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Complement receptor 2 is expressed by neural progenitor cells and regulates adult hippocampal neurogenesis in mice

Research Project

Project/Area Number 21790393
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionJuntendo University

Principal Investigator

HASEGAWA Maiko  Juntendo University, 医学部, 助教 (20516637)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords補体受容体 / 神経新生 / 神経幹細胞
Research Abstract

Complement receptor 2 (CR2) is expressed by neural progenitor cells and inhibits differentiation to neural lineage. Adult neurogenesis was increased in the dentate gyrus of CR2 deficient mice, indicating that neurogenesis might be promoted by down-regulating CR2 signaling.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (4 results)

All 2010 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis.

    • Author(s)
      Hasegawa-Moriyama M, Fukuhara T, Britchgi M, Villeda SA, Narasimhan R, Molina HD, Wyss-Coray T
    • Journal Title

      Journal of Neuroscience in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis.

    • Author(s)
      Hasegawa-Moriyama M, Fukuhara T, Britschgi M, Villeda SA, Narasimhan R, Molina HD, Wyss-Coray T
    • Journal Title

      Journal of Neuroscience

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Complement receptor 2 is expressed by neural progenitor cells and regulates adult hippocampal neurogenesis in mice.2010

    • Author(s)
      T.Fukuhara, M.Moriyama, M.Britschgi, S.A.Villeda, R.Narasimhan, H.D.Molina, T.Wyss-Coray
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis.

    • Author(s)
      Fukuhara T , Moriyama M, Britchgi M, Villeda SA, Narasimhan R, Molina HD, Wyss-Coray T
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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