Development of brain tumor mouse models reflecting human counterparts

• Project/Area Number: 21790398
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Experimental pathology
• Research Institution: Nagoya University
• Principal Investigator: MOMOTA Hiroyuki 名古屋大学, 医学部附属病院, 病院助教 (60469971)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 癌 / 応用動物 / 病理学 / 脳神経疾患 / トランスレーショナルリサーチ

Research Abstract

We have successfully established PDGFB-induced malignant glioma and Shh-induced medulloblastoma mouse models by using RCAS/tv-a system. These are the first brain tumor mouse models created by RCAS/tv-a system in Japan. We have also developed novel mouse models of medulloblastoma by using RCAS-p53 short hairpin or RCAS-c-Myc. A novel method of intracranial injection for brain tumor mouse models is invented by the support of this grant and has been published(J Neurosurg. 2012. 116 : 630-635).

Research Products

• [Journal Article] The Global DNA Methylation Surrogate LINE-1 Methylation Is Correlated with MGMT Promoter Methylation and Is a Better Prognostic Factor for Glioma (2011)
  • Author(s): Ohka F, Natsume A, Motomura K, Kishida Y, Kondo Y, Abe T, Nakasu Y, Namba H, Wakai K, Fukui T, Momota H, Iwami K, Kinjo S, Ito M, Fujii M, Wakabayashi T
  • Journal Title: PLoS One Volume: Vol.6 Pages: 23332-23332
  • Peer Reviewed
• [Journal Article] Long-term survival in patients with newly diagnosed primary central nervous system lymphoma treated with dexamethasone, etoposide, ifosfamide and carboplatin chemotherapy and whole-brain radiation the rap (2011)
  • Author(s): Motomura K, Natsume A, Fujii M, Ito M, Momota H, Wakabayashi T
  • Journal Title: Leuk Lymphoma Volume: Vol.52、No.11 Pages: 2069-2075
  • Peer Reviewed
• [Journal Article] A novel method of intracranial injection via postglenoid foramen for brain tumor mouse models (2011)
  • Author(s): Iwami K, Momota H, Natsume A, Kinjo S, Nagatani T, Wakabayashi T
  • Journal Title: J Neurosurg Volume: Vol.116、No.3 Pages: 630-635
  • Peer Reviewed
• [Journal Article] Rhabdoid glioblastoma in achild : case report and literature review (2011)
  • Author(s): Momota H, Iwami K, Fujii M, Motomura K, Natsume A, Ogino J, Hasegawa T, Wakabayashi T
  • Journal Title: Brain Tumor Pathol Volume: Vol.28、No.1 Pages: 65-70
  • Peer Reviewed
• [Journal Article] Rhabdoid glioblastoma in a child : case report and literature review (2011)
  • Author(s): Momota H, Iwami K. Fujii M, Motomura K, Natsume A, Ogino J, Hasegawa T, Wakabayashi T
  • Journal Title: Brain Tumor Pathol Volume: 28 Issue: 1 Pages: 65-70
  • DOI: 10.1007/s10014-010-0010-4
  • Peer Reviewed
• [Journal Article] p53 abnormality and tumor invasion in patients with malignant astrocytoma (2010)
  • Author(s): Momota H, Narita Y, Matsushita Y, Miyakita Y, Shibui S
  • Journal Title: Brain Tumor Pathol Volume: Vol.27、No.2 Pages: 95-101
  • Peer Reviewed
• [Journal Article] Glioblastoma simultaneously present with adjacent meningioma : case report and review of the literature (2010)
  • Author(s): Suzuki K, Momota H, Tonooka A, Noguchi H, Yamamoto K, Wanibuchi M, Minamida Y, Hasegawa T, Houkin K
  • Journal Title: J Neurooncol Volume: Vol.99、No.1 Pages: 147-153
  • Peer Reviewed
• [Journal Article] Acute lymphoblastic leukemia after temozolomide treatment for anaplastic astrocytoma in a child with agermline TP53 mutation (2010)
  • Author(s): Momota H, Narita Y, Miyakita Y, Hosono A, Makimoto A, Shibui S
  • Journal Title: Pediatr Blood Cancer Volume: Vol.55、No.3 Pages: 577-579
  • Peer Reviewed
• [Journal Article] Prognostic value of immunohistochemical profile and response to high-dose methotrexate therapy in primary CNS lymphoma (2010)
  • Author(s): Momota H, Narita Y, Maeshima AM, Miyakita Y, Shinomiya A, Maruyama T, Muragaki Y, Shibui S
  • Journal Title: J Neurooncol Volume: Vol.98、No.3 Pages: 341-318
  • Peer Reviewed
• [Journal Article] Prognostic value of immunohistochemical profile and response to high-dose methotrexate therapy in primary CNS lymphoma. (2010)
  • Author(s): Momota H, Narita Y, Maeshima AM, Miyakita Y, Shinomiya A, Maruyama T, Muragaki Y, Shibui S.
