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Definition of human cardiomyogenic differentiation factor

Research Project

Project/Area Number 21790373
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionKyoto Prefectural University of Medicine (2011-2012)
Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2010)
Yokohama National University (2009)

Principal Investigator

KAMI Daisuke  京都府立医科大学, 医学研究科, 助教 (80415588)

Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords分化誘導 / 心筋細胞 / 液性因子 / 遺伝子導入 / 心筋分化 / 間葉系幹細胞 / 再生医療
Research Abstract

Differentiation into cardiomyocytes is depended to cell differentiated state, expression genes, and extracellular environment. This idea could play important role in next step for cardiomyogenic differentiation.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (32 results)

All 2012 2011 2010 2009

All Journal Article (11 results) (of which Peer Reviewed: 8 results) Presentation (20 results) Book (1 results)

  • [Journal Article] Impaired CXCL4 expression in tumor-associated macrophages (TAMs) of ovarian cancers arising in endometriosis2012

    • Author(s)
      Furuya M, Tanaka R, Miyagi E, Kami D, Nagahama K, Miyagi Y, Nagashima Y, Hirahara F, Inayama Y, Aoki I.
    • Journal Title

      Cancer Biol Ther

      Volume: 13(8) Pages: 671-680

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of angiotensin II receptor-like 1 in the placentas of pregnancy-induced hypertension2012

    • Author(s)
      Furuya M, Okuda M, Usui H, Takenouchi T, Kami D, Nozawa A, Shozu M, Umezawa A, Takahashi T, Aoki I
    • Journal Title

      Int J Gynecol Pathol

      Volume: 31(3) Pages: 227-235

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Placenta to Cartilage: Direct conversion of human placenta to chondrocytes with transformation by defined factors2012

    • Author(s)
      Kami D, Ishii R, Toyoda M, Makino H, Gojo S, Ishii T, Umezawa A
    • Journal Title

      Mol Biol Cell.

      Volume: 23(18) Issue: 18 Pages: 3511-21

    • DOI

      10.1091/mbc.e11-10-0869

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amniotic membrane-derived mesenchymal stromal cell transplantation2012

    • Author(s)
      Kimura M, Toyoda M, Gojo S Itakura Y, Kami D, Miyoshi S, Kyo S, Ono M, Umezawa A
    • Journal Title

      J Stemcells & Regenerative Med

      Volume: Vol8 No.3 Pages: 171-180

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amniotic membrane-derived mesenchymal stromal cell transplantation2012

    • Author(s)
      Kimura M
    • Journal Title

      J Stemcells & Regenerative Med

      Volume: 8 Pages: 171-180

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of the Magnetic Nanoparticles to Gene Delivery2011

    • Author(s)
      D. Kami, S. Takeda, Y. Itakura, S. Gojo, M. Watanabe, and M. Toyoda
    • Journal Title

      Int. J. Mol. Sci

      Volume: 12 Issue: 6 Pages: 3705-3722

    • DOI

      10.3390/ijms12063705

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient transfection method using deacylated polyethylenimine-coated magnetic nanoparticles2011

    • Author(s)
      D. Kami, S. Takeda, M. Hatsune, M. Toyoda, Y. Itakura, S. Gojo, S. Kyo, A. Umezawa, M. Watanabe
    • Journal Title

      J. Artif. Organs

      Volume: 14 Issue: 3 Pages: 215-222

    • DOI

      10.1007/s10047-011-0568-6

    • NAID

      10030338996

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dystrophin conferral using human endothelium expressing HLA-E in the non-immunosuppressive murine model of Duchenne muscular dystrophy2011

    • Author(s)
      Cui CH, Miyoshi S, Tsuji H, Makino H, Kanzaki S, Kami D, Terai M, Suzuki H, Umezawa A
    • Journal Title

      Hum Mol Genet

      Volume: 15 Issue: 2 Pages: 235-244

    • DOI

      10.1093/hmg/ddq458

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] (特集)臨床工学技士が知っておきたい人工臓器と再生医療の展望:心臓における再生医療2011

