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Screening for a new meningococcal pathogenic factor by STM

Research Project

Project/Area Number 21790435
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Bacteriology (including Mycology)
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

TAKAHASHI Hideyuki  国立感染症研究所, 細菌第一部, 主任研究官 (60321866)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords感染症 / 微生物 / 髄膜炎菌 / Neisseria meningitidis / 病原因子 / Signature Tag Mutagenesis / トランスポゾン変異 / 変異株 / signature tag mutagenesis
Research Abstract

I constructed a transposon-inserted meningococcal mutant library by STM and screened adhesion or invasion-defective mutants to human brain microvasocular endothelial cells. By the 5th steps of screening, 31 mutants were finally selected.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2012 2011 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (6 results) Book (3 results)

  • [Journal Article] Meningococcal internalization into human endothelial and epithelial cell-s is triggered by the influx of extracellular L-glutamate via GltT L-glutamate ABC transporter in Neisseria meningitidis2011

    • Author(s)
      H. Takahashi, K. S. Kim and H. Watanabe
    • Journal Title

      Infection and Immunity

      Volume: 79 Issue: 1 Pages: 380-392

    • DOI

      10.1128/iai.00497-10

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Meningococcal internalization into human endothelial and epithelial cells is triggered by the influx of extracellular L-glutamate via GltT L-glutamate ABC transporter in Neisseria meningitides2011

    • Author(s)
      H.Takahashi, K.S.Kim, H.Watanabe
    • Journal Title

      Infection and Immunity

      Volume: 79 Pages: 380-392

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunomoduatory effects of Yerisinia pestis Lipopolysaccharides on human Macrophages2010

    • Author(s)
      M. Matsuura, H. Takahashi, H. Watanabe and K. Kawahara
    • Journal Title

      Clinical and Vaccine Immunology

      Volume: 17 Issue: 1 Pages: 49-55

    • DOI

      10.1128/cvi.00336-09

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunomoduatory effects of Yerisinia pestis Lipopolysaccharideson human Macrophages2010

    • Author(s)
      M. Matsuura, H. Takahashi, H. Watanabe, K. Kawahara
    • Journal Title

      Clinical and Vaccine Immunology 17

      Pages: 49-55

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 髄膜炎菌の線毛のマイナータンパクPilVの宿主細胞感染における遺伝学的及び物理化学的手法を用いた機能解析2012

    • Author(s)
      高橋英之、大西真
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 髄膜炎菌の線毛のマイナータンパクPilVの宿主細胞感染における遺伝学的及び物理化学的手法を用いた機能解析2012

    • Author(s)
      高橋英之、大西真
    • Organizer
      日本細菌学会総会
    • Place of Presentation
      長崎市
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 国内分離された髄膜炎菌株の分子役学的解析とそれらを用いたNeisseria meningitidisの病原因子の解析2009

    • Author(s)
      高橋英之
    • Organizer
      第92回細菌学会関東支部会シンポジウム
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2009-11-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 国内分離された髄膜炎菌株の分子役学的解析とそれらを用いたNeisseria menlngitidisの病原因子の解析2009

    • Author(s)
      高橋英之
    • Organizer
      第92回細菌学会関東支部会シンポジウム
    • Place of Presentation
      東京都文京区東京医科歯科大学5号館講堂
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細菌感染時の髄膜炎菌の一過的なグルタミン酸の取込みが宿主細胞への侵入に必須である2009

    • Author(s)
      高橋英之、渡邉治雄
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      神奈川県横浜市西区パシフィコ横浜
    • Year and Date
      2009-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細菌感染時の髄膜炎菌の一過的なグルタミン酸の取込みが宿主細胞への侵入に必須である2009

    • Author(s)
      高橋英之、渡邉治雄
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-24
    • Related Report
      2011 Final Research Report
  • [Book] 感染症辞典2012

    • Author(s)
      川端寛樹、高橋英之
    • Publisher
      オーム社
    • Related Report
      2011 Final Research Report
  • [Book] 感染症辞典3-27ペスト2012

    • Author(s)
      川端寛樹、高橋英之
    • Total Pages
      5
    • Publisher
      オーム社
    • Related Report
      2011 Annual Research Report
  • [Book] 病原菌の今日的意味14.髄膜炎菌2011

    • Author(s)
      高橋英之、大西真
    • Publisher
      医薬ジャーナル社
    • Related Report
      2011 Annual Research Report 2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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