  • Journal Title: J Neurooncol. Volume: 98 Pages: 341-318
  • Peer Reviewed
• [Journal Article] Glioblastoma simultaneously present with adjacent meningioma : case report and review of the literature. (2010)
  • Author(s): Suzuki K, Momota H, Tonooka A, Noguchi H, Yamamoto K, Wanibuchi M, Minamida Y, Hasegawa T, Houkin K.
  • Journal Title: J Neurooncol. Volume: 99 Pages: 147-153
  • Peer Reviewed
• [Journal Article] Acute lymphoblastic leukemia after temozolomide treatment for anaplastic astrocytoma in a child with a germline TP53 mutation. (2010)
  • Author(s): Momota H, Narita Y, Miyakita Y, Hosono A, Makimoto A, Shibui S.
  • Journal Title: Pediatr Blood Cancer. Volume: 55 Pages: 577-579
  • Peer Reviewed
• [Journal Article] p53 abnormality and tumor invasion in patients with malignant astrocytoma. (2010)
  • Author(s): Momota H, Narita Y, Matsushita Y, Miyakita Y, Shibui S.
  • Journal Title: Brain Tumor Pathol. Volume: 27 Pages: 95-101
  • Peer Reviewed
• [Journal Article] 悪性神経膠腫患者に対する告知・終末期医療の現状報告-日本脳腫瘍学会員へのアンケート調査報告 (2009)
  • Author(s): 成田善孝、宮北康二、百田洋之、宮原るり子、渋井壮一郎
  • Journal Title: 脳神経外科 Volume: Vol.37、No.10 Pages: 973-981
• [Journal Article] Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations (2009)
  • Author(s): Brennan C, Momota H, Hambardzumyan D, Ozawa T, Tandon A, Pedraza A, Holland E
  • Journal Title: PLoS One Volume: Vol.4 Pages: 7752-7752
  • Peer Reviewed
• [Journal Article] Mouse models ofCNS embryonal tumors (2009)
  • Author(s): Momota H, Holland EC
  • Journal Title: Brain Tumor Pathol Volume: Vol.26、No.2 Pages: 43-50
  • Peer Reviewed
• [Journal Article] Mouse models of CNS embryonal tumors. (2009)
  • Author(s): Momota H, Holland EC.
  • Journal Title: Brain Tumor Pathol. Volume: 26 Pages: 43-50
  • Peer Reviewed
• [Journal Article] 悪性神経膠腫患者に対する告知・終末期医療の現状報告-日本脳腫瘍学会員へのアンケート調査報告 (2009)
  • Author(s): 成田善孝, 宮北康二, 百田洋之, 宮原るり子, 渋井壮一郎
  • Journal Title: 脳神経外科 Volume: 37 Pages: 973-981
  • Peer Reviewed
• [Journal Article] Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations. (2009)
  • Author(s): Brennan C, Momota H (co-first author), Hambardzumyan D, Ozawa T, Tandon A, Pedraza A, Holland E.
