Definition of human cardiomyogenic differentiation factor

• Project/Area Number: 21790373
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: Kyoto Prefectural University of Medicine (2011-2012); Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2010); Yokohama National University (2009)
• Principal Investigator: KAMI Daisuke 京都府立医科大学, 医学研究科, 助教 (80415588)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 分化誘導 / 心筋細胞 / 液性因子 / 遺伝子導入 / 心筋分化 / 間葉系幹細胞 / 再生医療

Research Abstract

Differentiation into cardiomyocytes is depended to cell differentiated state, expression genes, and extracellular environment. This idea could play important role in next step for cardiomyogenic differentiation.

Research Products

• [Journal Article] Impaired CXCL4 expression in tumor-associated macrophages (TAMs) of ovarian cancers arising in endometriosis (2012)
  • Author(s): Furuya M, Tanaka R, Miyagi E, Kami D, Nagahama K, Miyagi Y, Nagashima Y, Hirahara F, Inayama Y, Aoki I.
  • Journal Title: Cancer Biol Ther Volume: 13(8) Pages: 671-680
  • Peer Reviewed
• [Journal Article] Expression of angiotensin II receptor-like 1 in the placentas of pregnancy-induced hypertension (2012)
  • Author(s): Furuya M, Okuda M, Usui H, Takenouchi T, Kami D, Nozawa A, Shozu M, Umezawa A, Takahashi T, Aoki I
  • Journal Title: Int J Gynecol Pathol Volume: 31(3) Pages: 227-235
  • Peer Reviewed
• [Journal Article] Placenta to Cartilage: Direct conversion of human placenta to chondrocytes with transformation by defined factors (2012)
  • Author(s): Kami D, Ishii R, Toyoda M, Makino H, Gojo S, Ishii T, Umezawa A
  • Journal Title: Mol Biol Cell. Volume: 23(18) Issue: 18 Pages: 3511-21
  • DOI: 10.1091/mbc.e11-10-0869
  • Peer Reviewed
• [Journal Article] Amniotic membrane-derived mesenchymal stromal cell transplantation (2012)
  • Author(s): Kimura M, Toyoda M, Gojo S Itakura Y, Kami D, Miyoshi S, Kyo S, Ono M, Umezawa A
  • Journal Title: J Stemcells & Regenerative Med Volume: Vol8 No.3 Pages: 171-180
  • Peer Reviewed
• [Journal Article] Amniotic membrane-derived mesenchymal stromal cell transplantation (2012)
  • Author(s): Kimura M
  • Journal Title: J Stemcells & Regenerative Med Volume: 8 Pages: 171-180
  • Peer Reviewed
• [Journal Article] Application of the Magnetic Nanoparticles to Gene Delivery (2011)
  • Author(s): D. Kami, S. Takeda, Y. Itakura, S. Gojo, M. Watanabe, and M. Toyoda
  • Journal Title: Int. J. Mol. Sci Volume: 12 Issue: 6 Pages: 3705-3722
  • DOI: 10.3390/ijms12063705
  • Peer Reviewed
• [Journal Article] Efficient transfection method using deacylated polyethylenimine-coated magnetic nanoparticles (2011)
  • Author(s): D. Kami, S. Takeda, M. Hatsune, M. Toyoda, Y. Itakura, S. Gojo, S. Kyo, A. Umezawa, M. Watanabe
  • Journal Title: J. Artif. Organs Volume: 14 Issue: 3 Pages: 215-222
  • DOI: 10.1007/s10047-011-0568-6
  • NAID: 10030338996
  • Peer Reviewed
• [Journal Article] Dystrophin conferral using human endothelium expressing HLA-E in the non-immunosuppressive murine model of Duchenne muscular dystrophy (2011)
