The effect of extracellular ATP on LPS-induced endotoxin shock in mice.
| Project/Area Number |
21790381
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Niigata University |
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Principal Investigator |
KAWAMURA Hiroki Niigata University, 医歯学系, 講師 (20333495)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | マクロファージ / ATP / エンドトキシン / 好中球 / MIP-2 / LPS / IL-1β / エンドトキシンショック |
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| Research Abstract |
Extracellular ATP leads to immune responses in a wide spectrum of cell types (e.g., macrophages, T cells) and tissues. However, it remains unclear whether such ATP-activated macrophages modulate the magnitude of immune responses to actual tissue injury. Thus, we investigated the role of ATP-mediated inflammatory response by macrophages in LPS-induced endotoxin shock. This study indicated that the binding of extracellular ATP to P2purinergic receptors on macrophages increases neutrophil infiltration via the production of MIP-2. However, in this pathway, further examination was required because P2purinergic receptor of the having many kinds was related.
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Report
(3 results)
Research Products
(12 results)
