Study on the mechanism of hepatitis C virus infection-induced apoptosis
| Project/Area Number |
21790446
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | Kobe University |
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Principal Investigator |
DENG LIN Kobe University, 大学院・医学研究科, グローバルCOE研究員 (40437497)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | C型肝炎ウイルス / アポトーシス / ミトコンドリア / Bax / JNK |
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| Research Abstract |
In this study, by using the J6/JFH1 strain of HCV and Huh7.5 cells, I demonstrated that HCV-induced ROS production triggers JNK activation, which leads to Bax activation and apoptosis. I also found that HCV core plays a role in HCV-induced apoptosis.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Secondary structure of the amino-terminal region of HCV NS3 and virological response to pegylated interferon plus ribavirin therapy for chronic hepatitis C.2010
Author(s)
Sanjo M, Saito T, Ishii R, Nishise Y, Haga H, Okumoto K, Ito J, Watanabe H, Saito K, Togashi H, Fukuda K, Imai Y, El-Shamy A, Deng L, Shoji I, Hotta H, Kawata S.
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Journal Title
J.Med.Virol. 82(8)
Pages: 1364-1370
Related Report
Peer Reviewed
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