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Construction of genomic library from Malaria parasite using its artificial chromosome

Research Project

Project/Area Number 21790406
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Parasitology (including Sanitary zoology)
Research InstitutionMie University

Principal Investigator

IWANAGA Shiroh  Mie University, 大学院・医学系研究科, 准教授 (20314510)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsマラリア / 人工染色体 / マラリア原虫 / 遺伝子ライブラリー / テロメア
Research Abstract

To develop the system for the identification of drug resistance gene from parasite, we generate the high-coverage genomic library using the Plasmodium artificial chromosome (PAC) from drug resistance parasite. The targeted drug resistance gene could be identified by drug-screening from the PAC library which was made from the drug resistance parasite.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (17 results)

All 2011 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (7 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Journal Article] Functional Identification of the Plasmodium Centromere and Generation of a Plasmodium Artificial Chromosome.2010

    • Author(s)
      Iwanaga S, Khan SM., Kaneko I, Christodoulou Z, Newbold C, Yuda M, Janse CJ, Waters AP.
    • Journal Title

      Cell, Host & Microbe. 7, 3

      Pages: 245-245

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcription Factor AP2-Sp and its Target Genes in Malarial Sporozoites.2010

    • Author(s)
      Yuda M, Iwanaga S, Shigenobu S, Kato T, Kaneko I.
    • Journal Title

      Mol Microbiol. 75, 4

      Pages: 854-863

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional Identification of the Plasmodium Centromere and Generation of a Plasmodium Artificial Chromosome2010

    • Author(s)
      S.Iwanaga, M, yuda, et.al
    • Journal Title

      Cell, host & microbe

      Volume: Vol7(掲載確定)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a transcription factor in the mosquito-invasive stage of malaria parasites.2009

    • Author(s)
      Yuda M, Iwanaga S, Shigenobu S, Mair GR, Janse CJ, Waters AP, Kato T, Kaneko I.
    • Journal Title

      Mol Microbiol. 71, 6

      Pages: 1402-1414

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] マラリアワクチン開発の現況2009

    • Author(s)
      岩永史朗、鎮西靖男
    • Journal Title

      医学の歩み 231

      Pages: 3-3

    • Related Report
      2010 Final Research Report
  • [Journal Article] Identification of a transcription factor in the mosquito-invasive stage of malaria parasites2009

    • Author(s)
      M.Yuda, S.Iwanaga, et.al
    • Journal Title

      Mol Microbiol

      Volume: Vol71 Pages: 1402-1414

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcription Factor AP2-Sp and its Target Genes in Malarial Sporozoites2009

    • Author(s)
      M.Yuda, S.Iwanaga, et.al
    • Journal Title

      Mol Microbiol

      Volume: Vol75 Pages: 854-863

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Identification of Transcription factor of Malaria Sporozoite.2010

    • Author(s)
      S.Iwanaga, I.Kaneko, M.Yuda, Awaji
    • Organizer
      The 10th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Identification of Transcription factor of Malaria Sporozoite.2010

    • Author(s)
      Shiroh Iwanaga
    • Organizer
      The 10^<th> Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogo, Japan(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Identification of Transcription factor of Malaria Sporozoite.2009

    • Author(s)
      S.Iwanaga, I.Kaneko, M.Yuda ers
    • Organizer
      American Society of Tropical Medicine and Hygiene 58th Annual Meeting
    • Place of Presentation
      Washington, D.C.USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Functional Characterization of the plasmodium centromere and generation of a plasmodium artificial chromosome.2009

    • Author(s)
      S.Iwanaga, M.Yuda, I.Kaneko, C.J.Janse, A.P.Waters
    • Organizer
      American Society of Tropical Medicine and Hygiene 58th Annual Meeting
    • Place of Presentation
      Washington, D.C.USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Generation of a Plasmodium Artificial Chromosome2009

    • Author(s)
      S.Iwanaga, Awaji
    • Organizer
      The 9th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] Functional Characterization of the plasmodium centromere and generation of a plasmodium artificial chromosome2009

    • Author(s)
      S.Iwanaga
    • Organizer
      American Society of Tropical Medicine and Hygiene 58^<th> Annual Meeting
    • Place of Presentation
      Washington, D.C.USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Generation of a Plasmodium Artificial Chromosome2009

    • Author(s)
      S.Iwanaga
    • Organizer
      The 9^<th> Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Japan
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] マラリア原虫人工染色体を用いた薬剤耐性遺伝子の迅速同定法および組換えマラリア原虫作製法2011

    • Inventor(s)
      岩永史朗・油田正夫・金子伊澄
    • Industrial Property Rights Holder
      国立大学三重大学
    • Filing Date
      2011-03-26
    • Related Report
      2010 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] マラリア原虫人工染色体を用いた薬剤耐性遺伝子の迅速同定法および組換えマラリア原虫作製法2011

    • Inventor(s)
      岩永史朗・金子伊澄・油田正夫
    • Industrial Property Rights Holder
      三重大学
    • Filing Date
      2011-03-26
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] マラリア原虫人工染色体を用いた薬剤耐性遺伝子の迅速同定法2010

    • Inventor(s)
      岩永史朗・油田正夫
    • Industrial Property Rights Holder
      国立大学三重大学
    • Industrial Property Number
      2010-071688
    • Filing Date
      2010-03-26
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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