  • Journal Title: PLoS One. Volume: 4
  • Peer Reviewed
• [Presentation] ヒト脳腫瘍の分子異常を反映したマウスモデルの開発 (2011)
  • Author(s): 百田洋之, 他
  • Organizer: ポスター、第29回日本脳腫瘍学会学術集会
  • Place of Presentation: 下呂温泉水明館(岐阜)
  • Year and Date: 2011-11-27
• [Presentation] ヒト脳腫瘍の分子異常を反映したマウスモデルの開発 (2011)
  • Author(s): 百田洋之、金城清乃、加藤彰、夏目敦至、若林俊彦
  • Organizer: 第29回日本脳腫瘍学会学術集会
  • Place of Presentation: 下呂温泉水明館(岐阜)
  • Year and Date: 2011-11-27
• [Presentation] 放射線治療の強度を落とし晩期合併症の軽減を目指した大量化学療法による小児CNS embryonal tumorの治療成績、口演 (2011)
  • Author(s): 百田洋之, 他
  • Organizer: 第70回社団法人日本脳神経外科学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-10-12
• [Presentation] 放射線治療の強度を落とし晩期合併症の軽減を目指した大量化学療法による小児CNS embryonal tumorの治療成績 (2011)
  • Author(s): 百田洋之、藤井正純、本村和也、島戸真司、岩味健一郎、大岡史治、夏目敦至、若林俊彦
  • Organizer: 第70回社団法人日本脳神経外科学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-10-12
• [Presentation] Development of novelmouse models of medulloblastomas using the RCAS/tv-a gene transfer system、口演 (2011)
  • Author(s): Momota H, 他
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2011-10-04
• [Presentation] Development of novel mouse models of medulloblastomas using the RCAS/tv-a gene transfer system (2011)
  • Author(s): Hiroyuki Momota, Sayano Kinjo, Akira Kato, Atsushi Natsume, Toshihiko Wakabayashi
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2011-10-04
• [Presentation] PCNSL Basic Science Studies (2011)
  • Author(s): Momota H
  • Organizer: 招待講演、2011 Pan Pacific Lymphoma Conference
  • Place of Presentation: Grand Hyatt Kauai Resort & Spa(Koloa, HI, USA)
  • Year and Date: 2011-08-15
• [Presentation] 2011 PCNSL Basic Science Studies (2011)
  • Author(s): Hiroyuki Momota
  • Organizer: 2011 Pan Pacific Lymphoma Conference
  • Place of Presentation: Grand Hyatt Kauai Resort & Spa (Koloa, USA)(招待講演)
  • Year and Date: 2011-08-15
• [Presentation] 著明なpseudo progressionを示した小児視床部悪性神経膠腫の1例、口演 (2011)
  • Author(s): 百田洋之, 他
  • Organizer: 第29回脳腫瘍病理学会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 2011-05-21
• [Presentation] 著明なpseudoprogressionを示した小児視床部悪性神経膠腫の1例 (2011)
  • Author(s): 百田洋之、荻野次郎、鰐渕昌彦、南田善弘、長谷川匡
  • Organizer: 第29回脳腫瘍病理学会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 2011-05-21
• [Presentation] Developing novel mouse model of medulloblastoma reflecting molecular abnormalities and histologic features、口演 (2011)
  • Author(s): Kinjo S, Momota H, 他
  • Organizer: 第3回NAGOYAグローバルリトリート
  • Place of Presentation: 愛知健康プラザ(愛知)
  • Year and Date: 2011-02-25
• [Presentation] Developing novel mouse model of medulloblastoma reflecting molecular abnormalities and histologic features (2011)
  • Author(s): Kinjo S, Momota H, Natsume A, Wakabayashi T
  • Organizer: 第3回NAGOYAグローバルリトリート
  • Place of Presentation: 愛知健康プラザ(愛知)
  • Year and Date: 2011-02-25
• [Presentation] 膠芽腫におけるタンパク異常発現パターンの解析、ポスター (2010)
  • Author(s): 百田洋之, 他
  • Organizer: 第28回日本脳腫瘍学会
  • Place of Presentation: 軽井沢プリンスホテルウエスト(長野)
  • Year and Date: 2010-11-28
• [Presentation] 膠芽腫におけるタンパク異常発現パターンの解析 (2010)
