| Project/Area Number |
21790400
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|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Experimental pathology
|
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| Research Institution | Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses |
|---|
Principal Investigator |
AKAZAWA Takashi Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses, 研究所, 研究員 (80359299)
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|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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|---|
| Keywords | 腫瘍 / 腫瘍免疫 / アジュバント / BCG-CWS / 創薬設計 / 自然免疫 / Toll-like receptor / がん免疫療法 / 樹状細胞 |
|---|
| Research Abstract |
It is essential to develop effective immunoadjuvants for tumor immunotherapy. We created new adjuvants based on the structure of mycoplasmal lipopeptide, which is a toll-like receptor (TLR) 2 ligand. Adjuvant engineering, substituting a functional motif for bacterial origin sequence of lipopeptide, is a novel drug design strategy. Here, we report the characterization of a new TLR2 ligand with complexation capability.
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