  • Author(s): Cui CH, Miyoshi S, Tsuji H, Makino H, Kanzaki S, Kami D, Terai M, Suzuki H, Umezawa A
  • Journal Title: Hum Mol Genet Volume: 15 Issue: 2 Pages: 235-244
  • DOI: 10.1093/hmg/ddq458
  • Peer Reviewed
• [Journal Article] (特集)臨床工学技士が知っておきたい人工臓器と再生医療の展望:心臓における再生医療 (2011)
  • Author(s): 上大介
  • Journal Title: Clinical Engineering Volume: 22 Pages: 9-14
• [Journal Article] 心筋再生医療の現状-細胞移植療法を用いた再生医療- (2010)
  • Author(s): 上大介
  • Journal Title: Heart view Volume: 14 Pages: 116-120
• [Journal Article] マイクロアレイとNIA array analysisを用いた心筋分化誘導因子の探索 (2009)
  • Author(s): 上大介
  • Journal Title: 医学のあゆみ 229 Pages: 1085-1085
• [Presentation] Construction of large amounts culture system by an automated cell processing machine for the cell transplantation (2012)
  • Author(s): Daisuke Kami, Masashi Toyoda, Naofumi Takehara, Hiroaki Matsubara, Satoshi Gojo
  • Organizer: 第9回心血管幹細胞研究会
  • Place of Presentation: 品川プリンスホテル
  • Year and Date: 2012-01-14
• [Presentation] Efficient Transfection method using the Magnetic nanoparticles and Episomal vector (2012)
  • Author(s): Daisuke Kami, Masashi Toyoda, Atsushi Kishida, Osam Mazda, Akihiro Umezawa, Masatoshi Watanabe, Hiroaki Matsubara, Satoshi Gojo
  • Organizer: 9th International Conference on the Scientific and Clinical Use of Magnetic Carriers
  • Place of Presentation: University of Minnesota
• [Presentation] ヒト右心耳由来心筋幹細胞の遺伝子導入による心筋分化誘導 (2012)
  • Author(s): 上大介, 豊田雅士, 板倉陽子, 松原弘明, 梅澤明弘, 五條理志
  • Organizer: 第11回日本再生医療学会総会
  • Place of Presentation: 横浜
• [Presentation] iPS 細胞の早期・効率的取得を目指したキャピラリー等電点電気泳動法の開発 (2012)
  • Author(s): 上大介、高橋慎、豊田雅士、松原弘明、関澤隆一、渡邉昌俊、梅澤明弘、五條理志
  • Organizer: 第11回日本再生医療学会総会
  • Place of Presentation: 横浜
• [Presentation] CONSTRUCTION OF LARGE AMOUNTS CULTURE SYSTEM BY AN AUTOMATED CELL PROCESSING MACHINE FOR THE CELL TRANSPLANTATION (2012)
  • Author(s): Daisuke Kami, Masashi Toyoda, Mayu Yamazaki-Inoue, Naofumi Takehara, Takehiro Ogata, Hiroaki Matsubara, Akihiro Umezawa, Satoshi Gojo
  • Organizer: International Society for Stem Cell Research 10th Annual Meeting
  • Place of Presentation: Yokohama
• [Presentation] BASIC RESEARCH OF THE IMMUNO ASSAY BY THE CAPILLARY ISOELECTRIC FOCUSING FOR EFFICIENT ACQUISITION OF THE IPS CELL (2012)
  • Author(s): Daisuke Kami, Makoto Takahashi, Masashi Toyoda, Ryuichi Sekizawa, Hiroaki Matsubara, Akihiro Umezawa, Satoshi Gojo
  • Organizer: International Society for Stem Cell Research 10th Annual Meeting
  • Place of Presentation: Yokohama
• [Presentation] DEVELOPMENT OF HIGH EFFICIENT GENE DELIVERY SYSTEM USING EPISOMAL VECTOR AND MAGNETIC NANOPARTICLES FOR PRODUCTION OF IPSCS (2012)
  • Author(s): Daisuke Kami, Masashi Toyoda, Atsushi Kishida, Osam Mazda, Hiroaki Matsubara,Akihiro Umezawa, Satoshi Gojo
  • Organizer: International Society for Stem Cell Research 10th Annual Meeting
  • Place of Presentation: Yokohama
