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Carcinogenic pathway and prognosis of gastric cancer in young patients : genome instability and DNA methylation

Research Project

Project/Area Number 21790363
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionKitasato University

Principal Investigator

ICHINOE Masaaki  Kitasato University, 医学部, 講師 (80365163)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords胃癌 / 若年 / 予後 / 若年胃癌 / MSI / LOH
Research Abstract

Clinicopathological feature of young gastric cancer showed significant preponderance for female occurrence, poorly differentiation and Borrmann 5 type. In background mucosa of young gastric cancer, more neutrophilic infiltration, less atrophy and intestinal metaplasia were observed rather than non-young gastric cancer cases. Further, higher LAT1 expression was observed. The difference was not identified between young gastric cancer cases and non-young gastric cancer cases view point of microsatellite instability and methylation status. However, there was a weak tendency that high prevalence of the loss of hMLH-1 expression in non-young gastric cancer. Therefore, abnormality of DNA repair gene might be correlated with the occurrence of non-young gastric cancer rather than young gastric cancer. Young gastric cancer patients showed better prognosis. However, prognostic factor was not identified in this research.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (1 results)

All 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] High expression of L-type amino-acid transporter 1 (LAT1) in gastric carcinomas : Comparison with non-cancerous lesions.2011

    • Author(s)
      Ichinoe M, Mikami T, Yoshida T, Igawa I, Tsuruta T, Nakada N, Anzai N, Suzuki Y, Endou H, Okayasu I.
    • Journal Title

      Pathol Int. 61(5)

      Pages: 281-289

    • NAID

      10031185084

    • Related Report
      2010 Final Research Report
    • Peer Reviewed

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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