Tne regulation mechanism of pre-B cell receptor expression and pre-B acute lymphoblastic lymphomagenesis

• Project/Area Number: 21790461
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KAWANO Youhei Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 (20401383)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: プレB細胞 / pre-BCR / リソソーム / BCR

Research Abstract

Pre-BCR is a constitutively active receptor, transienly expressed on only pre-B cells, and its abberant expression cause pre-B acute lymphoblastic lymphoma. We study the regulation mechanism of the pre-BCR expression, and identified a molecule localized in lysosome that is involved in the degradation of pre-BCR.

Research Products

• [Journal Article] Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. (2010)
  • Author(s): Wada T, Ishiwata K, Koseki H, Ishikura T, Ugajin T, Ohnuma N, Obata K, Ishikawa R, Yoshikawa S, Mukai K, Kawano Y, Minegishi Y, Yokozeki H, Watanabe N, Karasuyama H.
  • Journal Title: J Clin Invest. 120(8) Pages: 2867-2875
• [Journal Article] IgG-mediated systemic anaphylaxis toprotein antigen can be induced evenunder conditions of limited amounts of antibody and antigen. (2010)
  • Author(s): Ishikawa R, Tsujimura Y, Obata K, Kawano Y, Minegishi Y, Karasuyama H.
  • Journal Title: Biochem Biophys Res Commun. 402(4) Pages: 742-746
• [Journal Article] Basophils preferentially expressmouse Mast Cell Protease 11 among the mast cell tryptase family incontrast to mast cells. (2009)
  • Author(s): Ugajin T, Kojima T, Mukai K, ObataK, Kawano Y, Minegishi Y, Eishi Y,Yokozeki H, Karasuyama H.
  • Journal Title: J Leukoc Biol. 86(6) Pages: 1417-1425
• [Presentation] A novel mechanism for the autonomous termination of pre-Bcell receptor expression through BLNK-mediated induction of LAPTM5. (2010)
  • Author(s): Kawano Y., Ouchida R, O-Wang Jiyang, Yoshikawa S, Yamamoto M., Kitamura D., Karasuyama H.
  • Organizer: International Congress of Immunology 2010
  • Place of Presentation: Kobe
  • Year and Date: 2010-08-24
• [Presentation] A novel mechanism for the autonomous termination of pre-B cell receptor expression through BLNK-mediated induction of LAPTM5 (2010)
  • Author(s): 河野洋平
  • Organizer: 国際免疫学会2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-24
• [Presentation] A novel mechanism for the autonomous termination of pre-B cell receptor expression through BLNK-mediated induction of LAPTM5 (2009)
  • Author(s): 河野洋平
  • Organizer: 日本免疫学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-04
• [Presentation] A novel mechanism for the autonomous termination of pre-Bcell receptor expression through BLNK-mediated induction of LAPTM5. (2009)
  • Author(s): Kawano Y., Ouchida R, O-Wang Jiyang, Yoshikawa S, Yamamoto M., Kitamura D., Karasuyama H.
  • Organizer: The 39th JSI annual meeting.
  • Place of Presentation: Osaka