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Mechanism of mycobacterial growth using host hyaluronan and novel antitubercular drug development targeting mycobacterial hyaluronidase.

Research Project

Project/Area Number 21790426
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Bacteriology (including Mycology)
Research InstitutionOsaka City University

Principal Investigator

NIKI Mamiko  Osaka City University, 大学院・医学研究科, 助教 (20438229)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords結核ビアルロン酸抗結核薬 / 結核 / ヒアルロン酸 / 抗結核薬
Research Abstract

We found that mycobacteria can grow utilizing hyaluronan (HA) as a carbon source. The expression of HA synthase in the was increased after infection of M. tuberculosis. We showed HAase inhibitor suppressed growth of mycobacteria in vivo.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (16 results)

All 2011 2010 2009

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (2 results)

  • [Journal Article] Effects of non-iron metalloporphyrins on growth and gene expression of Porphyromonas gingivalis.2011

    • Author(s)
      Yukitake H, Naito M, Sato K, Shoji M, Ohara N, Yoshimura M, Sakai E, Nakayama K.
    • Journal Title

      Microb Immun 55(3)

      Pages: 141-153

    • NAID

      10031121453

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in salivary antimicrobial peptides, immunoglobulin A and cortisol after prolonged strenuous exercise.2011

    • Author(s)
      Usui T, Yoshikawa T, Orita K, Ueda SY, Katsura Y, Fujimoto S, Yoshimura M.
    • Journal Title

      Eur J Appl Physiol

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of non-iron metalloporphyrins on growth and gene expression of Porphyromonas gingivalis.2011

    • Author(s)
      Yukitake, H., M.Yoshimura
    • Journal Title

      Microb.Immunol.

      Volume: 55 Pages: 141-153

    • NAID

      10031121453

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tetratricopeptide repeat protein-associated proteins contribute to the virulence of Porphyromonas gingivalis.2010

    • Author(s)
      Kondo Y, Ohara N, Sato K, Yoshimura M, Yukitake H, Naito M, Fujiwara T, Nakayama K.
    • Journal Title

      Infect Immun. 78(6)

      Pages: 2846-2856

    • NAID

      120006984317

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in salivary antimicrobial peptides, immunoglobulin A and cortisol after prolonged strenuous exercise.2010

    • Author(s)
      Usui, T., M.Yoshimura, et al.
    • Journal Title

      Eur.J.Appl.Physiol.

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tetratricopeptide repeat protein-associated proteins contribute to the virulence of Porphyromonas gingivalis.2010

    • Author(s)
      Kondo, Y., M.Yoshimura, et al.
    • Journal Title

      Infect.Immun.

      Volume: 78 Pages: 2846-2856

    • NAID

      120006984317

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mycobacteria exploit host hyaluronan for efficient extracellular replication.2009

    • Author(s)
      Hirayama Y, Yoshimura M, Ozeki Y, Sugawara I, Udagawa T, Mizuno S, Itano N, Kimata K, Tamaru A, Ogura H, Kobayashi K, Matsumoto S.
    • Journal Title

      PLos Pathog. 5(10)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hydrogen sulfide production from cysteine and homocysteine by periodontal and oral bacteria.2009

    • Author(s)
      Yoshida A, Yoshimura M, Ohara N, Yoshimura S, Nagashima S, Takehara T, Nakayama K.
    • Journal Title

      J.Periodontol. 80(11)

      Pages: 1845-1851

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mycobacterium avium complex organisms predominantly colonize in the bathtub inlets of patients'bathrooms.2009

    • Author(s)
      Nishiuchi Y, Tamura A, Kitada S, Taguri T, Matsumoto S. Tateishi Y, Yoshimura M, Ozeki Y, Matsumura N, Ogura H, Maekura R.
    • Journal Title

      Jpn J Infect Dis. 62(3)

      Pages: 182-186

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Virulence of Mycobacterium avium complex strains isolated from immunocompetent patients.2009

    • Author(s)
      Tateishi Y, Hirayama Y, Ozeki Y, Nishiuchi Y, Yoshimura M, Kang J, Shibata A, Hirata K, Kitada S, Maekura R, Ogura H, Kobayashi K, Matsumoto S.
    • Journal Title

      Microb Pathog. 46(1)

      Pages: 6-12

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mycobacteria exploit host hyaluronan for efficient extracellular replication2009

    • Author(s)
      Hirayama, Y., M.Yoshimura, et al.
    • Journal Title

      Plos Pathog 5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydrogen sulfide production from cysteine and homocysteine by periodontal and oral bacteria2009

    • Author(s)
      Yoshida, A., M.Yoshimura, et al.
    • Journal Title

      J Periodontol 80

      Pages: 1845-51

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Virulence of Mycobacterium avium complex strains isolated from immunocompetent patients.2009

    • Author(s)
      Tateishi, Y., M.Yoshimura, et al.
    • Journal Title

      Microb Pathog 46

      Pages: 6-12

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mycobacterium avium complex organisms predominantly colonize in the bathtub inlets of patients' bathrooms.2009

    • Author(s)
      Nishiuchi, Y., M.Yoshimura, et al.
    • Journal Title

      Jpn J Infect Dis 62

      Pages: 182-6

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 休眠時における抗酸菌の遺伝子発現解析2009

    • Author(s)
      吉村満美子
    • Organizer
      第62回日本細菌学会関西支部総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 抗酸菌の休眠誘導と遺伝子発現解析2009

    • Author(s)
      吉村満美子
    • Organizer
      第7回感染症沖縄フォーラム
    • Place of Presentation
      沖縄
    • Year and Date
      2009-02-11
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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