  • Author(s): 百田洋之、本村和也、金城清乃、夏目敦至、若林俊彦
  • Organizer: 第28回日本脳腫瘍学会学術集会
  • Place of Presentation: 軽井沢プリンスホテルウエスト(長野)
  • Year and Date: 2010-11-28
• [Presentation] 小児のCNS embryonaltumorに対する末梢血幹細胞移植を用いた放射線化学療法の治療成績、口演 (2010)
  • Author(s): 百田洋之, 他
  • Organizer: 第69回社団法人日本脳神経外科学会学術集会
  • Place of Presentation: 福岡国際会議場(福岡)
  • Year and Date: 2010-10-27
• [Presentation] 小児のCNS embryonal tumorに対する末梢血幹細胞移植を用いた放射線化学療法の治療成績 (2010)
  • Author(s): 百田洋之、本村和也、岩味健一郎、夏目敦至、藤井正純、若林俊彦
  • Organizer: 第69回社団法人日本脳神経外科学会学術集会
  • Place of Presentation: 福岡国際会議場(福岡)
  • Year and Date: 2010-10-27
• [Presentation] 小児に発生した視床部神経膠腫の1例、口演 (2010)
  • Author(s): 百田洋之, 他
  • Organizer: 第29回東海脳腫瘍病理検討会
  • Place of Presentation: TKP名古屋ビジネスセンター(愛知)
  • Year and Date: 2010-09-11
• [Presentation] 小児に発生した視床部神経膠腫の1例 (2010)
  • Author(s): 百田洋之、藤井正純、若林俊彦、加藤省一、村上善子、下山芳江、中村栄男
  • Organizer: 第29回東海脳腫瘍病理検討会
  • Place of Presentation: TKP名古屋ビジネスセンター(愛知)
  • Year and Date: 2010-09-11
• [Presentation] Secondary hematological malignancies associated with temozolomide(TMZ) in patients with glioma (2010)
  • Author(s): Momota H, 他
  • Organizer: 46th American Society of Clinical Oncology(ASCO) Annual Meeting、ポスター
  • Place of Presentation: McCormick Place(Chicago, IL, USA)
  • Year and Date: 2010-06-06
• [Presentation] Secondary hematological malignancies associated with temozolomide (TMZ) in patients with glioma (2010)
  • Author(s): Momota H, Narita Y, Miyakita Y, Shibui S
  • Organizer: 46th American Society of Clinical Oncology (ASCO) Annual Meeting
  • Place of Presentation: McCormick Place (CHICAGO, IL, USA)
  • Year and Date: 2010-06-06
• [Presentation] Rhabdoid glioblastomaの一例とrhabdoid componentを持つ星細胞系腫瘍の文献的考察 (2010)
  • Author(s): 百田洋之, 他
  • Organizer: 第28回脳腫瘍病理学会、口演
  • Place of Presentation: 大阪市中央公会堂(大阪)
  • Year and Date: 2010-05-22
• [Presentation] Rhabdoid glioblastomaの一例とrhabdoid componentを持つ星細胞系腫瘍の文献的考察 (2010)
  • Author(s): 百田洋之、荻野次郎、鰐渕昌彦、南田善弘、長谷川匡
  • Organizer: 第28回脳腫瘍病理学会
  • Place of Presentation: 大阪市中央公会堂(大阪)
  • Year and Date: 2010-05-22
• [Presentation] Bioluminescence imagingの原理とマウスモデルへの応用 (2010)
  • Author(s): 百田洋之
  • Organizer: NAGOYA Global Retreat
  • Place of Presentation: 愛知健康プラザ(愛知)
  • Year and Date: 2010-02-26
• [Presentation] Glioblastoma subclasses defined by signal transduction pathway activity (2010)
  • Author(s): Momota H, 他
  • Organizer: NAGOYA Global Retreat
  • Place of Presentation: 愛知健康プラザ(愛知)
  • Year and Date: 2010-02-26
• [Presentation] Glioblastoma subclasses defined by signal transduction pathway activity (2010)
  • Author(s): Momota H, Natsume A, Wakabayashi T, Brennan C, Hambardzumyan D, Ozawa T, Tandon A, Pedraza A, Holland E
  • Organizer: 第2回NAGOYAグローバルリトリート
  • Place of Presentation: 愛知健康プラザ(愛知)
  • Year and Date: 2010-02-26
• [Presentation] Bioluminescence imagingの原理とマウスモデルへの応用 (2010)
  • Author(s): 百田洋之
  • Organizer: 第2回NAGOYAグローバルリトリート
  • Place of Presentation: 愛知健康プラザ(愛知)
  • Year and Date: 2010-02-26
• [Presentation] Mouse models for brain tumors (2009)
