      三浦史郎, 中島正洋, 蔵重智美, 塚崎邦弘, 山下俊一, 関根一郎
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 子宮頸部腫瘍での53BP1とKi67蛍光二重免疫染色によるDNA損傷応答異常解析:高度異形成と上皮内癌の鑑別2010

    • Author(s)
      松田勝也, 中島正洋, 三浦史郎, 蔵重智美, 鈴木啓司, 増崎英明, 関根一郎
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 甲状腺微小乳頭癌での53BP1発現の意義:BRAF遺伝子変異とリンパ節転移との関連2010

    • Author(s)
      ムサジャノワジャンナ, 中島正洋, サイエンコウラジミール, 三浦史郎, 関根一郎
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 子宮頸部腫瘍におけるDNA損傷応答分子53BP1発現解析-癌化とゲノム不安定性の関連-2009

    • Author(s)
      松田勝也
    • Organizer
      第48回日本臨床細胞学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 第1回内視鏡生検検査の組織標本の見方2009

    • Author(s)
      三浦史郎
    • Organizer
      長崎県病理検査研修会
    • Place of Presentation
      長崎
    • Year and Date
      2009-08-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 長崎被爆者腫瘍組織バンク構築とその必要性2009

    • Author(s)
      三浦史郎
    • Organizer
      第50回原子爆弾後障害研究会
    • Place of Presentation
      広島
    • Year and Date
      2009-06-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Interleukin 11 ameliorates radiation colitis by enhamced bone marrow contribution to repair of colonic tissue in rats2009

    • Author(s)
      Shichijo K
    • Organizer
      Digestive Disease Week 2009
    • Place of Presentation
      Chicago
    • Year and Date
      2009-05-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] 大腸癌の浸潤・転移におけるAngiopoietin-like 4(ANGPTL4)蛋白の発現の検討2009

    • Author(s)
      中山敏幸
    • Organizer
      第98回日本病理学会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 長崎原爆被爆者腫瘍組織バンクの構築とその必要性2009

    • Author(s)
      三浦史郎
    • Organizer
      第98回日本病理学会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-01
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://users.tls-style.jp/nagasaki-u/pathology/

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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