• [Presentation] PLACENTA TO CARTILAGE: DIRECT CONVERSION OF HUMAN PLACENTA TO CHONDROCYTES WITH TRANSFORMATION BY DEFINED FACTORS (2012)
  • Author(s): Daisuke Kami, Ryuga Ishii, Masashi Toyoda, Hatsune Makino, Satoshi Gojo,Akihiro Umezawa
  • Organizer: ISSCR-Roddenberry International Symposium on Cellular Reprogramming
  • Place of Presentation: GLADSTONE INSTITUTES, San Francisco
• [Presentation] Efficient Transfection method using the Magnetic nanoparticles and Episomal vector (2012)
  • Author(s): Kami D
  • Organizer: 9th International Conference on the Scientific and Clinical Use of Magnetic Carriers.
  • Place of Presentation: University of Minnesota
• [Presentation] ヒト右心耳由来心筋幹細胞の遺伝子導入による心筋分化誘導 (2012)
  • Author(s): 上大介
  • Organizer: 第11回日本再生医療学会総会
  • Place of Presentation: 横浜パシフィコ
• [Presentation] iPS細胞の早期・効率的取得を目指したキャピラリー等電点電気泳動法の開発 (2012)
  • Author(s): 上大介
  • Organizer: 第11回日本再生医療学会総会
  • Place of Presentation: 横浜パシフィコ
• [Presentation] CONSTRUCTION OF LARGE AMOUNTS CULTURE SYSTEM BY AN AUTOMATED CELL PROCESSING MACHINE FOR THE CELL TRANSPLANTATION (2012)
  • Author(s): Kami D
  • Organizer: International Society for Stem Cell Research 10th Annual Meeting
  • Place of Presentation: Pacifico Yokohama
• [Presentation] BASIC RESEARCH OF THE IMMUNO ASSAY BY THE CAPILLARY ISOELECTRIC FOCUSING FOR EFFICIENT ACQUISITION OF THE IPS CELL (2012)
  • Author(s): Kami D
  • Organizer: International Society for Stem Cell Research 10th Annual Meeting
  • Place of Presentation: Pacifico Yokohama
• [Presentation] DEVELOPMENT OF HIGH EFFICIENT GENE DELIVERY SYSTEM USING EPISOMAL VECTOR AND MAGNETIC NANOPARTICLES FOR PRODUCTION OF IPSCS (2012)
  • Author(s): Kami D
  • Organizer: International Society for Stem Cell Research 10th Annual Meeting
  • Place of Presentation: Pacifico Yokohama
• [Presentation] PLACENTA TO CARTILAGE: DIRECT CONVERSION OF HUMAN PLACENTA TO CHONDROCYTES WITH TRANSFORMATION BY DEFINED FACTORS (2012)
  • Author(s): Kami D
  • Organizer: ISSCR-Roddenberry International Symposium on Cellular Reprogramming
  • Place of Presentation: GLADSTONE INSTITUTES
• [Presentation] 磁性ナノ粒子を用いた高効率な遺伝子導入法の開発と再生医療への応用 (2011)
  • Author(s): 上大介、武田祥吾、板倉陽子、豊田雅士、五條理志
  • Organizer: 第49回日本人工臓器学会大会
  • Place of Presentation: 都市センターホテル
  • Year and Date: 2011-11-26
• [Presentation] ラット右心耳由来細胞の細胞移植療法に向けた特性解析 (2011)
  • Author(s): 上大介
  • Organizer: 第10回日本再生医療学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-01
• [Presentation] 胎盤由来血管内皮細胞の樹立と特性解析 (2010)
  • Author(s): 上大介
  • Organizer: 第48回日本人工臓器学会大会
  • Place of Presentation: 仙台
  • Year and Date: 2010-11-19
• [Presentation] ヒトiPS細胞株間における遺伝子発現解析と心筋分化誘導 (2010)
  • Author(s): 上大介
  • Organizer: 第58回日本心臓病学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-17
• [Presentation] BMPアンタゴニストGrem1を用いた心筋分化誘導 (2010)
  • Author(s): 上大介
  • Organizer: 第9回再生心臓血管外科治療研究会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-02-15
• [Book] ものづくり技術からみる再生医療-細胞研究・創薬・治療-第10章-細胞の評価技術- (2011)
  • Author(s): 上大介、豊田雅士、板倉陽子、五條理志、梅澤明弘
  • Total Pages: 8
  • Publisher: シーエムシー出版