  • Author(s): Momota H, Natsume A, Wakabayashi T
  • Organizer: グローバルCOE第2回国際シンポジウム
  • Place of Presentation: 名古屋ヒルトンホテル(愛知)
  • Year and Date: 2009-11-27
• [Presentation] Mouse models for brain tumorsグローバルCOE (2009)
  • Author(s): Momota H, 他
  • Organizer: 第2回国際シンポジウム、ポスター
  • Place of Presentation: 名古屋ヒルトンホテル(愛知)
  • Year and Date: 2009-11-26
• [Presentation] 再発悪性神経膠腫に対するTemozolomide 7-days-on/7-days-off療法 (2009)
  • Author(s): 百田洋之, 他
  • Organizer: 第27回日本脳腫瘍学会、口演
  • Place of Presentation: 全日空ゲートタワーホテル大阪(大阪)
  • Year and Date: 2009-11-08
• [Presentation] 再発悪性神経膠腫に対するTemozolomide 7-days-on/7-days-off療法 (2009)
  • Author(s): 百田洋之、南田善弘、鈴木健吾、鰐渕昌彦、宝金清博
  • Organizer: 第27回日本脳腫瘍学会
  • Place of Presentation: 全日空ゲートタワーホテル大阪(大阪)
  • Year and Date: 2009-11-08
• [Presentation] Signal transduction and mouse models of brain tumors (2009)
  • Author(s): Momota H
  • Organizer: Swiss-Japanese Neurosurgical Joint Meeting 2009、口演
  • Place of Presentation: Sorell Hotel Zurichberg(Zurich, Switzerland)
  • Year and Date: 2009-07-24
• [Presentation] Signal transduction and mouse models of brain tumors (2009)
  • Author(s): Momota H
  • Organizer: Swiss-Japanese Neurosurgical Joint Meeting 2009
  • Place of Presentation: Sorell Hotel Zurichberg (ZURICH, SWITZERLAND)
  • Year and Date: 2009-07-24
• [Presentation] Expression and prognostic significance of differentiation markers in primary CNS lymphoma(PCNSL) (2009)
  • Author(s): Momota H, 他
  • Organizer: 45th American Society of Clinical Oncology(ASCO) Annual Meeting、Publication only
  • Place of Presentation: Orange Country Convention Center(Orlando, FL, USA)
  • Year and Date: 2009-05-29
• [Presentation] Mouse models of CNS embryonal tumors (2009)
  • Author(s): Momota H, 他
  • Organizer: The 3rd Quadrennial Meeting of the World Federation of Neuro-Oncology、口演
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-05-14
• [Presentation] Mouse models of CNS embryonal tumors (2009)
  • Author(s): Momota H, Holland EC
  • Organizer: The 3rd Quadrennial Meeting of the world Federation of Neuro-Oncology
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-05-14
• [Presentation] 悪性星細胞腫における浸潤能とp53変異の解析 (2009)
  • Author(s): 百田洋之, 他
  • Organizer: 第27回脳腫瘍病理学会、口演
  • Place of Presentation: アクロス福岡(福岡)
  • Year and Date: 2009-05-08
• [Presentation] 悪性星細胞腫における浸潤能とp53変異の解析 (2009)
  • Author(s): 百田洋之、成田善孝、宮北康二、四宮あや、渋井壮一郎
  • Organizer: 第27回脳腫瘍病理学会
  • Place of Presentation: アクロス福岡(福岡)
  • Year and Date: 2009-05-08
• [Presentation] Expression and prognostic significance of differentiation markers in primary CNS lymphoma (PCNSL) (2009)
  • Author(s): Momota H, Narita Y Maeshima AM, Miyakita Y, Shinomiya A, Maruyama T, Muragaki Y, Shibui S
  • Organizer: 45th American Society of Clinical Oncology (ASCO) Annual Meeting
  • Place of Presentation: Orange Country Convention Center (ORLANDO, FL, USA)
• [Book] がん診療レジデントマニュアル第5版「脳腫瘍」 (2010)
  • Author(s): 百田洋之, 他
  • Publisher: 医学書院
• [Book] がん診療レジデントマニュアル 第5版、「脳腫瘍」 (2010)
  • Author(s): 百田洋之
  • Publisher: 医学書院