    • Author(s)
      上大介
    • Journal Title

      Clinical Engineering

      Volume: 22 Pages: 9-14

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 心筋再生医療の現状-細胞移植療法を用いた再生医療-2010

    • Author(s)
      上大介
    • Journal Title

      Heart view

      Volume: 14 Pages: 116-120

    • Related Report
      2010 Annual Research Report
  • [Journal Article] マイクロアレイとNIA array analysisを用いた心筋分化誘導因子の探索2009

    • Author(s)
      上大介
    • Journal Title

      医学のあゆみ 229

      Pages: 1085-1085

    • Related Report
      2009 Annual Research Report
  • [Presentation] Construction of large amounts culture system by an automated cell processing machine for the cell transplantation2012

    • Author(s)
      Daisuke Kami, Masashi Toyoda, Naofumi Takehara, Hiroaki Matsubara, Satoshi Gojo
    • Organizer
      第9回心血管幹細胞研究会
    • Place of Presentation
      品川プリンスホテル
    • Year and Date
      2012-01-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Efficient Transfection method using the Magnetic nanoparticles and Episomal vector2012

    • Author(s)
      Daisuke Kami, Masashi Toyoda, Atsushi Kishida, Osam Mazda, Akihiro Umezawa, Masatoshi Watanabe, Hiroaki Matsubara, Satoshi Gojo
    • Organizer
      9th International Conference on the Scientific and Clinical Use of Magnetic Carriers
    • Place of Presentation
      University of Minnesota
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト右心耳由来心筋幹細胞の遺伝子導入による心筋分化誘導2012

    • Author(s)
      上大介, 豊田雅士, 板倉陽子, 松原弘明, 梅澤明弘, 五條理志
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] iPS 細胞の早期・効率的取得を目指したキャピラリー等電点電気泳動法の開発2012

    • Author(s)
      上大介、高橋慎、豊田雅士、松原弘明、関澤隆一、渡邉昌俊、梅澤明弘、五條理志
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] CONSTRUCTION OF LARGE AMOUNTS CULTURE SYSTEM BY AN AUTOMATED CELL PROCESSING MACHINE FOR THE CELL TRANSPLANTATION2012

    • Author(s)
      Daisuke Kami, Masashi Toyoda, Mayu Yamazaki-Inoue, Naofumi Takehara, Takehiro Ogata, Hiroaki Matsubara, Akihiro Umezawa, Satoshi Gojo
    • Organizer
      International Society for Stem Cell Research 10th Annual Meeting
    • Place of Presentation
      Yokohama
    • Related Report
      2012 Final Research Report
  • [Presentation] BASIC RESEARCH OF THE IMMUNO ASSAY BY THE CAPILLARY ISOELECTRIC FOCUSING FOR EFFICIENT ACQUISITION OF THE IPS CELL2012

    • Author(s)
      Daisuke Kami, Makoto Takahashi, Masashi Toyoda, Ryuichi Sekizawa, Hiroaki Matsubara, Akihiro Umezawa, Satoshi Gojo
    • Organizer
      International Society for Stem Cell Research 10th Annual Meeting
    • Place of Presentation
      Yokohama
    • Related Report
      2012 Final Research Report
  • [Presentation] DEVELOPMENT OF HIGH EFFICIENT GENE DELIVERY SYSTEM USING EPISOMAL VECTOR AND MAGNETIC NANOPARTICLES FOR PRODUCTION OF IPSCS2012

    • Author(s)
      Daisuke Kami, Masashi Toyoda, Atsushi Kishida, Osam Mazda, Hiroaki Matsubara,Akihiro Umezawa, Satoshi Gojo
    • Organizer
      International Society for Stem Cell Research 10th Annual Meeting
    • Place of Presentation
      Yokohama
    • Related Report
      2012 Final Research Report
  • [Presentation] PLACENTA TO CARTILAGE: DIRECT CONVERSION OF HUMAN PLACENTA TO CHONDROCYTES WITH TRANSFORMATION BY DEFINED FACTORS2012

