| Project/Area Number |
21790389
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Oita University |
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Principal Investigator |
NAKADA Chisato Oita University, 医学部, 助教 (60379625)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | microRNA / 腎細胞癌 |
|---|
| Research Abstract |
It has recently been reported that microRNAs (miRNAs), non-protein-coding small RNAs comprising about 22 nucleotides, are aberrantly expressed in certain carcinomas and play oncogenic or tumor-suppressive roles in carcinoma cells. The aim of this project is to clarify the functions of the miRNAs aberrantly expressed in clear cell renal cell carcinoma (CCC), and to identify miRNAs associated with carcinogenesis and/or cancer progression.
Three miRNAs are found deregulated in CCC, but the mechanism and biological consequences of their deregulation are poorly understood. MiR-200c and miR-141 are significantly downregulated in CCC. Ectopic expression of these miRNAs induced growth suppression of renal carcinoma cell lines. Ectopic expression of miR-210, which is upregulated in CCC, caused accumulation at G2/M phase of the cell cycle associated with multipolar spindle, suggesting that miR-210 overexpression may trigger an event that hinders normal cell division.
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