    • Author(s)
      Daisuke Kami, Ryuga Ishii, Masashi Toyoda, Hatsune Makino, Satoshi Gojo,Akihiro Umezawa
    • Organizer
      ISSCR-Roddenberry International Symposium on Cellular Reprogramming
    • Place of Presentation
      GLADSTONE INSTITUTES, San Francisco
    • Related Report
      2012 Final Research Report
  • [Presentation] Efficient Transfection method using the Magnetic nanoparticles and Episomal vector2012

    • Author(s)
      Kami D
    • Organizer
      9th International Conference on the Scientific and Clinical Use of Magnetic Carriers.
    • Place of Presentation
      University of Minnesota
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト右心耳由来心筋幹細胞の遺伝子導入による心筋分化誘導2012

    • Author(s)
      上大介
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      横浜パシフィコ
    • Related Report
      2012 Annual Research Report
  • [Presentation] iPS細胞の早期・効率的取得を目指したキャピラリー等電点電気泳動法の開発2012

    • Author(s)
      上大介
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      横浜パシフィコ
    • Related Report
      2012 Annual Research Report
  • [Presentation] CONSTRUCTION OF LARGE AMOUNTS CULTURE SYSTEM BY AN AUTOMATED CELL PROCESSING MACHINE FOR THE CELL TRANSPLANTATION2012

    • Author(s)
      Kami D
    • Organizer
      International Society for Stem Cell Research 10th Annual Meeting
    • Place of Presentation
      Pacifico Yokohama
    • Related Report
      2012 Annual Research Report
  • [Presentation] BASIC RESEARCH OF THE IMMUNO ASSAY BY THE CAPILLARY ISOELECTRIC FOCUSING FOR EFFICIENT ACQUISITION OF THE IPS CELL2012

    • Author(s)
      Kami D
    • Organizer
      International Society for Stem Cell Research 10th Annual Meeting
    • Place of Presentation
      Pacifico Yokohama
    • Related Report
      2012 Annual Research Report
  • [Presentation] DEVELOPMENT OF HIGH EFFICIENT GENE DELIVERY SYSTEM USING EPISOMAL VECTOR AND MAGNETIC NANOPARTICLES FOR PRODUCTION OF IPSCS2012

    • Author(s)
      Kami D
    • Organizer
      International Society for Stem Cell Research 10th Annual Meeting
    • Place of Presentation
      Pacifico Yokohama
    • Related Report
      2012 Annual Research Report
  • [Presentation] PLACENTA TO CARTILAGE: DIRECT CONVERSION OF HUMAN PLACENTA TO CHONDROCYTES WITH TRANSFORMATION BY DEFINED FACTORS2012

    • Author(s)
      Kami D
    • Organizer
      ISSCR-Roddenberry International Symposium on Cellular Reprogramming
    • Place of Presentation
      GLADSTONE INSTITUTES
    • Related Report
      2012 Annual Research Report
  • [Presentation] 磁性ナノ粒子を用いた高効率な遺伝子導入法の開発と再生医療への応用2011

    • Author(s)
      上大介、武田祥吾、板倉陽子、豊田雅士、五條理志
    • Organizer
      第49回日本人工臓器学会大会
    • Place of Presentation
      都市センターホテル
    • Year and Date
      2011-11-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] ラット右心耳由来細胞の細胞移植療法に向けた特性解析2011

    • Author(s)
      上大介
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胎盤由来血管内皮細胞の樹立と特性解析2010

    • Author(s)
      上大介
    • Organizer
      第48回日本人工臓器学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトiPS細胞株間における遺伝子発現解析と心筋分化誘導2010

    • Author(s)
      上大介
    • Organizer
      第58回日本心臓病学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] BMPアンタゴニストGrem1を用いた心筋分化誘導2010

    • Author(s)
      上大介
    • Organizer
      第9回再生心臓血管外科治療研究会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-02-15
    • Related Report
      2009 Annual Research Report
  • [Book] ものづくり技術からみる再生医療-細胞研究・創薬・治療-第10章-細胞の評価技術-2011

    • Author(s)
      上大介、豊田雅士、板倉陽子、五條理志、梅澤明弘
    • Total Pages
      8
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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